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Article | Open Access

Study on synergistic effect of new functionalized Ag nanoparticles for intracellular drug uptake in cancer cells

Yanyan Zhou, Xuemei Wang( )
State Key Lab of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, Nanjing 210096, P. R. China
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Abstract

In this study, we have explored the possibility of the application of the functionalized silver nanoparticles (Ag NPs) as drug carriers allied with anticancer drug daunorubicin (DNR) for efficient cancer chemotherapy. The results demonstrate that Ag NPs can enhance the intracellular drug DNR accumulation concentration in the leukemia K562 cells and thereby increase the killing effect on the leukemia K562 cells.

Keywords

DNR-Ag NPs nanocompositesleukemia K562 cellsDrug delivery system

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Nano Biomedicine and Engineering
Volume 2 Issue 4,
December 2010
Pages 208-213
DOI: 10.5101/nbe.v2i4.p208-213

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Cite this article:
Zhou Y, Wang X. Study on synergistic effect of new functionalized Ag nanoparticles for intracellular drug uptake in cancer cells. Nano Biomedicine and Engineering, 2010, 2(4): 208-213. https://doi.org/10.5101/nbe.v2i4.p208-213

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Received: 15 November 2010
Accepted: 06 December 2010
Published: 15 December 2010
© 2010 Yanyan Zhou, et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.