Journal Home > Volume 14 , Issue 1
Nano Biomedicine and Engineering 2022, 14(1): 90-106 https://doi.org/10.5101/nbe.v14i1.p90-106
Review | Open Access | Issue | Published: 12 May 2022

Nanoparticles as Carriers in Medical Applications: A Review Focusing on the Preparation and Use of Nanoparticles in Tissue Regeneration

Show Author's Information Andres Arias-Arana1,  Luis Palomino-Marcelo1,2,  Miguel Gakiya-Teruya1,  Pamela Areche-Vargas1,  Anand Ramamurthi3,  Juan Carlos Rodriguez-Reyes1,2( )
Nanoscience and applications laboratory-NASCA, Department ofChemical Engineering, Universidad de Ingenieria y Tecnologia-UTEC, Jr. Medrano Silva165, Barranco, Lima 04, Peru
Bioengineering Research Center, Universidad de Ingenieria y Tecnologia-UTEC, Jr. Medrano Silva 165, Barranco, Lima 04, Peru
Department of Bioengineering, Lehigh University, Bethlehem, Pennsylvania 18015, USA
Keywords:
Nanoparticles, Nanomedicine, Peptides, Tissue regeneration
Cite this article:
Arias-Arana A, Palomino-Marcelo L, Gakiya-Teruya M, et al. Nanoparticles as Carriers in Medical Applications: A Review Focusing on the Preparation and Use of Nanoparticles in Tissue Regeneration. Nano Biomedicine and Engineering, 2022, 14(1): 90-106. https://doi.org/10.5101/nbe.v14i1.p90-106
Download citation
EndNote(RIS)
BibTeX

820

Views

80

Downloads

Citations

2

Crossref

N/A

WoS

1

Scopus

N/A

CSCD

Abstract Full text About this article

Nanotechnology and its applications to medicine, known as nanomedicine, involve a wide use of nanomaterials to stimulate and guide the regenerative properties of cells. In particular, tissue regeneration can be promoted by enabling a controlled release of therapeutic agents, which can be done using nanoparticles. In this review article, the fundamentals of tissue regeneration are discussed, focusing on epithelial tissue, to demonstrate the importance of delivering therapeutic agents in an efficient, sustained and localized manner. Then, the methods for synthesizing metallic and polymeric nanoparticles are described. While polymeric nanoparticles can be loaded with an agent during synthesis, metallic nanoparticles must first be synthesized to later interact with therapeutic agents. This interaction can be fine-tuned by functionalizing metallic nanoparticles with organic molecules, which results in a more controlled attachment.This review highlights the importance of choosing the appropriate method of synthesis and functionalization, which must be designed considering both the type of tissue to regenerate and the nature of the agent to be transported.


menu
Abstract
Full text
Outline
About this article

Nanoparticles as Carriers in Medical Applications: A Review Focusing on the Preparation and Use of Nanoparticles in Tissue Regeneration

Show Author's information Andres Arias-Arana1, Luis Palomino-Marcelo1,2, Miguel Gakiya-Teruya1, Pamela Areche-Vargas1, Anand Ramamurthi3, Juan Carlos Rodriguez-Reyes1,2( )
Nanoscience and applications laboratory-NASCA, Department ofChemical Engineering, Universidad de Ingenieria y Tecnologia-UTEC, Jr. Medrano Silva165, Barranco, Lima 04, Peru
Bioengineering Research Center, Universidad de Ingenieria y Tecnologia-UTEC, Jr. Medrano Silva 165, Barranco, Lima 04, Peru
Department of Bioengineering, Lehigh University, Bethlehem, Pennsylvania 18015, USA

Abstract

Nanotechnology and its applications to medicine, known as nanomedicine, involve a wide use of nanomaterials to stimulate and guide the regenerative properties of cells. In particular, tissue regeneration can be promoted by enabling a controlled release of therapeutic agents, which can be done using nanoparticles. In this review article, the fundamentals of tissue regeneration are discussed, focusing on epithelial tissue, to demonstrate the importance of delivering therapeutic agents in an efficient, sustained and localized manner. Then, the methods for synthesizing metallic and polymeric nanoparticles are described. While polymeric nanoparticles can be loaded with an agent during synthesis, metallic nanoparticles must first be synthesized to later interact with therapeutic agents. This interaction can be fine-tuned by functionalizing metallic nanoparticles with organic molecules, which results in a more controlled attachment.This review highlights the importance of choosing the appropriate method of synthesis and functionalization, which must be designed considering both the type of tissue to regenerate and the nature of the agent to be transported.

Keywords: Nanoparticles, Nanomedicine, Peptides, Tissue regeneration

References(118)

[1]

Sahoo S.K., Parveen S., Panda J.J., The present and future of nanotechnology in human health care. Nanomedicine: Nanotechnology, Biology, and Medicine, 2007, 3(1): 20-31.
DOI Google Scholar
[2]

Kaur M., Singh G., Khanna K., et al., Nanotechnology: A Review. Second National Conference on Advances in manufacturing Systems. 2015: 1-7.
Google Scholar
[3]

Haider A., Kang I.K., Preparation of silver nanoparticles and their industrial and biomedical applications: A comprehensive review. Advances in Materials Science and Engineering, 2015, 2015.
DOI Google Scholar
[4]

Rajasundari K., Ilamurugu K., Nanotechnology and Its Applications in Medical Diagnosis. J. Basic. Appl. Chem, 2011, 1(2): 26-32.
Google Scholar
[5]
Altintas Z., Applications of Magnetic Nanomaterials in Biosensors and Diagnostics [Internet]. Biosensors and Nanotechnology: Applications in Health Care Diagnostics. John Wiley & Sons, Inc., 2017: 277-296.
DOI
[6]

Liu X.L., Chen S., Zhang H., et al., Magnetic Nanomaterials for Advanced Regenerative Medicine: The Promise and Challenges. Advanced Materials, 2019, 31(45): 1-13.
DOI Google Scholar
[7]
Ivanova N., Gugleva V., Dobreva M., et al., Silver Nanoparticles as Multi-Functional Drug Delivery Systems [Internet]. Nanomedicines. IntechOpen, 2019: 71-92.
DOI
[8]
Yang Y., Chawla A., Zhang J., et al., Applications of Nanotechnology for Regenerative Medicine; Healing Tissues at the Nanoscale [Internet]. Principles of Regenerative Medicine. Elsevier Inc., 2019: 485-504.
DOI
[9]

Bellu E., Medici S., Coradduzza D., et al., Nanomaterials in skin regeneration and rejuvenation. International Journal of Molecular Sciences, 2021, 22(13).
DOI Google Scholar
[10]

Eftekhari A., Dizaj S.M., Sharifi S., et al., The use of nanomaterials in tissue engineering for cartilage regeneration; current approaches and future perspectives. International Journal of Molecular Sciences, 2020, 21(2).
DOI Google Scholar
[11]

Funda G., Taschieri S., Bruno G.A., et al., Nanotechnology Scaffolds for Alveolar Bone Regeneration. Materials, 2020, 13(201).
DOI Google Scholar
[12]
Murthy S.K., Nanoparticles in modern medicine: state of the art and future challenges. International journal of nanomedicine, 2007, 2(2): 129-141. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17722542%0Ahttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC2673971.
[13]

Salata O.V., Applications of nanoparticles in biology and medicine. Journal of Nanobiotechnology, 2004, 6(3): 1-6.
DOI Google Scholar
[14]

Cui L., Liang J., Liu H., et al., Nanomaterials for Angiogenesis in Skin Tissue Engineering. Tissue Engineering-Part B: Reviews, 2020, 26(3): 203-216.
DOI Google Scholar
[15]
Gong T., Xie J., Liao J., et al., Nanomaterials and bone regeneration. Bone Research, 2015, 3(July).
DOI
[16]
Pei B., Wang W., Dunne N., et al., Applications of carbon nanotubes in bone tissue regeneration and engineering: Superiority, concerns, current advancements, and prospects. 2019:
DOI
[17]

Guazzo R., Gardin C., Bellin G., et al., Graphene-based nanomaterials for tissue engineering in the dental field. Nanomaterials, 2018, 8(5): 1-31.
DOI Google Scholar
[18]

Lauritano D., Limongelli L., Moreo G., et al., Nanomaterials for periodontal tissue engineering: Chitosan-based scaffolds. A systematic review. Nanomaterials, 2020, 10(4): 1-16.
DOI Google Scholar
[19]
Watson T., Soft Tissue Wound Healing Review[Internet]. 2004, Available from: http://www.electrotherapy.org/modality/soft-tissue-repair-and-healing-review#Overview.
[20]

Wagner S., Coerper S., Fricke J., et al., Comparison of inflammatory and systemic sources of growth factors in acute and chronic human wounds. Wound Repair and Regeneration, 2003, 11(4): 253-260.
DOI Google Scholar
[21]

Cabrera C., Carriquiry G., Pierinelli C., et al., The role of biologically active peptides in tissue repair using umbilical cord mesenchymal stem cells. Annals of the New York Academy of Sciences, 2012, 1270(1): 93-97.
DOI Google Scholar
[22]

Papini R., ABC of burns: Management of burn injuries of various depths. British Medical Journal, 2004, 329(7458): 158-160.
DOI Google Scholar
[23]

Craik D.J., Fairlie D.P., Liras S., et al., The Future of Peptide-based Drugs. Chemical Biology and Drug Design, 2013, 81(1): 136-147.
DOI Google Scholar
[24]

Bruno B.J., Miller G.D., Lim C.S., Basics and recent advances in peptide and protein drug delivery While. Therapeutic Delivery, 2013, 4(11): 1443-1467.
DOI Google Scholar
[25]

Taneja K., Pareek A., Verma P., et al., Nanocomposite: An emerging tool for bone tissue transplantation and drug delivery. Indian Journal of Transplantation, 2012, 6(3): 88-96.
DOI Google Scholar
[26]

Costerton J.W., Stewart P.S., Greenberg E.P., Bacterial biofilms: A common cause of persistent infections. Science, 1999, 284(5418): 1318-1322.
DOI Google Scholar
[27]

G. Efremov R., O. Chugunov A., V. Pyrkov T., et al., Molecular Lipophilicity in Protein Modeling and Drug Design. Frontiers in Medicinal Chemistry, 2012, 14: 249-290.
DOI Google Scholar
[28]

Sivaraman B., Bashur C.A., Ramamurthi A., Advances in biomimetic regeneration of elastic matrix structures. Drug Delivery and Translational Research, 2012, 2(5): 323-350.
DOI Google Scholar
[29]

Gakiya-Teruya M., Palomino-Marcelo L., Pierce S., et al., Enhanced antimicrobial activity of silver nanoparticles conjugated with synthetic peptide by click chemistry. Journal of Nanoparticle Research, 2020, 22(4).
DOI Google Scholar
[30]

Hayley B., Frenkel E., Nanoparticles for drug delivery in cancer treatment. Urol. Oncol. , 2008, 26: 57-64.
DOI Google Scholar
[31]

Karin M., Clevers H., Reparative inflammation takes charge of tissue regeneration. Nature, 2016, 529(7586): 307-315.
DOI Google Scholar
[32]

Chu C., Deng J., Liu L., et al., Nanoparticles combined with growth factors: Recent progress and applications. RSC Advances, 2016, 6(93): 90856-90872.
DOI Google Scholar
[33]

Krafts K.P., Tissue repair: The hidden drama. Organogenesis, 2010, 6(4): 225-233.
DOI Google Scholar
[34]

Schmidt C., Bladt F., Goedecke S., et al., Scatter factor/hepatocyte growth factor is essential for liver development. Nature. 1995, 373(6516): 699-702.
DOI Google Scholar
[35]

Elsabahy M., Wooley K.L., Cytokines as biomarkers of nanoparticle immunotoxicity. Chemical Society Reviews, 2013, 42(12): 5552-5576.
DOI Google Scholar
[36]

DeCarbo W.T., Special Segment: Soft Tissue Matrices — Apligraf Bilayered Skin Substitute to Augment Healing of Chronic Wounds in Diabetic Patients. Foot & Ankle Specialist, 2009, 2(6): 299-302.
DOI Google Scholar
[37]

Gonçalves A., Machado R., Gomes A.C., et al., Nanotechnology solutions for controlled cytokine delivery: An applied perspective. Applied Sciences (Switzerland), 2020, 10(20): 1-14.
DOI Google Scholar
[38]

Merrifield R.B., Solid Phase Synthesis (Nobel Lecture). Angewandte Chemie International Edition in English, 1985, 24(10): 799-810.
DOI Google Scholar
[39]

Kaiser E., Colescott R., Bossinger C., et al., Color Test for Detection of Free Terminal Amino Groups in the Solid-Phase Synthesis of Peptides. Journal of Analytical Biochemistry, 1970, 34(2): 595-598.
DOI Google Scholar
[40]

Singh R., Nalwa H.S., Medical applications of nanoparticles in biological imaging, cell labeling, antimicrobial agents, and anticancer nanodrugs. Journal of Biomedical Nanotechnology, 2011, 7(4): 489-503.
DOI Google Scholar
[41]

Stensberg M.C., Wei Q., McLamore E.S., et al., Toxicological studies on silver nanoparticles: Challenges and opportunities in assessment, monitoring and imaging. Nanomedicine, 2011, 6(5): 879-898.
DOI Google Scholar
[42]

Parveen S., Misra R., Sahoo S.K., Nanoparticles: a boon to drug delivery, therapeutics, diagnostics and imaging. Nanomedicine Nanotechnology, Biol. Med. , 2012, 8: 147-166.
DOI Google Scholar
[43]

Biju V., Chemical modifications and bioconjugate reactions of nanomaterials for sensing, imaging, drug delivery and therapy. Chemical Society Reviews, 2014, 43(3): 744-764.
DOI Google Scholar
[44]

Gómez-Gaete C., Nanopartículas Poliméricas: Tecnología y Aplicaciones Farmacéuticas. Revista farmacologica de Chile, 2014, 7(2): 7-16.
Google Scholar
[45]

Jiang X., Lin H., Jiang D., et al., Co-delivery of VEGF and bFGF via a PLGA nanoparticle-modified BAM for effective contracture inhibition of regenerated bladder tissue in rabbits. Nature Publishing Group, 2016, (February): 1-12.
DOI Google Scholar
[46]

Wei P., Xu Y., Gu Y., et al., IGF-1-releasing PLGA nanoparticles modified 3D printed PCL scaffolds for cartilage tissue engineering. Drug Delivery, 2020, 27(1): 1106-1114.
DOI Google Scholar
[47]

Vial S., Reis R.L., Oliveira J.M., Recent advances using gold nanoparticles as a promising multimodal tool for tissue engineering and regenerative medicine. Current Opinion in Solid State and Materials Science, 2017, 21(2): 92-112.
DOI Google Scholar
[48]

Tkachenko A.G., Xie H., Liu Y., et al., Cellular trajectories of peptide-modified gold particle complexes: Comparison of nuclear localization signals and peptide transduction domains. Bioconjugate Chemistry, 2004, 15: 482-490.
DOI Google Scholar
[49]

Chaudhury K., Kumar V., Kandasamy J., et al., Regenerative nanomedicine: Current perspectives and future directions. International Journal of Nanomedicine, 2014, 9(1): 4153-4167.
DOI Google Scholar
[50]

Agnihotri S., Mukherji S., Mukherji S., Size-controlled silver nanoparticles synthesized over the range 5-100 nm using the same protocol and their antibacterial efficacy. RSC Advances, 2014, 4(8): 3974-3983.
DOI Google Scholar
[51]

Xiu Z.M., Zhang Q.B., Puppala H.L., et al., Negligible particle-specific antibacterial activity of silver nanoparticles. Nano Letters, 2012, 12(8): 4271-4275.
DOI Google Scholar
[52]

Wang Y., Wan J., Miron R.J., et al., Antibacterial properties and mechanisms of gold-silver nanocages. Nanoscale, 2016, 8(21): 11143-11152.
DOI Google Scholar
[53]

Lara H.H., Ayala-Núñez N.V., del Turrent L.C.I., et al., Bactericidal effect of silver nanoparticles against multidrug-resistant bacteria. World Journal of Microbiology and Biotechnology, 2010, 26(4): 615-621.
DOI Google Scholar
[54]

Shamaila S., Zafar N., Riaz S., et al., Gold nanoparticles: An efficient antimicrobial agent against enteric bacterial human pathogen. Nanomaterials, 2016, 6(4): 1-10.
DOI Google Scholar
[55]

Zhou Y., Kong Y., Kundu S., et al., Antibacterial activities of gold and silver nanoparticles against Escherichia coli and bacillus Calmette-Guérin. Journal of Nanobiotechnology, 2012, 10: 1-9.
DOI Google Scholar
[56]

Nagaonkar D., Rai M., Sequentially reduced biogenic silver-gold nanoparticles with enhanced antimicrobial potential over silver and gold monometallic nanoparticles. Advanced Materials Letters, 2015, 6(4): 334-341.
DOI Google Scholar
[57]

Auffan M., Rose J., Bottero J.Y., et al., Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective. Nature Nanotechnology, 2009, 4(10): 634-641.
DOI Google Scholar
[58]

Das B., Dash S.K., Mandal D., et al., Green synthesized silver nanoparticles destroy multidrug resistant bacteria via reactive oxygen species mediated membrane damage. Arabian Journal of Chemistry, 2017, 10(6): 862-876.
DOI Google Scholar
[59]

Hamdan S., Pastar I., Drakulich S., et al., Nanotechnology-Driven Therapeutic Interventions in Wound Healing: Potential Uses and Applications. ACS Central Science, 2017, 3(3): 163-175.
DOI Google Scholar
[60]

Lin Y., Watson K.A., Fallbach M.J., et al., Rapid, solventless, bulk preparation of metal nanoparticle-decorated carbon nanotubes. ACS Nano, 2009, 3(4): 871-884.
DOI Google Scholar
[61]

Sakamoto M., Fujistuka M., Majima T., Light as a construction tool of metal nanoparticles: Synthesis and mechanism. Journal of Photochemistry and Photobiology C: Photochemistry Reviews, 2009, 10(1): 33-56.
DOI Google Scholar
[62]

Christensen S.T., Feng H., Libera J.L., et al., Supported Ru-Pt bimetallic nanoparticle catalysts prepared by atomic layer deposition. Nano Letters, 2010, 10(8): 3047-3051.
DOI Google Scholar
[63]

Tri Handoko C., Huda A., Gulo F., Synthesis Pathway and Powerful Antimicrobial Properties of Silver Nanoparticle: A Critical Review. Asian Journal of Scientific Research, 2019, 12(1): 1-17.
DOI Google Scholar
[64]

Singh P., Kim Y.J., Zhang D., et al., Biological Synthesis of Nanoparticles from Plants and Microorganisms. Trends in Biotechnology, 2016, 34(7): 588-599.
DOI Google Scholar
[65]

Evanoff D.D., Chumanov G., Synthesis and optical properties of silver nanoparticles and arrays. Chem Phys Chem, 2005, 6(7): 1221-1231.
DOI Google Scholar
[66]

Brown S.D., Nativo P., Smith J.A., et al., Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin. Journal of the American Chemical Society, 2010, 132(13): 4678-4684.
DOI Google Scholar
[67]

Polte J., Ahner T.T., Delissen F., et al., Mechanism of gold nanoparticle formation in the classical citrate synthesis method derived from coupled in situ XANES and SAXS evaluation. Journal of American Chemical Society, 2010, 132(9): 1296-1301.
DOI Google Scholar
[68]

Alexandridis P., Gold Nanoparticle Synthesis, Morphology Control, and Stabilization Facilitated by Functional Polymers. Chemical Engineering and Technology, 2011, 34(1): 15-28.
DOI Google Scholar
[69]

Han J., Li L., Guo R., Novel approach to controllable synthesis of gold nanoparticles supported on polyaniline nanofibers. Macromolecules, 2010, 43(24): 10636-10644.
DOI Google Scholar
[70]

Lu X., Rycenga M., Skrabalak S.E., et al., Chemical Synthesis of Novel Plasmonic Nanoparticles. Annual Review of Physical Chemistry, 2009, 60(1): 167-192.
DOI Google Scholar
[71]
Egorova E.M., Kubatiev A.A., Schvets V.I., Biological Effects of Metal Nanoparticles [Internet]. 1st ed. Springer International Publishing, 2016.
DOI
[72]

Gakiya-Teruya M., Palomino-Marcelo L., Rodriguez-Reyes J.C.F., Synthesis of highly concentrated suspensions of silver nanoparticles by two versions of the chemical reduction method. Methods and Protocols, 2019, 2(1): 1-5.
DOI Google Scholar
[73]

Mehanna M.M., Mohyeldin S.M., Elgindy N.A., Respirable nanocarriers as a promising strategy for antitubercular drug delivery. Journal of Controlled Release, 2014, 187: 183-197.
DOI Google Scholar
[74]

Liu T.Y., Hu S.H., Liu D.M., et al., Biomedical nanoparticle carriers with combined thermal and magnetic responses. Nano Today, 2009, 4(1): 52-65.
DOI Google Scholar
[75]

Sivaraman B., Sylvester A., Ramamurthi A., Fibrinolytic PLGA nanoparticles for slow clot lysis within abdominal aortic aneurysms attenuate proteolytic loss of vascular elastic matrix. Materials Science and Engineering C, 2016, 59: 145-156.
DOI Google Scholar
[76]

Chávez J.L., Lyon W., Kelley-Loughnane N., et al., Theophylline detection using an aptamer and DNA-gold nanoparticle conjugates. Biosensors and Bioelectronics, 2010, 26(1): 23-28.
DOI Google Scholar
[77]

Chávez J.L., MacCuspie R.I., Stone M.O., et al., Colorimetric detection with aptamer-gold nanoparticle conjugates: Effect of aptamer length on response. Journal of Nanoparticle Research, 2012, 14(10).
DOI Google Scholar
[78]

Sivaraman B., Ramamurthi A., Multifunctional nanoparticles for doxycycline delivery towards localized elastic matrix stabilization and regenerative repair. Acta Biomaterialia, 2013, 9(5): 6511-6525.
DOI Google Scholar
[79]

Freitas S., Merkle H.P., Gander B., Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology. Journal of Controlled Release, 2005, 102(2): 313-323.
DOI Google Scholar
[80]

Mundargi R.C., Babu V.R., Rangaswamy V., et al., Nano/micro technologies for delivering macromolecular therapeutics using poly (D, L-lactide-co-glycolide) and its derivatives. Journal of Controlled Release, 2008, 125(3): 193-209.
DOI Google Scholar
[81]

Song X., Zhao Y., Wu W., et al., PLGA nanoparticles simultaneously loaded with vincristine sulfate and verapamil hydrochloride: Systematic study of particle size and drug entrapment efficiency. International Journal of Pharmaceutics, 2008, 350(1-2): 320-329.
DOI Google Scholar
[82]

Parker J.F., Fields-Zinna C.A., Murray R.W., The story of a monodisperse gold nanoparticle: AU25l 18. Accounts of Chemical Research, 2010, 43(9): 1289-1296.
DOI Google Scholar
[83]

Fernández-Merino M.J., Villar-Rodil S., Paredes J. ., et al., Identifying efficient natural bioreductants for the preparation of graphene and graphene-metal nanoparticle hybrids with enhanced catalytic activity from graphite oxide. Carbon, 2013, 63: 30-44.
DOI Google Scholar
[84]

Medina-Ramirez I., Bashir S., Luo Z., et al., Green synthesis and characterization of polymer-stabilized silver nanoparticles. Colloids and Surfaces B: Biointerfaces, 2009, 73(2): 185-191.
DOI Google Scholar
[85]

Chaudhary R., Nawaz K., Khan A.K., et al., An overview of the algae-mediated biosynthesis of nanoparticles and their biomedical applications. Biomolecules, 2020, 10(11): 1-35.
DOI Google Scholar
[86]

Sardar R., Funston A.M., Mulvaney P., et al., Gold nanoparticles: Past, present, and future. Langmuir, 2009, 25(24): 13840-13851.
DOI Google Scholar
[87]

Noda Y., Noro S.I., Akutagawa T., et al., Gold nanoparticle assemblies stabilized by bis(phthalocyaninato) lanthanide(Ⅲ) complexes through van der Waals interactions. Scientific Reports, 2014, 4: 1-7.
DOI Google Scholar
[88]

Choi S., Jeong Y., Yu J., Spontaneous hydrolysis of borohydride required before its catalytic activation by metal nanoparticles. Catalysis Communications, 2016, 84: 80-84.
DOI Google Scholar
[89]

Pinto V.V., Ferreira M.J., Silva R., et al., Long time effect on the stability of silver nanoparticles in aqueous medium: Effect of the synthesis and storage conditions. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2010, 364(1-3): 19-25.
DOI Google Scholar
[90]
Edvokimov A.A., Mishina E.D., Val'dner V.O., Production and study of nanostructures. BINOM, 2010: 146.
[91]

Patungwasa W., Hodak J.H., pH tunable morphology of the gold nanoparticles produced by citrate reduction. Materials Chemistry and Physics, 2008, 108(1): 45-54.
DOI Google Scholar
[92]

Ravindran A., Chandran P., Khan S.S., Biofunctionalized silver nanoparticles: Advances and prospects. Colloids and Surfaces B: Biointerfaces, 2013, 105: 342-352.
DOI Google Scholar
[93]

Fleming D.A., Thode C.J., Williams M.E., Triazole cycloaddition as a general route for functionalization of Au nanoparticles. Chemistry of Materials, 2006, 18(9): 2327-2334.
DOI Google Scholar
[94]

Ruckenstein E., Li Z.F., Surface modification and functionalization through the self-assembled monolayer and graft polymerization. Advances in Colloid and Interface Science, 2005, 113(1): 43-63.
DOI Google Scholar
[95]

Mulvaney P., Surface plasmon spectroscopy of nanosized metal particles. Langmuir, 1996, 12(3): 788-800.
DOI Google Scholar
[96]

Haruta M., Daté M., Advances in the catalysis of Au nanoparticles. Applied Catalysis A: General, 2001, 222(1-2): 427-437.
DOI Google Scholar
[97]

Brust M., Walker M., Bethell D., et al., Synthesis of Thiol-derivatised Gold Nanoparticles in. Journal of the Chemical Society, Chemical Communications, 1994 : 801-802.
DOI Google Scholar
[98]

Templeton A.C., Wuelfing W.P., Murray R.W., Monolayer-Protected Cluster Molecules. Accounts of Chemical Research, 2000, 33(1): 27-36.
DOI Google Scholar
[99]

Boisselier E., Salmon L., Ruiz J., et al., How to very efficiently functionalize gold nanoparticles by "click" chemistry. Chemical Communications, 2008, (44): 5788-5790.
DOI Google Scholar
[100]

Ghosh P., Han G., De M., et al., Gold nanoparticles in delivery applications. Advanced Drug Delivery Reviews, 2008, 60(11): 1307-1315.
DOI Google Scholar
[101]

Dumur F., Dumas E., Mayer C.R., Functionalization of gold nanoparticles by inorganic entities. Nanomaterials, 2020, 10(3).
DOI Google Scholar
[102]

Salazar-González J.A., González-Ortega O., Rosales-Mendoza S., Gold nanoparticles and vaccine development. Expert Review of Vaccines, 2015, 14(9): 1197-1211.
DOI Google Scholar
[103]

Rana S., Yeh Y.C., Rotello V.M., Engineering the nanoparticle-protein interface: Applications and possibilities. Current Opinion in Chemical Biology, 2010, 14(6): 828-834.
DOI Google Scholar
[104]

Gebregeorgis A., Bhan C., Wilson O., et al., Characterization of Silver/Bovine Serum Albumin (Ag/BSA) nanoparticles structure: Morphological, compositional, and interaction studies. Journal of Colloid and Interface Science, 2013, 389(1): 31-41.
DOI Google Scholar
[105]

Guo J., Zhong R., Li W., et al., Interaction study on bovine serum albumin physically binding to silver nanoparticles: Evolution from discrete conjugates to protein coronas. Applied Surface Science, 2015, 359: 82-88.
DOI Google Scholar
[106]

Banerjee V., Das K.P., Interaction of silver nanoparticles with proteins: A characteristic protein concentration dependent profile of SPR signal. Colloids and Surfaces B: Biointerfaces, 2013, 111: 71-79.
DOI Google Scholar
[107]

Palomino-marcelo L., Gakiya M., Rodriguez-reyes J.C.F., Protocol for Studying the Interaction of Silver Nanoparticles with biomolecules : the case for bovine serum albumin (BSA). 2019, (June).
[108]

Samanta B., Yan H., Fischer N.O., et al., Protein-passivated Fe3O4 nanoparticles: Low toxicity and rapid heating for thermal therapy. Journal of Materials Chemistry, 2008, 18(11): 1204-1208.
DOI Google Scholar
[109]

Aubin-Tam M.E., Hwang W., Hamad-Schifferli K., Site-directed nanoparticle labeling of cytochrome c. Proceedings of the National Academy of Sciences of the United States of America, 2009, 106(11): 4095-4100.
DOI Google Scholar
[110]

Drechsler U., Fischer N.O., Frankamp B.L., et al., Highly efficient biocatalysts via covalent immobilization of Candida rugosa lipase on ethylene glycol-modified gold-silica nanocomposites. Advanced Materials, 2004, 16(3): 271-274.
DOI Google Scholar
[111]

Thorek D.L.J., Elias D.R., Tsourkas A., Comparative analysis of nanoparticle-antibody conjugations: Carbodiimide versus click chemistry. Molecular Imaging, 2009, 8(4): 221-229.
DOI Google Scholar
[112]

Brennan J.L., Hatzakis N.S., Tshikhudo T.R., et al., Bionanoconjugation via click chemistry: The creation of functional hybrids of lipases and gold nanoparticles. Bioconjugate Chemistry, 2006, 17(6): 1373-1375.
DOI Google Scholar
[113]

Brennan J.L., Hatzakis N.S., Tshikhudo T.R., et al., Supporting Information: Bionanoconjugation via click chemistry: The creation of functional hybrids of lipases and gold nanoparticles. Bioconjugate Chemistry, 2006: 1-10.
DOI Google Scholar
[114]

Kim Y.P., Daniel W.L., Xia Z., et al., Bioluminescent nanosensors for protease detection based upon gold nanoparticle-luciferase conjugates. Chemical Communications, 2010, 46(1): 76-78.
DOI Google Scholar
[115]

Zhang M.X., Huang B.H., Sun X.Y., et al., Clickable gold nanoparticles as the building block of nanobioprobes. Langmuir, 2010, 26(12): 10171-10176.
DOI Google Scholar
[116]

Stones D.H., Al-Saedi F., Vaz D., et al., Biomimetic materials to characterize bacteria-host interactions. Journal of Visualized Experiments, 2015, 2015(105): 1-8.
DOI Google Scholar
[117]

Baskin J.M., Prescher J.A., Laughlin S.T., et al., Copper-free click chemistry for dynamic in vivo imaging. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104(43): 16793-16797.
DOI Google Scholar
[118]

Coxon A.C., Stoddart F., Synthesis of a [2]-cryptand with carbon bridgeheads. Carbohydrate Research, 1975, 44(1): 4-7.
DOI Google Scholar
Publication history
Copyright
Acknowledgements
Rights and permissions

Publication history

Received: 05 September 2021
Accepted: 08 May 2022
Published: 12 May 2022
Issue date: March 2022

Copyright

© Andres Arias-Arana, Luis Palomino-Marcelo, Miguel Gakiya-Teruya, Pamela Areche-Vargas, Anand Ramamurthi, and Juan Carlos Rodriguez-Reyes.

Acknowledgements

Acknowledgements

This work has been funded by FONDECYT-CONCYTEC(155-2015-FONDECYT) and by the partnership Cleveland Clinic-Universidad de Ingenieria y Tecnologia-UTEC. Karinna Visurraga and Luz Perez (UTEC) are acknowledged for administrative and technical support. Julio Valdivia, Javier Paino, Marco Málaga and Ana Luisa Alvarez (UTEC), and Vijay Krishna (Cleveland Clinic) are acknowledged for their support through the development of the project. Danae Chipoco and Layla Gonzales (UTEC) are especially thanked for their help in proofreading the manuscript.

Rights and permissions

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Return