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Nano Biomedicine and Engineering 2021, 13(2): 109-126 https://doi.org/10.5101/nbe.v13i2.p109-126
Review | Open Access | Issue | Published: 14 April 2021

Strategies of Nanomaterial Application for Enhanced Wound Curing: An Overview

Show Author's Information Moupriya Nag1,#,  Dibyajit Lahiri1,#,  Sudipta Dash1,  Sayantani Garai1,  Dipro Mukherjee1,  Ritwik Banerjee1,  Rina Rani Ray2( )
Department of Biotechnology, University of Engineering and Management, Kolkata
Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, West Bengal

#Both authors have equal contributions

Keywords:
Nanoparticles, Wound healing, Green synthesis, Cell regeneration
Cite this article:
Nag M, Lahiri D, Dash S, et al. Strategies of Nanomaterial Application for Enhanced Wound Curing: An Overview. Nano Biomedicine and Engineering, 2021, 13(2): 109-126. https://doi.org/10.5101/nbe.v13i2.p109-126
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Abstract Full text About this article

The biological process of healing of wounds deals with the regeneration of cells and is of utmost importance mainly because of the morphological and functional attributes of the tissue. One of the modern approaches is to use novel nanomaterial based wound dressings and other therapeutic treatments that have higher efficiency and specificity. Researchers all around the world have established the competence of various organic, inorganic or polymer-based and biogenically synthesized nanomaterials as a weapon for wound curing. Various matrices carrying nanoparticles like hydrogels, hydrocolloids are used in nano based drug delivery system. The biocompatibility, antimicrobial efficacy and sustained rate of drug delivery are the three main features that are considered for designing a nano drug for effective wound healing. The modification of the nanosized liposome using propylene glycol increases cell-permeation and retention in skin layer. Curcumin loaded liposomes show high anti-inflammatory effect, carbon nanodots (CNDs) and graphene oxide based nanosheets have also shown an immense importance in possessing high surface area. They also show potency in promoting fibroblast growth factors and collagen deposition for speedy recovery of wound. Moreover, the chronic wounds, that could not be cured by common antibiotics, can be addressed by nano based drugs not only for their easy penetration to deeper layer of tissues but also for their efficiency in killing some biofilm associated bacterial strains. Hence, nowadays nano based dressing materials are widely used for rapid recovery of wounds of various types.


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About this article

Strategies of Nanomaterial Application for Enhanced Wound Curing: An Overview

Show Author's information Moupriya Nag1,#, Dibyajit Lahiri1,#, Sudipta Dash1, Sayantani Garai1, Dipro Mukherjee1, Ritwik Banerjee1, Rina Rani Ray2( )
Department of Biotechnology, University of Engineering and Management, Kolkata
Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, West Bengal

#Both authors have equal contributions

Abstract

The biological process of healing of wounds deals with the regeneration of cells and is of utmost importance mainly because of the morphological and functional attributes of the tissue. One of the modern approaches is to use novel nanomaterial based wound dressings and other therapeutic treatments that have higher efficiency and specificity. Researchers all around the world have established the competence of various organic, inorganic or polymer-based and biogenically synthesized nanomaterials as a weapon for wound curing. Various matrices carrying nanoparticles like hydrogels, hydrocolloids are used in nano based drug delivery system. The biocompatibility, antimicrobial efficacy and sustained rate of drug delivery are the three main features that are considered for designing a nano drug for effective wound healing. The modification of the nanosized liposome using propylene glycol increases cell-permeation and retention in skin layer. Curcumin loaded liposomes show high anti-inflammatory effect, carbon nanodots (CNDs) and graphene oxide based nanosheets have also shown an immense importance in possessing high surface area. They also show potency in promoting fibroblast growth factors and collagen deposition for speedy recovery of wound. Moreover, the chronic wounds, that could not be cured by common antibiotics, can be addressed by nano based drugs not only for their easy penetration to deeper layer of tissues but also for their efficiency in killing some biofilm associated bacterial strains. Hence, nowadays nano based dressing materials are widely used for rapid recovery of wounds of various types.

Keywords: Nanoparticles, Wound healing, Green synthesis, Cell regeneration

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Publication history

Received: 10 August 2020
Accepted: 24 January 2021
Published: 14 April 2021
Issue date: June 2021

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© Moupriya Nag, Dibyajit Lahiri, Sudipta Dash, Sayantani Garai, Dipro Mukherjee, Ritwik Banerjee, and Rina Rani Ray.

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