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Nano Biomedicine and Engineering 2020, 12(2): 115-123 https://doi.org/10.5101/nbe.v12i2.p115-123
Research Article | Open Access | Issue | Published: 14 April 2020

In-vivo Toxicological (Acute) Characterization of Bio-synthesized Silver Nanoparticles in Labeo rohita

Show Author's Information Jayaraju Jeyasree1,  Giridharan Bupesh3,7( ),  Sakthivel Vasanth3,  Joseph Pinto Jasmine Beulah3,  Kanniayah Pandian5,  Arumugam Vijaya Anand6,  Tharumasivam Shiva Vijayakumar4,  Lakshmi Narayanan2
Department of Biotechnology, Bharath College of Science and Management, Thanjavur, TN, India
Department of Biotechnology, Thanthai Hans Roever College, Perambalur TN, India
R&D wing, Sree Balaji Medical College and Hospital, Chromepet, Chennai-600044 TN, India
Department of Biotechnology, Srimath Andavan College, Tiruchirappalli, TN, India
Department of Inorganic Chemistry, University of Madras, Guindy Campus, Tamil Nadu, India
Department of Human Genetics and Molecular Biology, Bharathiyar University, Coimabatore, India
Department of Forest Science, Central University of Nagaland, Lumami, India
Keywords:
Antioxidant, Silver nanoparticles, Nanotoxicity, Acute toxicity, Labeo rohita, Haematological, Histopathology
Cite this article:
Jeyasree J, Bupesh G, Vasanth S, et al. In-vivo Toxicological (Acute) Characterization of Bio-synthesized Silver Nanoparticles in Labeo rohita. Nano Biomedicine and Engineering, 2020, 12(2): 115-123. https://doi.org/10.5101/nbe.v12i2.p115-123
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Abstract Full text About this article

This study extensively investigated to find out the in-vivo acute toxicity and lethal concentration (LC50) of biosynthesized Ag NPs in Labeo rohita (L. rohita). The haematological studies and antioxidative responses were considered in three tissues such as gill, liver and muscle of L. rohita. The results of this study showed that increasing the dose of Ag NPs led to bioaccumulation in the tissues. The haematological analysis showed considerable alterations in the Ag NPs-treated fish. The impact of histological changes induced by Ag NPs were confirmed by the damages in the tissues, primary lamella, blood vessels and formation of vacuolation in liver and muscle when compared with the control L. rohita.


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In-vivo Toxicological (Acute) Characterization of Bio-synthesized Silver Nanoparticles in Labeo rohita

Show Author's information Jayaraju Jeyasree1, Giridharan Bupesh3,7( ), Sakthivel Vasanth3, Joseph Pinto Jasmine Beulah3, Kanniayah Pandian5, Arumugam Vijaya Anand6, Tharumasivam Shiva Vijayakumar4, Lakshmi Narayanan2
Department of Biotechnology, Bharath College of Science and Management, Thanjavur, TN, India
Department of Biotechnology, Thanthai Hans Roever College, Perambalur TN, India
R&D wing, Sree Balaji Medical College and Hospital, Chromepet, Chennai-600044 TN, India
Department of Biotechnology, Srimath Andavan College, Tiruchirappalli, TN, India
Department of Inorganic Chemistry, University of Madras, Guindy Campus, Tamil Nadu, India
Department of Human Genetics and Molecular Biology, Bharathiyar University, Coimabatore, India
Department of Forest Science, Central University of Nagaland, Lumami, India

Abstract

This study extensively investigated to find out the in-vivo acute toxicity and lethal concentration (LC50) of biosynthesized Ag NPs in Labeo rohita (L. rohita). The haematological studies and antioxidative responses were considered in three tissues such as gill, liver and muscle of L. rohita. The results of this study showed that increasing the dose of Ag NPs led to bioaccumulation in the tissues. The haematological analysis showed considerable alterations in the Ag NPs-treated fish. The impact of histological changes induced by Ag NPs were confirmed by the damages in the tissues, primary lamella, blood vessels and formation of vacuolation in liver and muscle when compared with the control L. rohita.

Keywords: Antioxidant, Silver nanoparticles, Nanotoxicity, Acute toxicity, Labeo rohita, Haematological, Histopathology

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Publication history

Received: 21 January 2020
Accepted: 14 April 2020
Published: 14 April 2020
Issue date: June 2020

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© Jayaraju Jeyasree, Giridharan Bupesh, Sakthivel Vasanth, Joseph Pinto Jasmine Beulah, Kanniayah Pandian, Arumugam Vijaya Anand, Tharumasivam Shiva Vijayakumar, and Lakshmi Narayanan.

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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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