Journal Home > Volume 11 , Issue 4
Nano Biomedicine and Engineering 2019, 11(4): 375-380 https://doi.org/10.5101/nbe.v11i4.p375-380
Research Article | Open Access | Issue | Published: 11 December 2019

Zinc Oxide Nanoparticles and Nanorods as Antimicrobial Agents: Particle Size Influence

Show Author's Information Araa Mebdir Holi1( ),  Sadiyha Yasir Offi Al-Jubory2
Department of Physics, College of Education, University of Al-Qadisiyah, Al-Diwaniyah, Al-Qadisiyah, 58002, Iraq
Department of Agricultural Biotechnology, College of Biotechnology, University of Al-Qadisiyah, Al-Diwaniyah, Al-Qadisiyah, 58002, Iraq
Keywords:
Particle size, Antibacterial activity, ZnO nanorods, ZnO nanoparticles
Cite this article:
Holi AM, Al-Jubory SYO. Zinc Oxide Nanoparticles and Nanorods as Antimicrobial Agents: Particle Size Influence. Nano Biomedicine and Engineering, 2019, 11(4): 375-380. https://doi.org/10.5101/nbe.v11i4.p375-380
Download citation
EndNote(RIS)
BibTeX

481

Views

23

Downloads

Citations

1

Crossref

N/A

WoS

2

Scopus

N/A

CSCD

Abstract Full text About this article

The aim of this study is to find out about the antibacterial activity of a variety of ZnO nanostructures, along with their derivative nanoparticles (ZnO NPs) and nanorods (ZnO NRs) against numerous clinic strains of Gram-negative Escherichia coli (E. coli), Salmonella typhi (S. typhi), Pseudomonas aeruginosa (P. aeruginosa) as well as Gram-positive Streptococcus pneumonia (Strept. pneumonia) bacteria. ZnO NPs and ZnO NRs were efficiently synthesized by using sol-gel and hydrothermal strategies, respectively. Various properties, consisting of the morphology, structure and optical, had been described by using field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD) as well as ultraviolet-visible (UV-Vis) spectroscopy analysis. This check was performed in Mueller-Hinton agar. The impact of different particle sizes and morphologies of ZnO nanomaterials on the growth of bacteria was measured. In the antibacterial assay, each type of ZnO nanostructure showed effective inhibition. The findings showed that ZnO NRs exhibited more efficient antibacterial activity than that of ZnO NPs agents. This was once the case for both Gram-positive and Gram-negative bacteria. Hence, the study indicated that the antibacterial of ZnO NRs against Strept. Pneumonia was similar to those for S. typhi. However, depending on the particle size effect of ZnO nanostructure, it was found that ZnO NPs showed much less antibacterial activity towards S. typhi than ZnO NRs did.


menu
Abstract
Full text
Outline
About this article

Zinc Oxide Nanoparticles and Nanorods as Antimicrobial Agents: Particle Size Influence

Show Author's information Araa Mebdir Holi1( ), Sadiyha Yasir Offi Al-Jubory2
Department of Physics, College of Education, University of Al-Qadisiyah, Al-Diwaniyah, Al-Qadisiyah, 58002, Iraq
Department of Agricultural Biotechnology, College of Biotechnology, University of Al-Qadisiyah, Al-Diwaniyah, Al-Qadisiyah, 58002, Iraq

Abstract

The aim of this study is to find out about the antibacterial activity of a variety of ZnO nanostructures, along with their derivative nanoparticles (ZnO NPs) and nanorods (ZnO NRs) against numerous clinic strains of Gram-negative Escherichia coli (E. coli), Salmonella typhi (S. typhi), Pseudomonas aeruginosa (P. aeruginosa) as well as Gram-positive Streptococcus pneumonia (Strept. pneumonia) bacteria. ZnO NPs and ZnO NRs were efficiently synthesized by using sol-gel and hydrothermal strategies, respectively. Various properties, consisting of the morphology, structure and optical, had been described by using field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD) as well as ultraviolet-visible (UV-Vis) spectroscopy analysis. This check was performed in Mueller-Hinton agar. The impact of different particle sizes and morphologies of ZnO nanomaterials on the growth of bacteria was measured. In the antibacterial assay, each type of ZnO nanostructure showed effective inhibition. The findings showed that ZnO NRs exhibited more efficient antibacterial activity than that of ZnO NPs agents. This was once the case for both Gram-positive and Gram-negative bacteria. Hence, the study indicated that the antibacterial of ZnO NRs against Strept. Pneumonia was similar to those for S. typhi. However, depending on the particle size effect of ZnO nanostructure, it was found that ZnO NPs showed much less antibacterial activity towards S. typhi than ZnO NRs did.

Keywords: Particle size, Antibacterial activity, ZnO nanorods, ZnO nanoparticles

References(40)

[1]

G. Sangeetha, R. Sivaraj, and V. Rajendran, Green synthesized ZnO nanoparticles against bacterial and fungal pathogens. Progress in Natural Science: Materials International, 2012, 22: 693-700.
DOI Google Scholar
[2]

J. Pragati, P. Khatri, and J.S. Rana, Green synthesis of zinc oxide nanoparticles using flower extract of Nyctanthes arbor-tristis and their antifungal activity. Journal of King Saud University-Science, 2018, 30: 168-175.
DOI Google Scholar
[3]

R. Kimia, M. Etemadzade, R. Farhoudi, et al., Fe3+-EDTA-zinc oxide nano-diagnostics: Synthesis and in vitro cellular evaluation. An International Peer Reviewed Open Access Journal for Rapid Publication, 2017: 445.
Google Scholar
[4]

J. Jinhuan, J. Pi, and J. Cai, The advancing of zinc oxide nanoparticles for biomedical applications. Bioinorganic chemistry and applications, 2018, 2018.
DOI Google Scholar
[5]

K.I. Bogutska, Y.P. Sklyarov, and Y.I. Prylutskyy, Zinc and zinc nanoparticles: biological role and application in biomedicine. Ukrainica Bioorganica Acta, 2013, 1: 9-16.
Google Scholar
[6]

K. Rajesh, A. Umar, G. Kumar, et al., Antimicrobial properties of ZnO nanomaterials. A review Ceramics International, 2017, 43: 3940-3961.
DOI Google Scholar
[7]

K. Cheol-Su, H.D. Nguyen, R.M. Ignacio, et al., Immunotoxicity of zinc oxide nanoparticles with different size and electrostatic charge. International Journal of Nanomedicine, 2014, 9: 195.
DOI Google Scholar
[8]

P. Uikey, K. Vishwakarma, Review of zinc oxide (ZnO) nanoparticles applications and properties. International Journal of Emerging Technology in Computer Science & Electronics, 2016, 21: 239.
Google Scholar
[9]

M.M. Abd Elhady, Preparation and characterization of chitosan/zinc oxide nanoparticles for imparting antimicrobial and UV protection to cotton fabric. International Journal of Carbohydrate Chemistry, 2012, 2012.
DOI Google Scholar
[10]

S. Noothongkaew, S. Pukird, W. Sukkabot, et al., Zinc oxide nanostructures synthesized by thermal oxidation of zinc powder on Si substrate. Applied Mechanics and Materials, 2013, 328: 710-714.
DOI Google Scholar
[11]

A.M. Holi, Z. Zainal, Z.A. Talib, et al., Effect of hydrothermal growth time on ZnO nanorod arrays photoelectrode performance. Optik, 2016, 127: 11111-11118.
DOI Google Scholar
[12]

Y.Y. Villanueva, D.R. Liu, and P.T. Cheng, Pulsed laser deposition of zinc oxide. Thin Solid Films, 2006, 501: 366-369.
DOI Google Scholar
[13]

J. Zhang, T. Liu, Y. Zhang, et al., Hydrothermal synthesis and growth mechanisms of different ZnO nanostructures and their gas-sensing properties. Journal of Materials Science: Materials in Electronics, 2015, 26: 1347-1353.
DOI Google Scholar
[14]
Z. Chen, K. Shum, T. Salagaj, et al., ZnO thin films synthesized by chemical vapor deposition. Proceedings of the 2010 IEEE Long Island Systems, Applications and Technology Conference, 2010: 1-6.
[15]

A. Goux, T. Pauporté, J. Chivot, et al., Temperature effects on ZnO electrodeposition. Electrochimica Acta, 2005, 50: 2239-2248.
DOI Google Scholar
[16]

T. Shimomura, D. Kim, and M. Nakayama, Optical properties of high-quality ZnO thin films grown by a sputtering method. Journal of Luminescence, 2005, 112: 191-195.
DOI Google Scholar
[17]

O. Yamamoto, Influence of particle size on the antibacterial activity of zinc oxide. International Journal of Inorganic Materials, 2001, 3: 643-646.
DOI Google Scholar
[18]

A. Sirelkhatim, S. Mahmud, A. Seeni, et al., Review on zinc oxide nanoparticles: antibacterial activity and toxicity mechanism. Nano-Micro Letters, 2015, 7: 219-242.
DOI Google Scholar
[19]

V. Tiwari, N. Mishra, K. Gadani, et al., Mechanism of anti-bacterial activity of zinc oxide nanoparticle against carbapenem-resistant Acinetobacter baumannii. Frontiers in Microbiology, 2018, 9: 1218.
DOI Google Scholar
[20]

E.P.J. Perez, N.D.F. Soares, J.S.D.R. Coimbra, et al., Zinc oxide nanoparticles: synthesis, antimicrobial activity and food packaging applications. Food and Bioprocess Technology, 2012, 5 : 1447-1464.
DOI Google Scholar
[21]

Y. Liu, L. He, A. Mustapha, et al., Antibacterial activities of zinc oxide nanoparticles against Escherichia coli O157: H7. Journal of Applied Microbiology, 2009, 107: 1193-1201.
DOI Google Scholar
[22]

S.R. Senthilkumar, T. Sivakumar, Green tea (Camellia sinensis) mediated synthesis of zinc oxide (ZnO) nanoparticles and studies on their antimicrobial activities. Int. J. Pharm. Pharm. Sci., 2014, 6: 461-465.
Google Scholar
[23]
B. Fisher, R.P. Harvey, and P.C. Champe, Lippincott›s illustrated reviews: Microbiology. Lippincott's illustrated reviews series. Lippincott Williams & Wilkins, 2007: 367-392.
[24]

F. Baquero, M.T. Coque, and F. Cruz, Ecology and evolution as targetsthe need for novel Eco-Evo drugs and strategies to fight antibiotic resistance. Antimicrob. Agents Ch., 2011, 55: 3649-3660.
DOI Google Scholar
[25]

R.J. Fair, Y. Tor, Antibiotics and bacterial resistance in the 21st century. Perspectives in Medicinal Chemistry, 2014, 6: PMC-S14459.
DOI Google Scholar
[26]

Q.H. Yu, Z.S. Wang, and Q. Yang, Ability of Lactobacillus to inhibit enteric pathogenic bacteria adhesion on Caco-2 cells. World J. Microbiol. Bio. Technol., 2012, 27: 881-886.
DOI Google Scholar
[27]

M.S. Jabir, U.M. Nayef, A. Kadhim, et al., Polyethylene glycol-functionalized magnetic (Fe3O4) nanoparticles: A novel DNA-mediated antibacterial agent. Nano Biomedicine & Engineering, 2019, 11: 18-27.
DOI Google Scholar
[28]

M.S. Jabir, A.A. Taha, and U.I. Sahib, Linalool loaded on glutathione-modified gold nanoparticles: A drug delivery system for a successful antimicrobial therapy. Artificial Cells, Nanomedicine, and Biotechnology, 2018, 46: 345-355.
DOI Google Scholar
[29]

Y.N. Slavin, J. Asnis, U.O. Häfeli, et al., Metal nanoparticles: understanding the mechanisms behind antibacterial activity. Journal of Nanobiotechnology, 2017, 15: 65.
DOI Google Scholar
[30]

K.S. Siddiqi, A. Ur Rahman, and A. Husen, Properties of zinc oxide nanoparticles and their activity against microbes. Nanoscale research Letters, 2018, 13: 141.
DOI Google Scholar
[31]

Y. Xie, Y. He, P.L. Irwin, et al., Antibacterial activity and mechanism of action of zinc oxide nanoparticles against Campylobacter jejuni. Appl. Environ. Microbiol, 2011, 77: 2325-2331.
DOI Google Scholar
[32]

J.T. Seil, T.J. Webster, Antimicrobial applications of nanotechnology: Methods and literature. International Journal of Nanomedicine, 2012, 7: 2767.
DOI Google Scholar
[33]

B. Sadeghi, M. Jamali, S. Kia, et al., Synthesis and characterization of silver nanoparticles for antibacterial activity. International Journal of Nano Dimension, 2010, 1: 119-124.
Google Scholar
[34]
V.V. Kumar, S.P. Anthony, Antimicrobial studies of metal and metal oxide nanoparticles. Surface chemistry of nanobiomaterials. William Andrew Publishing, 2016: 265-300.
DOI
[35]

N. Jones, B. Ray, K.T. Ranjit, et al., Antibacterial activity of ZnO nanoparticle suspensions on a broad spectrum of microorganisms. FEMS Microbiology Letters, 2008, 279: 71-76.
DOI Google Scholar
[36]

L. Zhang, Y. Jiang, and Y. Ding, Investigation into the antibacterial behaviour of suspensions of ZnO nanoparticles (ZnO nanofluids). Journal of Nanoparticle Research, 2007, 9: 479-489.
DOI Google Scholar
[37]

T. Ohira, O. Yamamoto, Y. Iida, et al., Antibacterial activity of ZnO powder with crystallographic orientation. Journal of Materials Science: Materials in Medicine, 2008, 19: 1407-1412.
DOI Google Scholar
[38]

G. Applerot, A. Lipovsky, R. Dror, et al., Enhanced antibacterial activity of nanocrystalline ZnO due to increased ROS-mediated cell injury. Advanced Functional Materials, 2009, 19: 842-852.
DOI Google Scholar
[39]

K.R. Raghupathi, R.T. Koodali, et al., Size-dependent bacterial growth inhibition and mechanism of antibacterial activity of zinc oxide nanoparticles. Langmuir, 2011, 27: 4020-4028.
DOI Google Scholar
[40]

K.H. Tam, A.B. Djurišić, C.M.N. Chan, et al., Antibacterial activity of ZnO nanorods prepared by a hydrothermal method. Thin Solid Films, 2005, 516: 6167-6174.
DOI Google Scholar
Publication history
Copyright
Acknowledgements
Rights and permissions

Publication history

Received: 11 November 2019
Accepted: 10 December 2019
Published: 11 December 2019
Issue date: December 2019

Copyright

© Araa Mebdir Holi, Sadiyha Yasir Offi Al-Jubory.

Acknowledgements

Acknowledgements

We thank the University of Al-Qadisiyah/College of Education and College of Biotechnology/Ministry of Higher Education and Scientific Research of Iraq for finical supportfor this study. Special thanks are extended to Diwaniyah Teaching Hospital.

Rights and permissions

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Return