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Research Article | Open Access

Rifampicin: Electrochemical Effect on Blood Component by Cyclic Voltammetry Using Nano-Sensor

Muhammed Mizher Radhi1( ), Anfal Ismael Ibrahim2, Yousif Kadhim Al-Haidarie2, Sura Ali Al-Asadi1, Emad Abbas Jaffar Al-Mulla3
Radiological Techniques Department, Health and Medical Technology College-Baghdad, Middle Technical University (MTU), Iraq
Chemistry Department, Science College, Al-mustansiriyah University, Iraq
Babylon Technical Institute, Al-Furat Al-Awsat Technical University, 51015 Babylon, Iraq
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Abstract

Rifampicin (RIF) compound was analyzed by electrochemical study using cyclic voltammetric method to characterize the electrochemical properties in blood medium. Glassy carbon electrode (GCE) was modified with carbon nanotubes (CNT) as a high sensitive sensor for using in the electro-analysis of RIF in blood medium. It was found that oxidation and reduction current peaks of RIF in blood medium were at the potential of 0.5 and -0.5 V, respectively. Different concentrations, pH, scan rates, reliability and stability of RIF in blood medium were studied. The diffusion coefficient of oxidation and reduction was determined using the Randles-Seveik equation. The result showed the average value of oxidation and reduction were 2.66 × 10-5 and 8.72 × 10-5 cm2s-1, respectively.

Keywords

RifampicinBlood mediumCyclic voltammetryCNT/GCE

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Nano Biomedicine and Engineering
Volume 11 Issue 2,
June 2019
Pages 150-156
DOI: 10.5101/nbe.v11i2.p150-156

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Cite this article:
Mizher Radhi M, Ismael Ibrahim A, Al-Haidarie YK, et al. Rifampicin: Electrochemical Effect on Blood Component by Cyclic Voltammetry Using Nano-Sensor. Nano Biomedicine and Engineering, 2019, 11(2): 150-156. https://doi.org/10.5101/nbe.v11i2.p150-156

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Received: 28 July 2018
Accepted: 09 April 2019
Published: 30 April 2019
© Muhammed Mizher Radhi, Anfal Ismael Ibrahim, Yousif Kadhim Al-Haidarie, Sura Ali Al-Asadi, and Emad Abbas Jaffar Al-Mulla i.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.