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Research Article | Open Access

Lipschitz stability analysis of fractional-order gene regulatory networks with impulsive perturbations and distributed delays

Ivanka Stamova1( )Cvetelina Spirova2Gani Stamov1
Department of Mathematics, University of Texas at San Antonio, San Antonio, TX 78249, USA
Department of Mathematics, Technical University of Sofia, Sliven 8800, Bulgaria
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Abstract

A model of fractional-order discontinuous impulsive delayed gene regulatory networks (GRNs) was investigated in this paper. The impulsive perturbations were at fixed moments of time and measured the impulsive control effects which can be controlled appropriately. A fractional-order modeling approach was applied and distributed delays were taken into account for greater model flexibility. In this paper, rather than studying the classical Lyapunov-type stability of an equilibrium point, we addressed the extended Lipschitz stability behavior of the considered GRNs. By applying the impulsive fractional Lyapunov functions technique, new criteria were derived to ensure the global uniform Lipschitz stability for the fractional impulsive delayed GRNs. Furthermore, the effects of considering uncertain parameters were also analyzed. Finally, an illustrating example was given to support the obtained theoretical results.

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Mathematical Modelling and Control
Pages 421-431

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Cite this article:
Stamova I, Spirova C, Stamov G. Lipschitz stability analysis of fractional-order gene regulatory networks with impulsive perturbations and distributed delays. Mathematical Modelling and Control, 2025, 5(4): 421-431. https://doi.org/10.3934/mmc.2025030

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Received: 26 September 2025
Revised: 18 October 2025
Accepted: 20 October 2025
Published: 15 December 2025
©2025 the Author(s), licensee AIMS Press.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0)