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This paper proposes a model that eliminates combined additive and multiplicative noise by merging the Rudin, Osher, and Fatemi (ROF) and I-divergence data fidelity terms. Many important techniques for denoising and restoring medical images were included in this model. The addition of the I-divergence fidelity term increases the complexity of the model and difficulty of the solution in comparison with the ROF. To solve this model, we first proposed the generalized concept of the maximum common factor based on the inverse scale space algorithm. Different from general denoising algorithms, the inverse scale space method exploits the fact that
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