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This study examines the influence of drought on predator–prey systems under the variable-order (VO) fractional derivative. It is applied to the wildebeest–lion system of the Serengeti. First, the well-posedness of the system is ensured by the existence, uniqueness, and Ulam–Hyers (UH) stability of the solution. A finite difference method is presented, coupled with a neural network (NN) approach for numerical validation. The numerical results show the effect of the VO fractional derivative and the intensity of the drought. The results demonstrate that a critical drought threshold exists for the drought impact parameter
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