Mathematical modeling of alcohol-induced effects on bone remodeling dynamics

This study develops a mathematical model to investigate the impact of alcohol consumption on bone remodeling dynamics, thereby focusing on osteoclast, osteoblast, and bone mass interactions. Extending Komarova's framework, the model incorporates alcohol-dependent regulatory factors which influence cell proliferation and apoptosis. Analytical methods are used to determine the steady states and assess the local stability via the Jacobian matrix, while numerical simulations in MATLAB illustrate the system behavior under varying alcohol levels. The results show that moderate alcohol intake supports stable and periodic remodeling, whereas excessive or insufficient consumption disrupts the equilibrium, which leads to bone loss. These findings provide quantitative insights into alcohol-induced bone disorders and highlight the importance of maintaining moderate alcohol consumption for skeletal health.