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Research Article | Open Access

Mathematical analysis of neurological disorder under fractional order derivative

Nadeem Khan1Amjad Ali1Aman Ullah2Zareen A. Khan3( )
Department of Basic Sciences & Islamiat, University of Engineering and Technology, Peshawar, Pakistan
Department of Mathematics, University of Malakand, Dir(L), Khyber Pakhtunkhwa, Pakistan
Department of Mathematical Sciences, College of Science, Princess Nourah bint Abdulrahman University, P. O. Box 84428, Riyadh 11671, Saudi Arabia
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Abstract

Multiple sclerosis (MS) is a common neurological disorder that affects the central nervous system (CNS) and can cause lesions that spread over space and time. Our study proposes a mathematical model that illustrates the progression of the disease and its likelihood of recurrence. We use Caputo fractional-order (FO) derivative operators to represent non-negative solutions and to establish a steady-state point and basic reproductive number. We also employ functional analysis to prove the existence of unique solutions and use the Ulam-Hyres (UH) notion to demonstrate the stability of the solution for the proposed model. Furthermore, we conduct numerical simulations using an Euler-type numerical technique to validate our theoretical results. Our findings are presented through graphs that depict various behaviors of the model for different parameter values.

CLC number: 26A33, 34K37

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AIMS Mathematics
Pages 18846-18865

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Cite this article:
Khan N, Ali A, Ullah A, et al. Mathematical analysis of neurological disorder under fractional order derivative. AIMS Mathematics, 2023, 8(8): 18846-18865. https://doi.org/10.3934/math.2023959

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Received: 14 March 2023
Revised: 25 April 2023
Accepted: 27 April 2023
Published: 15 August 2023
©2023 the Author(s), licensee AIMS Press.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0)