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Using the theory of Lie-Hamilton systems, formal generalized time-dependent Hamiltonian systems that extend a recently proposed SIS epidemic model with a variable infection rate are considered. It is shown that, independently on the particular interpretation of the time-dependent coefficients, these systems generally admit an exact solution, up to the case of the maximal extension within the classification of Lie-Hamilton systems, for which a superposition rule is constructed. The method provides the algebraic frame to which any SIS epidemic model that preserves the above-mentioned properties is subjected. In particular, we obtain exact solutions for generalized SIS Hamiltonian models based on the book and oscillator algebras, denoted by
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