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Research Article | Open Access

Dynamical behavior of tumor-immune system with fractal-fractional operator

Muhammad Farman1Aqeel Ahmad2Ali Akgül3Muhammad Umer Saleem4Kottakkaran Sooppy Nisar5( )Velusamy Vijayakumar6
Department of Mathematics and Statistics, University of Lahore, Lahore-54590, Pakistan
Department of Mathematics, Ghazi University, D. G. Khan, Pakistan
Art and Science Faculty, Department of Mathematics, Siirt University, 56100 Siirt, Turkey
Department of Mathematics, University of Education, Lahore-54590, Pakistan
Department of Mathematics, College of Arts and Sciences, Wadi Aldawaser, Prince Sattam bin Abdulaziz University, Saudi Arabia
Department of Mathematics, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632014, Tamilnadu, India
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Abstract

In this paper, the dynamical behavior of the fractional-order cancer model has been analyzed with the fractal-fractional operator, which discretized the conformable cancer model. The fractional-order model consists of the system of nonlinear fractional differential equations. Also, we discuss the fractional-order model to check the relationship between the immune system and cancer cells by mixing IL-12 cytokine and anti-PD-L1 inhibitor. The tumor-immune model has been studied qualitatively as well as quantitatively via Atangana-Baleanu fractal-fractional operator. The nonlinear analysis is used to check the Ulam-Hyres stability of the proposed model. Moreover, the dynamical behavior for the fractional-order model has been checked by using a fractal-fractional operator with a generalized Mittag-Leffler Kernel and verifying the effect of fractional parameters. Finally, the obtained solutions are interpreted biologically, and simulations are carried out to illustrate cancer disease and support theoretical results, which will be helpful for further analysis and to control the effect of cancer in the community.

CLC number: 37C75, 93B05, 65L07

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AIMS Mathematics
Pages 8751-8773

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Cite this article:
Farman M, Ahmad A, Akgül A, et al. Dynamical behavior of tumor-immune system with fractal-fractional operator. AIMS Mathematics, 2022, 7(5): 8751-8773. https://doi.org/10.3934/math.2022489

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Received: 17 October 2021
Revised: 10 January 2022
Accepted: 08 February 2022
Published: 15 May 2022
©2022 the Author(s), licensee AIMS Press.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0)