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Review | Open Access

RP11-Derived Long Non-Coding RNAs in Hepatocellular Carcinoma: Hidden Treasures in Plain Sight

Se Ha Jang#,1,2, Hyung Seok Kim#,3, Jung Woo Eun1( )
Department of Gastroenterology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, Republic of Korea
Department of Biomedical Sciences, Ajou University Graduate School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, Republic of Korea
Department of Biochemistry, Kosin University College of Medicine, Seo-gu, Busan, 49267, Republic of Korea

#These authors contributed equally to this work

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Abstract

Hepatocellular carcinoma (HCC) remains one of the most prevalent and lethal malignancies worldwide. Long non-coding RNAs (lncRNAs) have emerged as crucial regulators of gene expression and cancer progression, yet the functional diversity of RP11-derived lncRNAs—originally mapped to bacterial artificial chromosome (BAC) clones from the Roswell Park Cancer Institute—has only recently begun to be appreciated. This mini-review aims to systematically synthesize current findings on RP11-derived lncRNAs in HCC, outlining their genomic origins, molecular mechanisms, and biological significance. We highlight their roles in metabolic reprogramming, microRNA network modulation, and tumor progression, as well as their diagnostic and prognostic value in tissue and serum-based analyses. Finally, we discuss therapeutic opportunities and propose future directions to translate RP11-derived lncRNAs into clinically actionable biomarkers and targets for precision liver cancer therapy.

Keywords

Hepatocellular carcinomalong non-coding RNARP11-derived lncRNAbiomarkertherapeutic target

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Oncology Research
Volume 34 Issue 1,
December 2026
Article number: 5
DOI: 10.32604/or.2025.072240

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Cite this article:
Jang SH, Kim HS, Eun JW. RP11-Derived Long Non-Coding RNAs in Hepatocellular Carcinoma: Hidden Treasures in Plain Sight. Oncology Research, 2026, 34(1): 5. https://doi.org/10.32604/or.2025.072240

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Received: 22 August 2025
Accepted: 30 October 2025
Published: 30 December 2025
© The Author 2026.

This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.