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Lassa Fever (LF) is a viral hemorrhagic illness transmitted via rodents and is endemic in West Africa, causing thousands of deaths annually. This study develops a dynamic model of Lassa virus transmission, capturing the progression of the disease through susceptible, exposed, infected, and recovered populations. The focus is on simulating this model using the fractional Caputo derivative, allowing both qualitative and quantitative analyses of boundedness, positivity, and solution uniqueness. Fixed-point theory and Lipschitz conditions are employed to confirm the existence and uniqueness of solutions, while Lyapunov functions establish the global stability of both disease-free and endemic equilibria. The study further examines the role of the Caputo operator by solving the generalized power-law kernel via a two-step Lagrange polynomial method. This approach offers practical advantages in handling additional data points in integral forms, though Newton polynomial-based schemes are generally more accurate and can outperform Lagrange-based Adams-Bashforth methods. Graphical simulations validate the proposed numerical approach for different fractional orders (
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