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Hybrid nanofluids have gained significant attention for their superior thermal and rheological characteristics, offering immense potential in energy conversion, biomedical transport, and electromagnetic flow control systems. Understanding their dynamic behavior under coupled magnetic, rotational, and reactive effects is crucial for the development of efficient thermal management technologies. This study develops a neuro-fuzzy computational framework to examine the dynamics of a reactive Cu–TiO2–H2O hybrid nanofluid flowing through a squarely elevated Riga tunnel. The governing model incorporates Hall and ion-slip effects, thermal radiation, and first-order chemical reactions under ramped thermo-solutal boundary conditions and rotational electromagnetic forces. Closed-form analytical solutions are derived via the Laplace transform method to describe the transient velocity, temperature, and concentration fields. To complement and validate the analytical model, an artificial neural network (ANN) optimized using the Levenberg–Marquardt backpropagation algorithm (ANN-LMBPA) is trained on datasets generated in Mathematica. Regression and error analyses confirm the model’s predictive robustness, with mean squared errors ranging between
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