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Article | Open Access

Negative-One-Day Malware Detection with Generative AI: A Stable Diffusion-Based Proactive Defense Framework

Sohail Khan1( )Toqeer Ali Syed2Mohammad Nauman1Salman Jan3It Ee Lee4Qamar Wali4
Department of Computer Science, Effat College of Engineering, Effat University, Jeddah, Saudi Arabia
Faculty of Computer and Information System, Islamic University of Madinah, Madinah, Saudi Arabia
Faculty of Computer Studies, Arab Open University, A’Ali, Bahrain
Faculty of Artificial Intelligence and Engineering, Multimedia University, Cyberjaya, Malaysia
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Abstract

The detection of zero-day malware represents one of the most significant challenges in contemporary cybersecurity. In this paper, we introduce a novel concept called “Negative-One-Day Malware Detection”, which aims to identify potentially malicious software before it is actually created by threat actors. Our approach leverages recent advancements in generative AI, specifically diffusion-based generative models, to generate and analyze potential future malware variants. By doing so, we can train detection systems to recognize these variants before they emerge in the wild, thereby closing the critical protection gap that currently exists between malware creation and detection. We demonstrate the effectiveness of our approach through extensive experimentation, showing that our framework can generate executable malware samples that combine characteristics from different families while exhibiting novel behaviors. These synthetically generated samples significantly improve the detection capabilities of security systems when incorporated into training data, providing a proactive rather than reactive approach to cybersecurity.

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Computers, Materials & Continua

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Cite this article:
Khan S, Syed TA, Nauman M, et al. Negative-One-Day Malware Detection with Generative AI: A Stable Diffusion-Based Proactive Defense Framework. Computers, Materials & Continua, 2026, 88(1). https://doi.org/10.32604/cmc.2026.075265

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Received: 28 October 2025
Accepted: 31 March 2026
Published: 08 May 2026
© The Author 2026.

This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.