As a reservoir reaches depletion stage there will still be a varying amount of residual oil saturation in the reservoir pore volume that is too heavy to be moved and produced. This undesirable phenomenon occurs due to adverse mobility and/or viscosity ratio between displacing phase (water) and displaced phase (residual oil). A solution to that is polymer injection which has been considered as one of the most effective and successful method to improve oil recovery. Moreover polymer flooding also showed limited success when applied in heterogeneous reservoir. This is because single polymer injection cannot sweep entire porous media efficiently, therefore in this research work the effectiveness of sequential polymer injection is studied and compared with conventional single polymer injection. The reservoir property model was developed from the available well data of an example field using stochastic approach. From the base case two more property models were developed to cover the heterogeneity from slightly to very heterogeneous reservoir rock. The degree of heterogeneity was obtained for each property model using DykstraParson technique. The magnitude of Dykstra-Parson coefficient for Slightly, Moderate and Very heterogeneous were 0.24, 0.59 and 0.69, respectively. Our results indicated that injecting polymers sequentially with varying in concentrations is an effective technique for enhanced oil recovery in heterogeneous reservoir rock.