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Stress and Brain 2024, 4(1): 31-45 https://doi.org/10.26599/SAB.2023.9060007
Review Article | Open Access | Issue | Published: 05 March 2024

An overview of mechanisms underlying the comorbidity of sleep and depression disorders in the elderly

Show Author's Information Yuan Yao1,2,  Dan Guo1,2,  Fang-Lin Liu1,2,  Ying Han1( )
National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing 100191, China
School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China
Keywords:
depression, neurocircuits, aging, sleep, clock system, neurochemical substrates
Cite this article:
Yao Y, Guo D, Liu F-L, et al. An overview of mechanisms underlying the comorbidity of sleep and depression disorders in the elderly. Stress and Brain, 2024, 4(1): 31-45. https://doi.org/10.26599/SAB.2023.9060007
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Abstract Full text About this article

Sleep disruption is common in older adults and has been linked to many negative health outcomes, including impaired cognitive, emotional, and interpersonal functioning and maladaptive metabolic changes. Sleep disturbance is the most common symptom in depressive patients, and it was formerly thought to be a major secondary manifestation of depression. Many longitudinal studies have identified insomnia as an independent risk factor for the development of emerging or recurrent depression in older adults, with bidirectional relationships between sleep quality and depression. This narrative review summarizes recent research or evidence on the sleep–depression association in older adults, as well as the potential common mechanisms underlying the comorbidity of sleep and depression disorders, focusing on the clock system, neurochemical substrates, and neurocircuits. A better understanding of the pathophysiological mechanisms underlying sleep disturbance and depression can assist psychiatrists in better managing this comorbidity.


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About this article

An overview of mechanisms underlying the comorbidity of sleep and depression disorders in the elderly

Show Author's information Yuan Yao1,2, Dan Guo1,2, Fang-Lin Liu1,2, Ying Han1( )
National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing 100191, China
School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China

Abstract

Sleep disruption is common in older adults and has been linked to many negative health outcomes, including impaired cognitive, emotional, and interpersonal functioning and maladaptive metabolic changes. Sleep disturbance is the most common symptom in depressive patients, and it was formerly thought to be a major secondary manifestation of depression. Many longitudinal studies have identified insomnia as an independent risk factor for the development of emerging or recurrent depression in older adults, with bidirectional relationships between sleep quality and depression. This narrative review summarizes recent research or evidence on the sleep–depression association in older adults, as well as the potential common mechanisms underlying the comorbidity of sleep and depression disorders, focusing on the clock system, neurochemical substrates, and neurocircuits. A better understanding of the pathophysiological mechanisms underlying sleep disturbance and depression can assist psychiatrists in better managing this comorbidity.

Keywords: depression, neurocircuits, aging, sleep, clock system, neurochemical substrates

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Received: 25 December 2023
Revised: 20 March 2024
Accepted: 22 March 2024
Published: 05 March 2024
Issue date: March 2024

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