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Review Article | Open Access

Tet2-mediated responses to environmental stress

Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, South Korea
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Abstract

The ten-eleven translocation 2 (Tet2) protein, a member of the Tet family, acts as an α-ketoglutarate- and Fe2+-dependent dioxygenase that catalyzes the iterative oxidation of 5-methylcytosine. Tet2 is widely recognized for its involvement in diverse physiological and pathological processes. Herein, we focused on Tet2 changes in stress-related disease models, behavioral changes in response to mutant forms of Tet2, and potential mechanisms underlying the involvement of Tet2 in psychiatric symptoms. This information can contribute to the comprehensive understanding of the role of Tet2 in stress-related disorders and its potential as a therapeutic target.

Keywords

ten-eleven translocation 2stresspsychiatric disordersepigenetics

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Stress and Brain
Volume 3 Issue 4,
December 2023
Pages 147-158
DOI: 10.26599/SAB.2023.9060003

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Review Status: {{reviewData.commendedNum}} Commended , {{reviewData.revisionRequiredNum}} Revision Required , {{reviewData.notCommendedNum}} Not Commended Under Peer Review

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Cite this article:
Song WS, Xia M. Tet2-mediated responses to environmental stress. Stress and Brain, 2023, 3(4): 147-158. https://doi.org/10.26599/SAB.2023.9060003

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Received: 25 March 2023
Revised: 17 July 2023
Accepted: 18 August 2023
Published: 05 December 2023
© The Author(s) 2023

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attributtion-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission.