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Stress and Brain 2023, 3(4): 159-178 https://doi.org/10.26599/SAB.2023.9060002
Review Article | Open Access | Issue | Published: 05 December 2023

The Role of Stress in the Progression of Motor Neuron Disease: Mechanisms and Implications for Treatment

Show Author's Information Chenyang Lu1,  Xingshun Xu1,2,3( )
Department of Neurology, First Affiliated Hospital of Soochow University, Suzhou 215006, China
Institute of Neuroscience, Soochow University, Suzhou 215123, China
Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou 215123, Jiangsu, China
Keywords:
microglia, stress, oxidative stress, environmental factors, MND, HPA
Cite this article:
Lu C, Xu X. The Role of Stress in the Progression of Motor Neuron Disease: Mechanisms and Implications for Treatment. Stress and Brain, 2023, 3(4): 159-178. https://doi.org/10.26599/SAB.2023.9060002
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Abstract Full text About this article

Motor neuron diseases (MND) are a group of rare neurodegenerative diseases that significantly affect the survival of patients. The disease progresses rapidly, and currently, there is no cure for MND. Therefore, delays in MND progression and improvements in the patient’s quality of life have become crucial aspects of clinical work. Stress—a response to environmental or psychological changes—significantly affects body metabolism. In particular, excessive stress can harm the human body. Here, we review recent literature exploring the impact of stress on the progression of MND. This review also discusses the potential mechanisms of stress-induced MND deterioration, including activation of the hypothalamic–pituitary–adrenal axis, abnormal microglial activation, oxidative stress, and the accumulation of stress granules. The role of stress in the pathological changes of MND and the importance of stress management in the treatment of MND have been emphasized. Here, we highlight that the attention of clinicians to this crucial aspect can significantly influence the course and outcome of the disease.


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About this article

The Role of Stress in the Progression of Motor Neuron Disease: Mechanisms and Implications for Treatment

Show Author's information Chenyang Lu1, Xingshun Xu1,2,3( )
Department of Neurology, First Affiliated Hospital of Soochow University, Suzhou 215006, China
Institute of Neuroscience, Soochow University, Suzhou 215123, China
Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou 215123, Jiangsu, China

Abstract

Motor neuron diseases (MND) are a group of rare neurodegenerative diseases that significantly affect the survival of patients. The disease progresses rapidly, and currently, there is no cure for MND. Therefore, delays in MND progression and improvements in the patient’s quality of life have become crucial aspects of clinical work. Stress—a response to environmental or psychological changes—significantly affects body metabolism. In particular, excessive stress can harm the human body. Here, we review recent literature exploring the impact of stress on the progression of MND. This review also discusses the potential mechanisms of stress-induced MND deterioration, including activation of the hypothalamic–pituitary–adrenal axis, abnormal microglial activation, oxidative stress, and the accumulation of stress granules. The role of stress in the pathological changes of MND and the importance of stress management in the treatment of MND have been emphasized. Here, we highlight that the attention of clinicians to this crucial aspect can significantly influence the course and outcome of the disease.

Keywords: microglia, stress, oxidative stress, environmental factors, MND, HPA

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Received: 27 December 2022
Revised: 23 October 2023
Accepted: 26 October 2023
Published: 05 December 2023
Issue date: December 2023

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© The Author(s) 2023

Acknowledgements

We thank Songyue Chen for the comments on the content of the article, and we would like to thank all participants who participated in the study for their time and involvement.

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