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Research Article | Open Access

Acute alcohol exposure suppressed locomotor activity in mice

Ke Zhang1,§Ruo-Fan Li1,§Han Li1,§He Lin2Zhe-Ming Sun2Shu-Lu Zhan1( )
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
The Third Research Institute of Ministry of Public Security, Shanghai 200031, China

§ Ke Zhang, Ruo-Fan Li, and Han Li contributed equally to this work.

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Alcohol has many effects on brain function and human behavior, inducing anxiety and sedation, motor incoordination, vomiting, hypnosis, and ultimately unconsciousness. Motor function, in particular, is affected by acute and chronic exposure to alcohol, as several studies have shown. However, the role of the primary motor cortex (M1), a major component of sensorimotor integration, in alcohol-induced motor injury is still unclear. For mouse model of acute alcohol exposure, we intraperitoneally injected alcohol in a single high dose (3 g/kg) and observed the effects of alcohol exposure on neuronal c-Fos expression in mouse brains and behavioral changes in mice. We found significantly decreased locomotion coupled with significantly increased neuronal activation selectively in M1 24 h after injection of alcohol, but anxiety level was not affected. Our findings contribute to the understanding of the association between M1 function and alcohol and open a possible path for early intervention in the treatment of alcohol use symptoms.


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Stress and Brain
Pages 46-52
Cite this article:
Zhang K, Li R-F, Li H, et al. Acute alcohol exposure suppressed locomotor activity in mice. Stress and Brain, 2022, 2(1-2): 46-52.








Received: 02 May 2022
Revised: 04 July 2022
Accepted: 12 July 2022
Published: 28 July 2022
© The Author(s) 2022

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