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Research Article | Open Access

Repeated alcohol exposure induced dentate gyrus related spatial memory damage

Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
The Third Research Institute of Ministry of Public Security, Shanghai 200031, China

§ Bing-Qian Zhang, Tong Zhou, and Yu-Ting Jiang contributed equally to this work.

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Graphical Abstract


Alcohol is one of the most commonly abused drugs, and it impairs diverse functions of the central nervous system, such as cognition and memorization. The dentate gyrus (DG) region of the hippocampus is crucial for spatial memory coding. However, whether alcohol exposure can affect DG neuron activity and impair spatial memory has not been identified. Here, we discovered hippocampus DG as a key region of alcohol exposure damage. (1) We found repeated alcohol exposure overactivated DG neurons, while this activation was not shown in a single alcohol exposure group. (2) Mice exposed to alcohol repeatedly exhibited obvious spatial memory impairment. In summary, our findings provide convincing evidence that the excessive activation of hippocampus neurons is involved in spatial memory impairment caused by repeated alcohol exposure.


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Stress and Brain
Pages 39-45
Cite this article:
Zhang B-Q, Zhou T, Jiang Y-T, et al. Repeated alcohol exposure induced dentate gyrus related spatial memory damage. Stress and Brain, 2022, 2(1-2): 39-45.








Received: 02 May 2022
Revised: 29 June 2022
Accepted: 06 July 2022
Published: 20 July 2022
© The Author(s) 2022

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