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Alcohol is one of the most commonly abused drugs, and it impairs diverse functions of the central nervous system, such as cognition and memorization. The dentate gyrus (DG) region of the hippocampus is crucial for spatial memory coding. However, whether alcohol exposure can affect DG neuron activity and impair spatial memory has not been identified. Here, we discovered hippocampus DG as a key region of alcohol exposure damage. (1) We found repeated alcohol exposure overactivated DG neurons, while this activation was not shown in a single alcohol exposure group. (2) Mice exposed to alcohol repeatedly exhibited obvious spatial memory impairment. In summary, our findings provide convincing evidence that the excessive activation of hippocampus neurons is involved in spatial memory impairment caused by repeated alcohol exposure.


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Repeated alcohol exposure induced dentate gyrus related spatial memory damage

Show Author's information Bing-Qian Zhang1,§Tong Zhou1,§Yu-Ting Jiang1,§He Lin2Zhe-Ming Sun2( )Jin-Jun Ding1( )
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
The Third Research Institute of Ministry of Public Security, Shanghai 200031, China

§ Bing-Qian Zhang, Tong Zhou, and Yu-Ting Jiang contributed equally to this work.

Abstract

Alcohol is one of the most commonly abused drugs, and it impairs diverse functions of the central nervous system, such as cognition and memorization. The dentate gyrus (DG) region of the hippocampus is crucial for spatial memory coding. However, whether alcohol exposure can affect DG neuron activity and impair spatial memory has not been identified. Here, we discovered hippocampus DG as a key region of alcohol exposure damage. (1) We found repeated alcohol exposure overactivated DG neurons, while this activation was not shown in a single alcohol exposure group. (2) Mice exposed to alcohol repeatedly exhibited obvious spatial memory impairment. In summary, our findings provide convincing evidence that the excessive activation of hippocampus neurons is involved in spatial memory impairment caused by repeated alcohol exposure.

Keywords:

alcohol, spatial memory, hippocampus
Received: 02 May 2022 Revised: 29 June 2022 Accepted: 06 July 2022 Published: 20 July 2022 Issue date: June 2022
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Publication history
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Publication history

Received: 02 May 2022
Revised: 29 June 2022
Accepted: 06 July 2022
Published: 20 July 2022
Issue date: June 2022

Copyright

© The Author(s) 2022

Acknowledgements

We thank Ke Zhang, Ruo-Fan Li, Jie Li, and Han Li for their help during data processing. J.J.D. conceived and designed the study. B.Q.Z. and T.Z. collected the data. Y.T.J. analyzed the data. All of the authors wrote the manuscript together.

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