Journal Home > Volume 1 , Issue 1

On January 30, 2020, the World Health Organization (WHO) announced COVID-19 as the sixth public health emergency of international concern, and on March 11, 2020, the WHO declared that COVID-19 is a pandemic. To date, patients with COVID-19 are present in most countries in the world. Coronavirus disease 2019 (COVID-19) is caused by a coronavirus SARS-CoV-2. The COVID-19 virus and the 2003 severe acute respiratory syndrome (SARS) virus are approximately about 79% homologous, and their transmission modes are similar, but the transmission speed and range of COVID-19 virus far exceed those of the 2003 SARS virus, causing people to experience panic, anxiety, and depression. After the SARS epidemic, many survivors and medical workers had severe post-traumatic stress disorder (PTSD), which seriously affected their quality of life. Here, we reviewed the situations of PTSD after the SARS epidemic. The lessons and experiences of PTSD caused by SARS may help deal with the more severe occurrence of PTSD during and after the COVID-19 epidemic.


menu
Abstract
Full text
Outline
About this article

Prevention for post-traumatic stress disorder after the COVID-19 epidemic: Lessons from the SARS epidemic

Show Author's information Bin Wang1,2Zhigang Miao1Bo Wan1( )Xingshun Xu1,2,3( )
Institute of Neuroscience, Soochow University, Suzhou 215006, China
Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China
Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou 215123, China

Abstract

On January 30, 2020, the World Health Organization (WHO) announced COVID-19 as the sixth public health emergency of international concern, and on March 11, 2020, the WHO declared that COVID-19 is a pandemic. To date, patients with COVID-19 are present in most countries in the world. Coronavirus disease 2019 (COVID-19) is caused by a coronavirus SARS-CoV-2. The COVID-19 virus and the 2003 severe acute respiratory syndrome (SARS) virus are approximately about 79% homologous, and their transmission modes are similar, but the transmission speed and range of COVID-19 virus far exceed those of the 2003 SARS virus, causing people to experience panic, anxiety, and depression. After the SARS epidemic, many survivors and medical workers had severe post-traumatic stress disorder (PTSD), which seriously affected their quality of life. Here, we reviewed the situations of PTSD after the SARS epidemic. The lessons and experiences of PTSD caused by SARS may help deal with the more severe occurrence of PTSD during and after the COVID-19 epidemic.

Keywords: severe acute respiratory syndrome (SARS), coronavirus disease 2019 (COVID-19), prevention, post-traumatic stress disorder (PTSD)

References(65)

[1]
Zhu, N., Zhang, D. Y., Wang, W. L., Li, X. W., Yang, B., Song, J. D., Zhao, X., Huang, B. Y., Shi, W. F., Lu, R. J. et al. A novel coronavirus from patients with pneumonia in China, 2019. New England Journal of Medicine, 2020, 382(8): 727–733.
[2]
Wu, J. T., Leung, K., Leung, G. M. Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: A modelling study. The Lancet, 2020, 395(10225): 689–697.
[3]
Peeri, N. C., Shrestha, N., Rahman, M. S., Zaki, R., Tan, Z. Q., Bibi, S., Baghbanzadeh, M., Aghamohammadi, N., Zhang, W. Y., Haque, U. The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: What lessons have we learned? International Journal of Epidemiology, 2020, .
[4]
Gorbalenya, A. E., Baker, S. C., Baric, R. S., de Groot J. R., Drosten C., Gulyaeva, A. A., Haagmans, B. L., Lauber, C., Leontovich, A. M., Neuman, B. W., et al. The species Severe acute respiratory syndrome-related coronavirus: Classifying 2019-nCoV and Naming it SARS-CoV-2. Nature Microbiology, 2020, 5(4): 536–544.
[5]
Lu, R. J., Zhao, X., Li, J., Niu, P. H., Yang, B., Wu, H. L., Wang W. L., Song, H., Huang, B. Y., Zhu, N., et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The Lancet, 2020, 395(10224): 565–574.
[6]
Amirian, E. S. Potential fecal transmission of SARS-CoV-2: Current evidence and implications for public health. International Journal of Infectious Diseases, 2020, 95: 363–370.
[7]
Yu, I. T. S., Li, Y. G., Wong, T. W., Tam, W., Chan, A. T., Lee, J. H. W., Leung, D. Y. C., Ho, T. Evidence of airborne transmission of the severe acute respiratory syndrome virus. New England Journal of Medicine, 2004, 350(17): 1731–1739.
[8]
WHO. Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003. Available at: http://www.who.int/csr/sars/country/table2004_04_21/en/ (accessed 31 July, 2003)
[9]
Chong, M. Y., Wang, W. C., Hsieh, W. C., Lee, C. Y., Chiu, N. M., Yeh, W. C., Huang, T. L., Wen, J. K., Chen, C. L. Psychological impact of severe acute respiratory syndrome on health workers in a tertiary hospital. British Journal of Psychiatry, 2004, 185(2): 127–133.
[10]
Sim, K. The psychological impact of SARS: A matter of heart and mind. Canadian Medical Association Journal, 2004, 170(5): 811–812.
[11]
Wu, K. K., Chan, S. K., Ma, T. M. Posttraumatic stress after SARS. Emerging Infectious Diseases, 2005, 11(8): 1297–1300.
[12]
Olatunji, B. O., Cisler, J. M., Tolin, D. F. Quality of life in the anxiety disorders: A meta-analytic review. Clinical Psychology Review, 2007, 27(5): 572–581.
[13]
Nayback, A. M. Health disparities in military veterans with ptsd. Journal of Psychosocial Nursing and Mental Health Services, 2008, 46(6): 42–51.
[14]
Neria, Y., Nandi, A., Galea, S. Post-traumatic stress disorder following disasters: A systematic review. Psychological Medicine, 2008, 38(4): 467–480.
[15]
Lee, A. M., Wong, J. G., McAlonan, G. M., Cheung, V., Cheung, C., Sham, P. C., Chu, C. M., Wong, P. C., Tsang, K. W., Chua, S. E. Stress and psychological distress among SARS survivors 1 year after the outbreak. The Canadian Journal of Psychiatry, 2007, 52(4): 233–240.
[16]
Kwek, S. K., Chew, W. M., Ong, K. C., Ng, Alan W. K., Lee, LawrenceS. U., Kaw, G., Leow, MelvinK. S. Quality of life and psychological status in survivors of severe acute respiratory syndrome at 3 months postdischarge. Journal of Psychosomatic Research, 2006, 60(5): 513–519.
[17]
Sheng, B., Wing Cheng, S. K., Lau, K. K., Li, H. L., Yiu Chan, E. L. The effects of disease severity, use of corticosteroids and social factors on neuropsychiatric complaints in severe acute respiratory syndrome (SARS) patients at acute and convalescent phases. European Psychiatry, 2005, 20(3): 236–242.
[18]
Lancee, W. J., Maunder, R. G., Goldbloom, D. S. Prevalence of psychiatric disorders among Toronto hospital workers one to two years after the SARS outbreak. Psychiatric Services, 2008, 59(1): 91–95.
[19]
Styra, R., Hawryluck, L., Robinson, S., Kasapinovic, S., Fones, C., Gold, W. L. Impact on health care workers employed in high-risk areas during the Toronto SARS outbreak. Journal of Psychosomatic Research, 2008, 64(2): 177–183.
[20]
Maunder, R., Lancee, W., Balderson, K., Bennett, J., Borgundvaag, B., Evans, S., Fernandes, C., Goldbloom, D., Gupta, M., Hunter, J. et al. Long-term psychological and occupational effects of providing hospital healthcare during SARS outbreak. Emerging Infectious Diseases, 2006, 12(12): 1924–1932.
[21]
Maunder, R. The experience of the 2003 SARS outbreak as a traumatic stress among frontline healthcare workers in Toronto: Lessons learned. Philosophical Transactions of the Royal Society of London Series B: Biological Sciences, 2004, 359(1447): 1117–1125.
[22]
Phua, D. H. Coping responses of emergency physicians and nurses to the 2003 severe acute respiratory syndrome outbreak. Academic Emergency Medicine, 2005, 12(4): 322–328.
[23]
Wu, P., Fang, Y. Y., Guan, Z. Q., Fan, B., Kong, J. H., Yao, Z. L., Liu, X. H., Fuller, C. J., Susser, E., Lu, J. et al. The psychological impact of the SARS epidemic on hospital employees in China: Exposure, risk perception, and altruistic acceptance of risk. The Canadian Journal of Psychiatry, 2009, 54(5): 302–311.
[24]
McAlonan, G. M., Lee, A. M., Cheung, V., Cheung, C., Tsang, K. W., Sham, P. C., Chua, S. E., Wong, J. G. Immediate and sustained psychological impact of an emerging infectious disease outbreak on health care workers. The Canadian Journal of Psychiatry, 2007, 52(4): 241–247.
[25]
Lin, C. Y., Peng, Y. C., Wu, Y. H., Chang, J., Chan, C. H., Yang, D. Y. The psychological effect of severe acute respiratory syndrome on emergency department staff. Emergency Medicine Journal, 2007, 24(1): 12–17.
[26]
Wu, K. K., Chan, S. K., Ma, T. M. Posttraumatic stress, anxiety, and depression in survivors of severe acute respiratory syndrome (SARS). Journal of Traumatic Stress, 2005, 18(1): 39–42.
[27]
Hong, X., Currier, G. W., Zhao, X. H., Jiang, Y. N., Zhou, W., Wei, J. Posttraumatic stress disorder in convalescent severe acute respiratory syndrome patients: A 4-year follow-up study. General Hospital Psychiatry, 2009, 31(6): 546–554.
[28]
Mak, I. W. C., Chu, C. M., Pan, P. C., Yiu, M. G. C., Chan, V. L. Long-term psychiatric morbidities among SARS survivors. General Hospital Psychiatry, 2009, 31(4): 318–326.
[29]
Kessler, R. C. Posttraumatic stress disorder in the national comorbidity survey. Archives of General Psychiatry, 1995, 52(12): 1048.
[30]
Sprang, G. Vicarious stress: Patterns of disturbance and use of mental health services by those indirectly affected by the Oklahoma City bombing. Psychological Reports, 2001, 89(2): 331–338.
[31]
Yu, D. S. F., Lee, D. T. F., Woo, J., Thompson, D. R. Correlates of psychological distress in elderly patients with congestive heart failure. Journal of Psychosomatic Research, 2004, 57(6): 573–581.
[32]
Cheng, S. K. W., Wong, C. W., Tsang, J., Wong, K. C. Psychological distress and negative appraisals in survivors of severe acute respiratory syndrome (SARS). Psychological Medicine, 2004, 34(7): 1187–1195.
[33]
Liu, X. H., Kakade, M., Fuller, C. J., Fan, B., Fang, Y. Y., Kong, J. H., Guan, Z. Q., Wu, P. Depression after exposure to stressful events: Lessons learned from the severe acute respiratory syndrome epidemic. Comprehensive Psychiatry, 2012, 53(1): 15–23.
[34]
Hoven, C. W., Duarte, C. S., Lucas, C. P., Wu, P., Mandell, D. J., Goodwin, R. D., Cohen, M., Balaban, V., Woodruff, B. A., Bin, F. et al. Psychopathology among New York City public school children 6 months after September 11. Archives of General Psychiatry, 2005, 62(5): 545.
[35]
Lau, J. T., Yang, X. L., Pang, E., Tsui, H. Y., Wong, E., Wing, Y. K. SARS-related perceptions in Hong Kong. Emerging Infectious Disease, 2005, 11(3): 417–424.
[36]
Reynolds, D. L., Garay, J. R., Deamond, S. L., Moran, M. K., Gold, W., Styra, R. Understanding, compliance and psychological impact of the SARS quarantine experience. Epidemiology and Infection, 2008, 136(7): 997–1007.
[37]
Su, T., Lien, T., Yang, C., Su, Y., Wang, J., Tsai, S., Yin, J. Prevalence of psychiatric morbidity and psychological adaptation of the nurses in a structured SARS caring unit during outbreak: A prospective and periodic assessment study in Taiwan. Journal of Psychiatric Research, 2007, 41(1–2): 119–130.
[38]
North, C. S., Kawasaki, A., Spitznagel, E. L., Hong, B. A. The course of PTSD, major depression, substance abuse, and somatization after a natural disaster. The Journal of Nervous and Mental Disease, 2004, 192(12): 823–829.
[39]
Mak, I. W. C., Chu, C. M., Pan, P. C., Yiu, M. G. C., Ho, S. C., Chan, V. L. Risk factors for chronic post-traumatic stress disorder (PTSD) in SARS survivors. General Hospital Psychiatry, 2010, 32(6): 590–598.
[40]
Cheng, S. K. W., Sheng, B., Lau, K. K., Wong, C. W., Ng, Y. K., Li, H. L., Chan, E. L. Y., Tso, E. Y. K., Lam, K., Chau, T. N. et al. Adjustment outcomes in Chinese patients following one-month recovery from severe acute respiratory syndrome in Hong Kong. The Journal of Nervous and Mental Disease, 2004, 192(12): 868–871.
[41]
Brewin, C. R., Andrews, B., Valentine, J. D. Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults. Journal of Consulting and Clinical Psychology, 2000, 68(5): 748–766.
[42]
Lee, T. M. C., Chi, I., Chung, L. W. M., Chou, K. L. Ageing and psychological response during the post-SARS period. Aging & Mental Health, 2006, 10(3): 303–311.
[43]
Meaney, M. J. Epigenetics and the biological definition of gene × environment interactions. Child Development, 2010, 81(1): 41–79.
[44]
Mehta, D., Binder, E. B. Gene × environment vulnerability factors for PTSD: The HPA-axis. Neuropharmacology, 2012, 62(2): 654–662.
[45]
Costello, J. F. Methylation matters. Journal of Medical Genetics, 2001, 38(5): 285–303.
[46]
Blacker, C. J., Frye, M. A., Morava-Kozicz, E., Kozicz, T., Veldic, M. A review of epigenetics of PTSD in comorbid psychiatric conditions. Genes, 2019, 10(2): 140.
[47]
Ladd, C. O., Huot, R. L., Thrivikraman, K. V., Nemeroff, C. B., Meaney, M. J., Plotsky, P. M. Long-term behavioral and neuroendocrine adaptations to adverse early experience. In: Mayer, E. A., Saper C. B. (eds.), The Biological Basis for Mind Body Interactions. Elsevier, 2000: 81–103.
DOI
[48]
McGowan, P. O., Sasaki, A., D’Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., Meaney, M. J. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience, 2009, 12(3): 342–348.
[49]
Murgatroyd, C., Patchev, A. V., Wu, Y. H., Micale, V., Bockmühl, Y., Fischer, D., Holsboer, F., Wotjak, C. T., Almeida, O. F. X., Spengler, D. Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nature Neuroscience, 2009, 12(12): 1559–1566.
[50]
Prasad, A., Chaichi, A., Kelley, D. P., Francis, J., Gartia, M. R. Current and future functional imaging techniques for post-traumatic stress disorder. RSC Advances, 2019, 9(42): 24568–24594.
[51]
Ryan, J., Chaudieu, I., Ancelin, M. L., Saffery, R. Biological underpinnings of trauma and post-traumatic stress disorder: Focusing on genetics and epigenetics. Epigenomics, 2016, 8(11): 1553–1569.
[52]
Mehta, D., Binder, E. B. Gene × environment vulnerability factors for PTSD: The HPA-axis. Neuropharmacology, 2012, 62(2): 654–662.
[53]
Zuj, D. V., Palmer, M. A., Lommen, M. J. J., Felmingham, K. L. The centrality of fear extinction in linking risk factors to PTSD: A narrative review. Neuroscience & Biobehavioral Reviews, 2016, 69: 15–35.
[54]
Ehlers, A., Clark, D. M. A cognitive model of posttraumatic stress disorder. Behaviour Research and Therapy, 2000, 38(4): 319–345.
[55]
McNally, R. Cognitive abnormalities in post-traumatic stress disorder. Trends in Cognitive Sciences, 2006, 10(6): 271–277.
[56]
Chan, A. O. M. Psychological impact of the 2003 severe acute respiratory syndrome outbreak on health care workers in a medium size regional general hospital in Singapore. Occupational Medicine, 2004, 54(3): 190–196.
[57]
Chan, C. L. W., Chan, T. H. Y., Ng, S. M. The strength-focused and meaning-oriented approach to resilience and transformation (SMART). Social Work in Health Care, 2006, 43(2–3): 9–36.
[58]
Duan, L., Zhu, G. Psychological interventions for people affected by the COVID-19 epidemic. The Lancet Psychiatry, 2020, 7(4): 300–302.
[59]
Lima, C. K. T., de Medeiros Carvalho, P. M., de Araújo Araruna Silva Lima, I., de Oliveira Nunes, J. V. A., Saraiva, J. S., de Souza, R. I., da Silva, C. G. L., Neto, M. L. R. The emotional impact of Coronavirus 2019-nCoV (new Coronavirus disease). Psychiatry Research, 2020, 287: 112915.
[60]
Yao, H., Chen, J. H., Xu, Y. F. Patients with mental health disorders in the COVID-19 epidemic. The Lancet Psychiatry, 2020, 7(4): e21.
[61]
Wang, G. H., Zhang, Y. T., Zhao, J., Zhang, J., Jiang, F. Mitigate the effects of home confinement on children during the COVID-19 outbreak. The Lancet, 2020, 395(10228): 945–947.
[62]
Liu, N. Q., Zhang, F., Wei, C., Jia, Y. P., Shang, Z. L., Sun, L. N., Wu, L. L., Sun, Z. E., Zhou, Y. G., Wang, Y. et al. Prevalence and predictors of PTSS during COVID-19 outbreak in China hardest-hit areas: Gender differences matter. Psychiatry Research, 2020, 287: 112921.
[63]
Huang, J. Z., Han, M. F., Luo, T. D., Ren, A. K., Zhou, X. P. Mental health survey of 230 medical staff in a tertiary infectious disease hospital for COVID-19. Chinese journal of industrial hygiene and occupational diseases, 2020, 38: E001. (in Chinese)
[64]
Kang, X. F., Fang, Y. Y., Li, S. H., Liu, Y. D., Zhao, D., Feng, X. J., Wang, Y. Q., Li, P. The benefits of indirect exposure to trauma: The relationships among vicarious posttraumatic growth, social support, and resilience in ambulance personnel in China. Psychiatry Investigation, 2018, 15(5): 452–459.
[65]
Wang, S., Wang B. Y., Peng, C., Song, C. P., Zhang, H. X., Sun, D. J., Li, W. W., Zhao, Y. S., Tian, W. J., Wei, S. Z., Liu, S. Y. Awareness on SARS and public health emergencies among general publics. Chinese Journal of Epidemiology, 2006, 27(6): 503–507. (in Chinese)
Publication history
Copyright
Acknowledgements
Rights and permissions

Publication history

Received: 05 April 2020
Revised: 03 May 2020
Accepted: 12 May 2020
Published: 23 December 2020
Issue date: September 2021

Copyright

© The Author(s) 2020

Acknowledgements

This work was supported by the grants from National Key R&D Program of China (No. 2017YFE0103700), the National Natural Science Foundation of China (Nos. 81120108011 and 81771454), Shandong Provincial Natural Science Foundation (No. ZR2019ZD32), and the Priority Academic Program Development of Jiangsu Higher Education Institutions of China.

Rights and permissions

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission.

Return