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Review | Open Access

Clonal hematopoiesis: linking hematopoietic stem cell aging with age-related diseases

Ziyan Li1, Zijie Zhou1, Wanling You1, Feng Xiao1, Zhenyu Ju1( ), Zhiyang Chen1( )
Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Department of Developmental & Regenerative Medicine, College of Life Science and Technology, Jinan University, No. 601, Huangpu Avenue West, Tianhe District, Guangzhou, 510632, China
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Abstract

Hematopoietic stem cells (HSCs) are the cornerstone of the blood and immune systems, and their aging plays a crucial role in the decline of both. The aging of HSCs induces systemic inflammation, which significantly contributes to the onset of age-related diseases. Understanding how to slow down the aging of tissues and organs, particularly the hematopoietic system, and how to prevent and treat aging-associated diseases, has become an urgent scientific challenge. HSC aging, coupled with clonal hematopoiesis, is a key driver of blood system aging and multi-organ age-related diseases. This review explores the relationship between HSC aging, blood diseases, and the progression of systemic diseases. We discuss potential therapeutic strategies to intervene in HSC aging, aiming to mitigate the effects of aging on the blood system and multiple organs and aging related diseases.

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Keywords

hematopoietic stem cellsagingclonal hematopoiesisinflammationaging-related diseases

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Oral Science and Homeostatic Medicine
Volume 1 Issue 1,
June 2025
Article number: 9610016
DOI: 10.26599/OSHM.2025.9610016

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Cite this article:
Li Z, Zhou Z, You W, et al. Clonal hematopoiesis: linking hematopoietic stem cell aging with age-related diseases. Oral Science and Homeostatic Medicine, 2025, 1(1): 9610016. https://doi.org/10.26599/OSHM.2025.9610016

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Received: 06 May 2025
Revised: 07 June 2025
Accepted: 14 June 2025
Published: 26 June 2025
© The Author(s) 2025. Published by Tsinghua University Press.

This article is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the original author(s) and the source, provide a link to the license, and indicate if changes were made. See https://creativecommons.org/licenses/by/4.0/