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Review | Open Access

The role of SIRT2 in homeostatic medicine and aging intervention

Yue Li1, Longchuan Han1, Yinkun Fu1, Yingting Zhang1, Zhihui Zou1, Jing Luo1, Xinxin Tang1, Lihong Tian1, Yuheng Lu1, Ying Huang1, Ming He1,2( )
Institute for Translational Medicine on Cell Fate and Disease, Shanghai Ninth People’s Hospital, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China
Department of Pathology, the Affiliated Hospital of Youjiang Medical University for Nationalities, Key Laboratory of Molecular Pathology in Tumors of Guangxi Higher Education Institutions, Baise, 533000, China
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Abstract

Homeostasis refers to the physiological processes by which an organism maintains its internal environment within a dynamic balance through negative feedback mechanisms. Disruption or failure of homeostatic mechanisms can lead to internal imbalances, potentially resulting in disease. Aging is closely associated with homeostasis, as the aging process often involves a decline in the body’s ability to regulate homeostasis, thereby increasing disease risk and leading to a decline in physiological function. SIRT2, a NAD+-dependent deacetylase belonging to the sirtuin family, plays a significant role in regulating cellular homeostasis and age-related diseases. This review discusses the multifaceted functions of SIRT2 in homeostatic medicine and aging interventions, along with its potential applications in disease treatment and anti-aging therapies.

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Keywords

aginghomeostatic medicineSIRT2cardiovascular diseaseliver diseases

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Oral Science and Homeostatic Medicine
Volume 1 Issue 1,
June 2025
Article number: 9610009
DOI: 10.26599/OSHM.2025.9610009

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Cite this article:
Li Y, Han L, Fu Y, et al. The role of SIRT2 in homeostatic medicine and aging intervention. Oral Science and Homeostatic Medicine, 2025, 1(1): 9610009. https://doi.org/10.26599/OSHM.2025.9610009

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Received: 18 April 2025
Revised: 23 May 2025
Accepted: 28 May 2025
Published: 12 June 2025
© The Author(s) 2025. Published by Tsinghua University Press.

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