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Nano TransMed 2023, 2(1): e9130019 https://doi.org/10.26599/NTM.2023.9130019
Review Article | Open Access | Issue | Published: 05 April 2023

Nanodiamond in cancer theranostics

Show Author's Information Yang Li1,§,  Xiaoling Zhu1,2,§,  Huamiao Zhang1,  Yuting Lu1,  Tangye Zeng1,  Huiping Liu1,  Ting Li1,  Jianwei Wang1,2( ),  Longguang Tang1( )
International Institutes of Medicine, the Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu 322000, China
Department of Colorectal Surgery, the Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu 322000, China

§ Yang Li and Xiaoling Zhu contributed equally to this work.

Keywords:
biocompatibility, cancer therapy, nanodiamonds, cancer imaging, clinical translation
Cite this article:
Li Y, Zhu X, Zhang H, et al. Nanodiamond in cancer theranostics. Nano TransMed, 2023, 2(1): e9130019. https://doi.org/10.26599/NTM.2023.9130019
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Abstract Full text About this article

Nanodiamonds (NDs) are emerging as a promising platform for theranostic particles since they offer a single platform that possesses multiple important properties. These include a simple mechanism of synthesis, small size, chemical inertness, a variety of available surface functional groups, good biocompatibility, stable fluorescence, and a long fluorescence lifetime. The use of NDs to deliver anticancer drugs has been an important ND application since NDs can increase chemosensitivity, sustain drug release, and minimize drug side effects. These unique properties have stimulated the application of NDs to cancer imaging and therapy. In this review, we offer a brief introduction of ND structure and their functional properties. This is followed by a summary of recent uses of NDs for imaging purposes, including fluorescent imaging, magnetic resonance imaging (MRI), and other imaging technologies. Special concern is given to studies focusing on NDs use for anticancer drug delivery, anticancer gene delivery, photothermal and photodynamic therapies, and multifunctional combination therapy. We then discuss ND biocompatibility and toxicity in various cells and animal models. Finally, we also discuss the main problems to be solved by future research before NDs can be put to clinical use. The purpose of this review is to provide a side-by-side comparison of studies reporting ND-mediated cancer imaging therapy so that readers can assess the potential clinical applications of ND and have the background necessary to understand the clinical test results associated with ND-related therapy in animals and humans.


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About this article

Nanodiamond in cancer theranostics

Show Author's information Yang Li1,§, Xiaoling Zhu1,2,§, Huamiao Zhang1, Yuting Lu1, Tangye Zeng1, Huiping Liu1, Ting Li1, Jianwei Wang1,2( ), Longguang Tang1( )
International Institutes of Medicine, the Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu 322000, China
Department of Colorectal Surgery, the Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu 322000, China

§ Yang Li and Xiaoling Zhu contributed equally to this work.

Abstract

Nanodiamonds (NDs) are emerging as a promising platform for theranostic particles since they offer a single platform that possesses multiple important properties. These include a simple mechanism of synthesis, small size, chemical inertness, a variety of available surface functional groups, good biocompatibility, stable fluorescence, and a long fluorescence lifetime. The use of NDs to deliver anticancer drugs has been an important ND application since NDs can increase chemosensitivity, sustain drug release, and minimize drug side effects. These unique properties have stimulated the application of NDs to cancer imaging and therapy. In this review, we offer a brief introduction of ND structure and their functional properties. This is followed by a summary of recent uses of NDs for imaging purposes, including fluorescent imaging, magnetic resonance imaging (MRI), and other imaging technologies. Special concern is given to studies focusing on NDs use for anticancer drug delivery, anticancer gene delivery, photothermal and photodynamic therapies, and multifunctional combination therapy. We then discuss ND biocompatibility and toxicity in various cells and animal models. Finally, we also discuss the main problems to be solved by future research before NDs can be put to clinical use. The purpose of this review is to provide a side-by-side comparison of studies reporting ND-mediated cancer imaging therapy so that readers can assess the potential clinical applications of ND and have the background necessary to understand the clinical test results associated with ND-related therapy in animals and humans.

Keywords: biocompatibility, cancer therapy, nanodiamonds, cancer imaging, clinical translation

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Publication history

Received: 10 March 2023
Revised: 27 March 2023
Accepted: 31 March 2023
Published: 05 April 2023
Issue date: March 2023

Copyright

© The Author(s) 2023. Nano TransMed published by Tsinghua University Press.

Acknowledgements

Acknowledgements

The authors would like to acknowledge the support from the National Key R&D Program of China (No. 2021YFA0909900), the National Natural Science Foundation of China (No. 52173142), Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents, and the grants from the Startup Package of Zhejiang University.

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