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Nano TransMed 2022, 1(2–4): e9130009 https://doi.org/10.26599/NTM.2022.9130009
Review Article | Open Access | Issue | Published: 13 October 2022

Advances in the therapy of cerebral ischemia-reperfusion injury with natural product-based nanoparticles

Show Author's Information Qingchun Mu1,§,  Yuhao Xue2,§,  Yuting Lu3,  Yufei Zhang4,  Qian Cheng5,  Jinlong Wan6,  Peng Liu7,  Jingjing Liu8,  yikun Qu9,  Chunming Huang6( ),  Longguang Tang3( )
Department of Neurosurgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou 570100, China
College of Life Science, Mudanjiang Medical University, Mudanjiang 157009, China
International Institutes of Medicine, The Fourth Affiliated Hospital, Zhejiang University School of medicine, Yiwu 322000, China
Department of Physiology, Guilin Medical University, Guilin 541199, China
College of Pharmacy, Guilin Medical University, Guilin 541199, China
The People's Hospital of Gaozhou, Maoming 525200, China
Department of Clinical Medicine, Jiamusi University, Jiamusi 154007, China
Department of Basic Medicine, Jiamusi University, Jiamusi 154007, China
Department of General Surgery, First Affiliated Hospital of Jiamusi University, Jiamusi 154002, China

§ Qingchun Mu and Yuhao Xue contributed equally to this work.

Keywords:
stroke, nanoparticles, drug delivery, cerebral ischemia-reperfusion injury, natural products
Cite this article:
Mu Q, Xue Y, Lu Y, et al. Advances in the therapy of cerebral ischemia-reperfusion injury with natural product-based nanoparticles. Nano TransMed, 2022, 1(2–4): e9130009. https://doi.org/10.26599/NTM.2022.9130009
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Abstract Full text About this article

Stroke is a serious acute cerebrovascular disease attributable to disruptions in the blood supply to the brain tissue as a result of vascular obstruction or sudden rupture of blood vessels in the brain, which further result in hypoxia of the brain and reduction of necessary nutrients, apoptosis of neurons, and damage to brain tissue. The majority of stroke patients are ischemic stroke. The main clinical treatments for ischemic stroke include medical thrombolysis in the early stage of onset and surgical thrombectomy or stent implantation in the late stage of onset, all of which have their own indications, advantages, and disadvantages, and show limited clinical application. For cerebral ischemia-reperfusion injury with an extremely poor prognosis, there is currently no effective prevention and treatment method in the clinic. Therefore, timely and effective treatment is needed to treat cerebral ischemia-reperfusion injury. An increasing number of studies have shown that natural products have a good curative effect on cerebral ischemia-reperfusion injury. However, due to their low solubility, low bioavailability, and short half-life, many natural products cannot optimally exert their curative effects on cerebral ischemia-reperfusion injury. Natural products-based nanoparticles modified with specific ligands have attracted much attention because of their high-efficiency permeation through the blood–brain barrier, targeted delivery abilities, and the protection of the active components from degradation. Therefore, this review focused on the prevention and treatment of cerebral ischemia-reperfusion injury in the natural product-based nanoparticles.


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About this article

Advances in the therapy of cerebral ischemia-reperfusion injury with natural product-based nanoparticles

Show Author's information Qingchun Mu1,§, Yuhao Xue2,§, Yuting Lu3, Yufei Zhang4, Qian Cheng5, Jinlong Wan6, Peng Liu7, Jingjing Liu8, yikun Qu9, Chunming Huang6( ), Longguang Tang3( )
Department of Neurosurgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou 570100, China
College of Life Science, Mudanjiang Medical University, Mudanjiang 157009, China
International Institutes of Medicine, The Fourth Affiliated Hospital, Zhejiang University School of medicine, Yiwu 322000, China
Department of Physiology, Guilin Medical University, Guilin 541199, China
College of Pharmacy, Guilin Medical University, Guilin 541199, China
The People's Hospital of Gaozhou, Maoming 525200, China
Department of Clinical Medicine, Jiamusi University, Jiamusi 154007, China
Department of Basic Medicine, Jiamusi University, Jiamusi 154007, China
Department of General Surgery, First Affiliated Hospital of Jiamusi University, Jiamusi 154002, China

§ Qingchun Mu and Yuhao Xue contributed equally to this work.

Abstract

Stroke is a serious acute cerebrovascular disease attributable to disruptions in the blood supply to the brain tissue as a result of vascular obstruction or sudden rupture of blood vessels in the brain, which further result in hypoxia of the brain and reduction of necessary nutrients, apoptosis of neurons, and damage to brain tissue. The majority of stroke patients are ischemic stroke. The main clinical treatments for ischemic stroke include medical thrombolysis in the early stage of onset and surgical thrombectomy or stent implantation in the late stage of onset, all of which have their own indications, advantages, and disadvantages, and show limited clinical application. For cerebral ischemia-reperfusion injury with an extremely poor prognosis, there is currently no effective prevention and treatment method in the clinic. Therefore, timely and effective treatment is needed to treat cerebral ischemia-reperfusion injury. An increasing number of studies have shown that natural products have a good curative effect on cerebral ischemia-reperfusion injury. However, due to their low solubility, low bioavailability, and short half-life, many natural products cannot optimally exert their curative effects on cerebral ischemia-reperfusion injury. Natural products-based nanoparticles modified with specific ligands have attracted much attention because of their high-efficiency permeation through the blood–brain barrier, targeted delivery abilities, and the protection of the active components from degradation. Therefore, this review focused on the prevention and treatment of cerebral ischemia-reperfusion injury in the natural product-based nanoparticles.

Keywords: stroke, nanoparticles, drug delivery, cerebral ischemia-reperfusion injury, natural products

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Received: 01 July 2022
Revised: 08 August 2022
Accepted: 12 August 2022
Published: 13 October 2022
Issue date: December 2022

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© The Author(s) 2022. Nano TransMed published by Tsinghua University Press.

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The authors are grateful for grants received from Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents.

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