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Since the isolation of graphene in 2004, two-dimensional (2D) materials such as transition metal dichalcogenide (TMD) have attracted numerous interests due to their unique van der Waals structure, atomically thin body, and thickness-dependent properties. In recent years, the applications of TMD in public health have emerged due to their large surface area and high surface sensitivities, as well as their unique electrical, optical, and electrochemical properties. In this review, we focus on state-of-the-art methods to modulate the properties of 2D TMD and their applications in biosensing. Particularly, this review provides methods for designing and modulating 2D TMD via defect engineering and morphology control to achieve multi-functional surfaces for molecule capturing and sensing. Furthermore, we compare the 2D TMD-based biosensors with the traditional sensing systems, deepening our understanding of their action mechanism. Finally, we point out the challenges and opportunities of 2D TMD in this emerging area.

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Biomolecule capturing and sensing on 2D transition metal dichalcogenide canvas

Show Author's information Yichao Bai1,2Linxuan Sun1,2Qiangmin Yu1,3Yu Lei1,2( )Bilu Liu1,3( )
Institute of Materials Research, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
Guangdong Provincial Key Laboratory of Thermal Management Engineering and Materials, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
Shenzhen Geim Graphene Center, Tsinghua-Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China


Since the isolation of graphene in 2004, two-dimensional (2D) materials such as transition metal dichalcogenide (TMD) have attracted numerous interests due to their unique van der Waals structure, atomically thin body, and thickness-dependent properties. In recent years, the applications of TMD in public health have emerged due to their large surface area and high surface sensitivities, as well as their unique electrical, optical, and electrochemical properties. In this review, we focus on state-of-the-art methods to modulate the properties of 2D TMD and their applications in biosensing. Particularly, this review provides methods for designing and modulating 2D TMD via defect engineering and morphology control to achieve multi-functional surfaces for molecule capturing and sensing. Furthermore, we compare the 2D TMD-based biosensors with the traditional sensing systems, deepening our understanding of their action mechanism. Finally, we point out the challenges and opportunities of 2D TMD in this emerging area.


2D materials, transition metal dichalcogenide, property modulation, biomolecule, capturing, sensing
Received: 06 October 2022 Revised: 01 November 2022 Accepted: 04 November 2022 Published: 23 November 2022

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Publication history
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Publication history

Received: 06 October 2022
Revised: 01 November 2022
Accepted: 04 November 2022
Published: 23 November 2022


© The Author(s) 2022. Published by Tsinghua University Press.



We acknowledge the supports by the National Natural Science Foundation of China (Nos. 51991343, 51991340, and 52188101), the National Science Fund for Distinguished Young Scholars (No. 52125309), Guangdong Innovative and Entrepreneurial Research Team Program (No. 2017ZT07C341), and the Shenzhen Basic Research Project (Nos. JCYJ20190809180605522, WDZC20200819095319002, and JCYJ20200109144616617). Y.L. and Y-C.B. would also like to acknowledge the Scientific Research Start-up Funds (No. QD2021033C) at Tsinghua Shenzhen International Graduate School, and Shenzhen Basic Research Project (No. JCYJ20220530142816037).

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