Visible-light photocatalytic oxidative deprotection of oximes using a pyrene-based hydrogen-bonded organic framework coordinated with copper

This study presents an efficient photocatalytic oxidative deprotection of oximes using a pyrene-based hydrogen-bonded organic framework incorporated with copper (PFC-1@Cu) under visible light irradiation. The catalyst exhibits good functional group tolerance and affords excellent yields up to 97% for a variety of carbonyl derivatives. Gram-scale reactions validate its practical applicability, while repeated cycling tests confirm its high stability and reusability. Mechanistic investigations indicate the involvement of reactive oxygen species (ROS) in the photochemical process. This work not only expands the photocatalytic applications of HOF-based materials but also offers a sustainable and efficient strategy for carbonyl deprotection.