Scalable nanoengineered gauze with sustained natural product release: Synergistic antibacterial, anti-adhesive, and angiogenic therapy for infected wound healing

Wound management remains significant challenges, encompassing numerous risks such as infection, antibiotic resistance, tissue adhesion, ischemia, hypoxia, and inflammatory responses. These complications are particularly acute in cases of bacterial infection, where conventional treatment modalities may fail to provide adequate efficacy. To address these challenges, this study introduces phytic acid (PA)@ε-polylysine (Ply)@ curcumin (Cur)@Zn@Gauze (PPCZ@Gauze), an innovative multifunctional gauze tailored to enhance wound healing. PPCZ@Gauze is designed and prepared using biosafe materials (phytic acid, ε-polylysine, curcumin, and zinc ions) through advanced surface modification techniques. Both in vitro and in vivo experiments demonstrate remarkable antibacterial properties, reduced tissue adhesion, and accelerated wound healing capabilities of PPCZ@Gauze compared to conventional medical gauze. Notably, PPCZ@Gauze also exhibits ease of preparation, cost-effectiveness, and scalability for large-scale production. Overall, this innovative multifunctional gauze offers a promising solution for managing bacterial infection wounds, leading to enhanced therapeutic outcomes and patient care.