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Review Article | Open Access

Unveiling the cutting-edge innovations in single atom catalysts: Preparation, mechanism, performance, and applications

Ting Ying1 Xinwei Shi1 Chengqing Yi2 Jian Hu2 Dejian Li2 Rui Zhu1 ( )Yao Wang3 ( )
Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai 200092, China
Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201300, China
Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China
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Abstract

As pioneering materials, single atom catalysts (SACs) have demonstrated exceptional potential across a plethora of domains ranging from biomedicine to energy conversion, environmental preservation, and marine energy. The comprehensive review delves into the latest research advancements in the practical applications of SACs, meticulously dissecting their underlying principles, distinctive features, and versatile applications. Tailoring their operational paradigms to suit diverse application contexts, we elaborate on the operational mechanisms of SACs, accentuating their unparalleled catalytic efficacy and structural resilience. The review systematically delineates the design strategies for various SAC variations, encompassing prevalent materials alongside tactics to fortify their adaptability to environmental conditions and ensure enduring operational stability. Delving further, we scrutinized the potential domains, where SACs demonstrate breakthrough potential in biomedical targeted therapy, efficient energy electrocatalysis, and the deep degradation of pollutants by maximizing atomic utilization and controlling the coordination microenvironment. Conclusively, we deliberate on the challenges confronting SACs with regards to their catalytic prowess, proposing future trajectories and methodologies to amplify their ubiquitous deployment and further refine their efficacy in real-world applications.

Graphical Abstract

Catalysis is crucial in the field of energy conversion, especially in metal-based nanomaterials and single atom catalysts (SACs), which significantly improve catalytic efficiency, selectivity, and stability by precisely controlling atomic level structures, driving progress in sustainable energy and industrial applications.

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Nano Research
Article number: 94907528

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Cite this article:
Ying T, Shi X, Yi C, et al. Unveiling the cutting-edge innovations in single atom catalysts: Preparation, mechanism, performance, and applications. Nano Research, 2025, 18(9): 94907528. https://doi.org/10.26599/NR.2025.94907528
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Received: 11 April 2025
Revised: 27 April 2025
Accepted: 28 April 2025
Published: 29 August 2025
© The Author(s) 2025. Published by Tsinghua University Press.

This is an open access article under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0, https://creativecommons.org/licenses/by/4.0/).