Platelet-derived extracellular vesicles for endometrial regeneration towards efficient live birth

Uterine infertility is a major global issue causing substantial physical and psychological hardship for individuals struggling to conceive, while endometrium injury is one of the crucial factors causing infertility. Here, we demonstrate that platelet-derived extracellular vesicles (PEVs) have excellent regenerative ability in treating endometrial injuries, facilitating endometrium regeneration and resulting in a highly efficient live birth rate in the endometrium-injured murine model. We further investigated the underlying mechanisms by which PEVs affect the endometrium, showing their ability to promote neovascularization and suppress fibrosis. More importantly, the regenerative endometrium is more receptive to embrace the embryo, which can sustain the normal pregnancy. Our finding serves as a foundational basis for advancing the clinical translation of platelet-rich plasma (PRP) and PEVs therapies for endometrial regeneration.