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Review | Open Access

Versatile Copper-Chalcogenide-Based Nanoparticles for the Treatment of Brain Diseases

Shuyang Xie§Hualong Liu§Ke Yang§Tingting WangHao Zhang( )Zhen Li( )
Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Suzhou Medical College, Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China

§These authors contributed equally to this work.

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Abstract

Copper chalcogenide nanoparticles, particularly Cu2–xE (E = S, Se, Te; 0 ≤ x ≤ 1), have gained significant interest in recent years due to their distinct physical and chemical properties, making them highly versatile for a wide range of applications. Among these, copper selenide nanoparticles (CS NPs) have attracted special attention due to their remarkable characteristics, which can be tailored through various modification strategies, providing significant potential for the diagnosis and treatment of neurological diseases. This review summarizes emerging trends and explores future perspectives on the use of CS NPs for diagnosing and treating central nervous system diseases, including glioblastoma and neurodegenerative disorders.

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Nano Biomedicine and Engineering
Pages 91-110

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Cite this article:
Xie S, Liu H, Yang K, et al. Versatile Copper-Chalcogenide-Based Nanoparticles for the Treatment of Brain Diseases. Nano Biomedicine and Engineering, 2025, 17(1): 91-110. https://doi.org/10.26599/NBE.2025.9290117

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Received: 20 December 2024
Revised: 02 February 2025
Accepted: 10 February 2025
Published: 10 March 2025
© The Author(s) 2025.

This is an open-access article distributed under  the  terms  of  the  Creative  Commons  Attribution  4.0 International  License (CC BY) (http://creativecommons.org/licenses/by/4.0/), which  permits  unrestricted  use,  distribution,  and reproduction in any medium, provided the original author and source are credited.