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Highlights | Open Access

Nanoparticle-based siRNA Delivery System in Intestine Empowers the Obesity Management

Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
Center of Gallstone Disease, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 201200, China
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Abstract

We highlighted a poly lactic acid-co-glycolic acid (PLGA)-block-polyethylene glycol (PEG) and chitosan-based nanoparticle system to deliver sterol O-acyltransferase 2 (SOAT2) siRNAs into the small intestines of mice to effectively inhibit lipid uptake and tackle obesity. Intestinal SOAT2 can regulate fatty acid uptake and its inhibition can enhance ubiquitination-based CD36 degradation in the enterocytes. This work demonstrates a potential modulatory function of intestinal SOAT2 on lipid uptake, highlighting the therapeutic effect of targeting intestinal SOAT2 against obesity. It exhibits promising translational relevance in the siRNA therapeutics-based treatment for obesity.

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Keywords

nanotechnologynanoparticlesiRNA therapydrug delivery systemobesity

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Nano Biomedicine and Engineering
Volume 16 Issue 4,
December 2024
Pages 521-524
DOI: 10.26599/NBE.2024.9290110

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Cite this article:
Yang J. Nanoparticle-based siRNA Delivery System in Intestine Empowers the Obesity Management. Nano Biomedicine and Engineering, 2024, 16(4): 521-524. https://doi.org/10.26599/NBE.2024.9290110

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Received: 11 December 2024
Revised: 31 December 2024
Accepted: 02 January 2025
Published: 14 January 2025
© The Author(s) 2024.

This is an open-access article distributed under  the  terms  of  the  Creative  Commons  Attribution  4.0 International  License (CC BY) (http://creativecommons.org/licenses/by/4.0/), which  permits  unrestricted  use,  distribution,  and reproduction in any medium, provided the original author and source are credited.