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Review | Open Access

An Exploration into the Current Application Status and Prospects of Nanorobots in Orthopedic Diseases Based on Their Medical Functions

Qi Yang1,§Fei Yu2,§( )
Peking University Shenzhen Hospital, Shenzhen 518036, China
Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China

§These authors contribute equal to this work.

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Abstract

As a category of common clinical conditions, orthopedic diseases exhibit an increasing incidence in the aging population under the background of technological advancement. Although conventional treatment methods can alleviate the symptoms and improve the quality of life of patients with orthopedic diseases, their efficacy needs to be further enhanced. Nanorobots developed based on nanotechnology have presented important application prospects in the biomedical field. They are characterized by a small size and can be employed in nanoscale operation, which can change the management of orthopedic diseases through drug delivery, disease diagnosis, and disease treatment. They also play an important role in diseases related to hard (bones and cartilages) and soft (spinal cord, peripheral nerves, blood vessels, muscles, and ligaments) tissues in the bone movement system. In this review, the application status and prospects of nanorobots in the diagnosis and treatment of orthopedic diseases are explored based on their functional role in the medical field. Scientific attempts at the treatment of orthopedic diseases based on nanorobots may be made by strengthening the targeted differentiation of cells induced by nanorobots, repairing damaged cells from a genetic perspective, developing precise targeted delivery systems for therapeutic drugs, generating stimulation signals to improve the state of damaged cells, forming damaged tissue substitutes, and coordinating driving factors for physical therapy.

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Nano Biomedicine and Engineering
Pages 542-557

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Cite this article:
Yang Q, Yu F. An Exploration into the Current Application Status and Prospects of Nanorobots in Orthopedic Diseases Based on Their Medical Functions. Nano Biomedicine and Engineering, 2024, 16(4): 542-557. https://doi.org/10.26599/NBE.2024.9290098

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Received: 12 August 2024
Revised: 06 September 2024
Accepted: 14 September 2024
Published: 06 November 2024
© The Author(s) 2024.

This is an open-access article distributed under  the  terms  of  the  Creative  Commons  Attribution  4.0 International  License (CC BY) (http://creativecommons.org/licenses/by/4.0/), which  permits  unrestricted  use,  distribution,  and reproduction in any medium, provided the original author and source are credited.