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Review | Open Access | Online First

Emerging Application of Graphene Quantum Dots in Photodynamic/Photothermal and Hyperthermia Therapies for Cancer Treatment

Rahul S. Tade1( )Mahesh P. More2
Department of Pharmaceutics, H.R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra 425405, India
Department of Pharmaceutics, Dr. Rajendra Gode College of Pharmacy, Malkapur, Maharashtra 443101, India
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Abstract

This study explores the emerging multifunctional applications of graphene quantum dots (GQDs) in cancer treatment, specifically focusing on photodynamic/photothermal therapy (PDT/PTT) and hyperthermia therapy. GQDs are a nanoscale carbon-based material with remarkable optical and thermal properties that hold considerable promise for various biomedical applications, particularly in cancer therapy. The review also focuses on emphasizing the importance of continued research and development in GQD synthesis, functionalization, and delivery systems. With their unique properties and multifaceted nature, GQDs offer promising opportunities for advancing cancer therapeutics toward more effective and targeted treatments. We discuss current trends and discrimination of GQD-based PDT/PTT strategies, showcasing the diverse techniques and approaches employed to maximize their therapeutic benefits. Furthermore, we elaborate on the critical dilemmas in the discrimination of GQD-based PDT/PTT strategies in clinical settings. Advancements in GQD-based PDT/PTT have the potential to significantly improve treatment efficacies and reduce side effects in cancer therapy.

References

[1]

A.E. Heitz, R.N. Baumgartner, K.B. Baumgartner, et al. Healthy lifestyle impact on breast cancer-specific and all-cause mortality. Breast Cancer Research and Treatment, 2018, 167(1): 171−181. https://doi.org/10.1007/s10549-017-4467-2

[2]

P. Pal Choudhury, A.N. Wilcox, M.N. Brook, et al. Comparative validation of breast cancer risk prediction models and projections for future risk stratification. JNCI:Journal of the National Cancer Institute, 2020, 112(3): 278−285. https://doi.org/10.1093/jnci/djz113

[3]

L.J. Grimm, A. Saha, S.V. Ghate, et al. Relationship between background parenchymal enhancement on high-risk screening MRI and future breast cancer risk. Academic Radiology, 2019, 26(1): 69−75. https://doi.org/10.1016/j.acra.2018.03.013

[4]

G. Kara, G.A. Calin, B. Ozpolat. RNAi-based therapeutics and tumor targeted delivery in cancer. Advanced Drug Delivery Reviews, 2022, 182: 114113. https://doi.org/10.1016/j.addr.2022.114113

[5]

U. Hafeez, S. Parakh, H.K. Gan, et al. Antibody–drug conjugates for cancer therapy. Molecules, 2020, 25(20): 4764. https://doi.org/10.3390/molecules25204764

[6]

R. Bhole. A comprehensive review on photodynamic therapy (PDT) and photothermal therapy (PTT) for cancer treatment. Turkish Journal of Oncology, 2021, 36(1): 125−132. https://doi.org/10.5505/tjo.2020.2400

[7]

S. Mahalingam, A. Manap, A. Omar, et al. Functionalized graphene quantum dots for dye-sensitized solar cell: Key challenges, recent developments and future prospects. Renewable and Sustainable Energy Reviews, 2021, 144: 110999. https://doi.org/10.1016/j.rser.2021.110999

[8]

L.Q. Yin, J.P. Zhou, W.T. Li, et al. Yellow fluorescent graphene quantum dots as a phosphor for white tunable light-emitting diodes. RSC Advances, 2019, 9(16): 9301−9307. https://doi.org/10.1039/c8ra10353d

[9]

S.S. Mousavi, A. Kazempour, B. Efafi, et al. Effects of graphene quantum dots interlayer on performance of ZnO-based photodetectors. Applied Surface Science, 2019, 493: 1187−1194. https://doi.org/10.1016/j.apsusc.2019.07.145

[10]

R.S. Tade, P.O. Patil. Fabrication of poly-l-lysine-functionalized graphene quantum dots for the label-free fluorescent-based detection of carcinoembryonic antigen. ACS Biomaterials Science &Engineering, 2022, 8(2): 470−483. https://doi.org/10.1021/acsbiomaterials.1c01087

[11]

B. Ali Al Jahdaly, M.F. Elsadek, B.M. Ahmed, et al. Outstanding graphene quantum dots from carbon source for biomedical and corrosion inhibition applications: A review. Sustainability, 2021, 13(4): 2127. https://doi.org/10.3390/su13042127

[12]

R.Z. Zhang, Z.F. Ding. Recent advances in graphene quantum dots as bioimaging probes. Journal of Analysis and Testing, 2018, 2(1): 45−60. https://doi.org/10.1007/s41664-018-0047-7

[13]

S. Nangare, S. Patil, K. Chaudhari, et al. Graphene quantum dots incorporated UiO-66-NH 2 based fluorescent nanocomposite for highly sensitive detection of quercetin. Nano Biomedicine and Engineering, 2023, 15(1): 1−13. https://doi.org/10.26599/NBE.2023.9290005

[14]

M. Thakur, M.K. Kumawat, R. Srivastava. Multifunctional graphene quantum dots for combined photothermal and photodynamic therapy coupled with cancer cell tracking applications. RSC Advances, 2017, 7(9): 5251−5261. https://doi.org/10.1039/c6ra25976f

[15]

R.S. Tade, P.O. Patil. Theranostic prospects of graphene quantum dots in breast cancer. ACS Biomaterials Science &Engineering, 2020, 6(11): 5987−6008. https://doi.org/10.1021/acsbiomaterials.0c01045

[16]

K.J. Lagos, H.H. Buzzá, V.S. Bagnato, et al. Carbon-based materials in photodynamic and photothermal therapies applied to tumor destruction. International Journal of Molecular Sciences, 2021, 23(1): 22. https://doi.org/10.3390/ijms23010022

[17]

G. Perini, V. Palmieri, G. Friggeri, et al. Carboxylated graphene quantum dots-mediated photothermal therapy enhances drug-membrane permeability, ROS production, and the immune system recruitment on 3D glioblastoma models. Cancer Nanotechnology, 2023, 14(1): 13. https://doi.org/10.1186/s12645-023-00168-9

[18]

P. Tian, L. Tang, K.S. Teng, et al. Graphene quantum dots from chemistry to applications. Materials Today Chemistry, 2018, 10: 221−258. https://doi.org/10.1016/j.mtchem.2018.09.007

[19]

M.H. Lan, S.J. Zhao, W.M. Liu, et al. Photosensitizers for photodynamic therapy. Advanced Healthcare Materials, 2019, 8(13): 1900132. https://doi.org/10.1002/adhm.201900132

[20]

K. Barve, U. Singh, P. Yadav, et al. Carbon-based designer and programmable fluorescent quantum dots for targeted biological and biomedical applications. Materials Chemistry Frontiers, 2023, 7(9): 1781−1802. https://doi.org/10.1039/d2qm01287a

[21]

W.S. Kuo, T.S. Yeh, C.Y. Chang, et al. Amino-functionalized nitrogen-doped graphene quantum dots for efficient enhancement of two-photon-excitation photodynamic therapy: Functionalized nitrogen as a bactericidal and contrast agent. International Journal of Nanomedicine, 2020, 15: 6961−6973. https://doi.org/10.2147/ijn.s242892

[22]

A. Ghaffarkhah, E. Hosseini, M. Kamkar, et al. Applications, and prospects of graphene quantum dots: a comprehensive review. Small, 2022, 18(2): 2102683. https://doi.org/10.1002/smll.202102683

[23]

D.Y. Pan, J.C. Zhang, Z. Li, et al. Hydrothermal route for cutting graphene sheets into blue-luminescent graphene quantum dots. Advanced Materials, 2010, 22(6): 734−738. https://doi.org/10.1002/adma.200902825

[24]

R.S. Tade, S.N. Nangare, A.G. Patil, et al. Recent Advancement in Bio-precursor derived graphene quantum dots: Synthesis, Characterization and Toxicological Perspective. Nanotechnology, 2020, 31(29): 292001. https://doi.org/10.1088/1361-6528/ab803e

[25]

A. Suryawanshi, M. Biswal, D. Mhamane, et al. Large scale synthesis of graphene quantum dots (GQDs) from waste biomass and their use as an efficient and selective photoluminescence on–off–on probe for Ag+ ions. Nanoscale, 2014, 6(20): 11664−11670. https://doi.org/10.1039/c4nr02494j

[26]

L.L. Shi, B.Y. Wang, S.Y. Lu. Efficient bottom-up synthesis of graphene quantum dots at an atomically precise level. Matter, 2023, 6(3): 728−760. https://doi.org/10.1016/j.matt.2023.01.003

[27]

R.S. Tade, M.P. More, S.N. Nangare, et al. Graphene quantum dots (GQDs) nanoarchitectonics for theranostic application in lung cancer. Journal of Drug Targeting, 2022, 30(3): 269−286. https://doi.org/10.1080/1061186x.2021.1987442

[28]

N. Shaari, S.K. Kamarudin, R. Bahru. Carbon and graphene quantum dots in fuel cell application: An overview. International Journal of Energy Research, 2021, 45(2): 1396−1424. https://doi.org/10.1002/er.5889

[29]

N. Ghanbari, Z. Salehi, A. Ali Khodadadi, et al. Glucosamine-conjugated graphene quantum dots as versatile and pH-sensitive nanocarriers for enhanced delivery of curcumin targeting to breast cancer. Materials Science and Engineering:C, 2021, 121: 111809. https://doi.org/10.1016/j.msec.2020.111809

[30]

M. Pirsaheb, S. Mohammadi, A. Salimi, et al. Functionalized fluorescent carbon nanostructures for targeted imaging of cancer cells: A review. Microchimica Acta, 2019, 186(4): 231. https://doi.org/10.1007/s00604-019-3338-4

[31]

H.-Y. Fan, X.-H. Yu, K. Wang, et al. Graphene quantum dots (GQDs)-based nanomaterials for improving photodynamic therapy in cancer treatment. European Journal of Medicinal Chemistry, 2019, 182: 111620. https://doi.org/10.1016/j.ejmech.2019.111620

[32]

Y.J. Yu, L. Mei, Y.M. Shi, et al. Ag-Conjugated graphene quantum dots with blue light-enhanced singlet oxygen generation for ternary-mode highly-efficient antimicrobial therapy. Journal of Materials Chemistry B, 2020, 8(7): 1371−1382. https://doi.org/10.1039/c9tb02300c

[33]

N. Nwahara, R. Nkhahle, B.P. Ngoy, et al. Synthesis and photophysical properties of BODIPY-decorated graphene quantum dot–phthalocyanine conjugates. New Journal of Chemistry, 2018, 42(8): 6051−6061. https://doi.org/10.1039/c8nj00758f

[34]

V.L. John, Y. Nair, T.P. Vinod. Doping and surface modification of carbon quantum dots for enhanced functionalities and related applications. Particle &Particle Systems Characterization, 2021, 38(11): 2100170. https://doi.org/10.1002/ppsc.202100170

[35]

M. Kortel, B.D. Mansuriya, N. Vargas Santana, et al. Graphene quantum dots as flourishing nanomaterials for bio-imaging, therapy development, and micro-supercapacitors. Micromachines, 2020, 11(9): 866. https://doi.org/10.3390/mi11090866

[36]

Y.L. Zhao, Q. Liu, S. Shakoor, et al. Transgenerational safety of nitrogen-doped graphene quantum dots and the underlying cellular mechanism in Caenorhabditis elegans. Toxicology Research, 2015, 4(2): 270−280. https://doi.org/10.1039/c4tx00123k

[37]

Y.H. Li, H.B. Shu, X.H. Niu, et al. Electronic and optical properties of edge-functionalized graphene quantum dots and the underlying mechanism. The Journal of Physical Chemistry C, 2015, 119(44): 24950−24957. https://doi.org/10.1021/acs.jpcc.5b05935

[38]

M. Awad, N. Thomas, T.J. Barnes, et al. Nanomaterials enabling clinical translation of antimicrobial photodynamic therapy. Journal of Controlled Release, 2022, 346: 300−316. https://doi.org/10.1016/j.jconrel.2022.04.035

[39]

Y.T. Li, Y.F. Wang, H. Shang, et al. Graphene quantum dots modified upconversion nanoparticles for photodynamic therapy. International Journal of Molecular Sciences, 2022, 23(20): 12558. https://doi.org/10.3390/ijms232012558

[40]

D. Iannazzo, C. Celesti, C. Espro. Recent advances on graphene quantum dots as multifunctional nanoplatforms for cancer treatment. Biotechnology Journal, 2021, 16(2): 1900422. https://doi.org/10.1002/biot.201900422

[41]

X.X. Yao, Z.F. Tian, J.X. Liu, et al. Mesoporous silica nanoparticles capped with graphene quantum dots for potential chemo–photothermal synergistic cancer therapy. Langmuir, 2017, 33(2): 591−599. https://doi.org/10.1021/acs.langmuir.6b04189

[42]

S. Badrigilan, B. Shaabani, N. Ghareh Aghaji, et al. Graphene quantum dots-coated bismuth nanoparticles for X-ray CT imaging-guided photothermal therapy of cancer cells. Iranian Journal of Medical Physics, 2018, 15: 250. https://doi.org/10.22038/IJMP.2018.12886

[43]

H. Wang, Q.X. Mu, K. Wang, et al. Nitrogen and boron dual-doped graphene quantum dots for near-infrared second window imaging and photothermal therapy. Applied Materials Today, 2019, 14: 108−117. https://doi.org/10.1016/j.apmt.2018.11.011

[44]

L.C. Nene, M. Managa, T. Nyokong. Photo-physicochemical properties and in vitro photodynamic therapy activity of morpholine-substituted Zinc(II)-Phthalocyanines π-π stacked on biotinylated graphene quantum dots. Dyes and Pigments, 2019, 165: 488−498. https://doi.org/10.1016/j.dyepig.2019.03.002

[45]

S. Ahirwar, S. Mallick, D. Bahadur. Electrochemical method to prepare graphene quantum dots and graphene oxide quantum dots. ACS Omega, 2017, 2(11): 8343−8353. https://doi.org/10.1021/acsomega.7b01539

[46]

S. Ahirwar, S. Mallick, D. Bahadur. Photodynamic therapy using graphene quantum dot derivatives. Journal of Solid State Chemistry, 2020, 282: 121107. https://doi.org/10.1016/j.jssc.2019.121107

[47]

S.H. Zheng, Z. Jin, C.P. Han, et al. Graphene quantum dots-decorated hollow copper sulfide nanoparticles for controlled intracellular drug release and enhanced photothermal-chemotherapy. Journal of Materials Science, 2020, 55(3): 1184−1197. https://doi.org/10.1007/s10853-019-04062-x

[48]

F. Nasrollahi, B. Sana, D. Paramelle, et al. Incorporation of graphene quantum dots, iron, and doxorubicin in/on ferritin nanocages for bimodal imaging and drug delivery. Advanced Therapeutics, 2020, 3(3): 1900183. https://doi.org/10.1002/adtp.201900183

[49]

R. Prasad, N.K. Jain, A.S. Yadav, et al. Ultrahigh penetration and retention of graphene quantum dot mesoporous silica nanohybrids for image guided tumor regression. ACS Applied Bio Materials, 2021, 4(2): 1693−1703. https://doi.org/10.1021/acsabm.0c01478

[50]

J.L. Liang, J.J. Liu, X.K. Jin, et al. Versatile nanoplatform loaded with doxorubicin and graphene quantum dots/methylene blue for drug delivery and chemophotothermal/photodynamic synergetic cancer therapy. ACS Applied Bio Materials, 2020, 3(10): 7122−7132. https://doi.org/10.1021/acsabm.0c00942

[51]

S.Y. Choi, S.H. Baek, S.J. Chang, et al. Synthesis of upconversion nanoparticles conjugated with graphene oxide quantum dots and their use against cancer cell imaging and photodynamic therapy. Biosensors and Bioelectronics, 2017, 93: 267−273. https://doi.org/10.1016/j.bios.2016.08.094

[52]

S.H. Li, S.X. Zhou, Y.C. Li, et al. Exceptionally high payload of the IR780 iodide on folic acid-functionalized graphene quantum dots for targeted photothermal therapy. ACS Applied Materials &Interfaces, 2017, 9(27): 22332−22341. https://doi.org/10.1021/acsami.7b07267

[53]

S. Badrigilan, B. Shaabani, N. Gharehaghaji, et al. Iron oxide/bismuth oxide nanocomposites coated by graphene quantum dots: “Three-in-one” theranostic agents for simultaneous CT/MR imaging-guided in vitro photothermal therapy. Photodiagnosis and Photodynamic Therapy, 2019, 25: 504−514. https://doi.org/10.1016/j.pdpdt.2018.10.021

[54]

J.F. Fang, Y.Q. Liu, Y.W. Chen, et al. Graphene quantum dots-gated hollow mesoporous carbon nanoplatform for targeting drug delivery and synergistic chemo-photothermal therapy. International Journal of Nanomedicine, 2018, 13: 5991−6007. https://doi.org/10.2147/ijn.s175934

[55]

Y. Xuan, R.Y. Zhang, D.H. Zhao, et al. Ultrafast synthesis of gold nanosphere cluster coated by graphene quantum dot for active targeting PA/CT imaging and near-infrared laser/pH-triggered chemo-photothermal synergistic tumor therapy. Chemical Engineering Journal, 2019, 369: 87−99. https://doi.org/10.1016/j.cej.2019.03.035

[56]

C. Wang, Y. Chen, Z.Z. Xu, et al. Fabrication and characterization of novel cRGD modified graphene quantum dots for chemo-photothermal combination therapy. Sensors and Actuators B:Chemical, 2020, 309: 127732. https://doi.org/10.1016/j.snb.2020.127732

[57]

Y. Cao, H.F. Dong, Z. Yang, et al. Aptamer-conjugated graphene quantum dots/porphyrin derivative theranostic agent for intracellular cancer-related microRNA detection and fluorescence-guided photothermal/photodynamic synergetic therapy. ACS Applied Materials &Interfaces, 2017, 9(1): 159−166. https://doi.org/10.1021/acsami.6b13150

[58]
Z.T. Fan, S.X. Zhou, C. Garcia, et al. pH-Responsive fluorescent graphene quantum dots for fluorescence-guided cancer surgery and diagnosis. Nanoscale, 2017, 9(15): 4928–4933.
[59]

K. Kholikov, S. Ilhom, M. Sajjad, et al. Improved singlet oxygen generation and antimicrobial activity of sulphur-doped graphene quantum dots coupled with methylene blue for photodynamic therapy applications. Photodiagnosis and Photodynamic Therapy, 2018, 24: 7−14. https://doi.org/10.1016/j.pdpdt.2018.08.011

[60]

S.-Y. Sung, Y.-L. Su, W. Cheng, et al. Graphene quantum dots-mediated theranostic penetrative delivery of drug and photolytics in deep tumors by targeted biomimetic nanosponges. Nano Letters, 2019, 19(1): 69−81. https://doi.org/10.1021/acs.nanolett.8b03249

[61]

C.B. Yang, K.K. Chan, G.X. Xu, et al. Biodegradable polymer-coated multifunctional graphene quantum dots for light-triggered synergetic therapy of pancreatic cancer. ACS Applied Materials &Interfaces, 2019, 11(3): 2768−2781. https://doi.org/10.1021/acsami.8b16168

[62]

M.K. Kumawat, M. Thakur, R.B. Gurung, et al. Graphene quantum dots from Mangifera indica: Application in near-infrared bioimaging and intracellular nanothermometry. ACS Sustainable Chemistry &Engineering, 2017, 5(2): 1382−1391. https://doi.org/10.1021/acssuschemeng.6b01893

[63]

W.S. Kuo, H.H. Chen, S.Y. Chen, et al. Graphene quantum dots with nitrogen-doped content dependence for highly efficient dual-modality photodynamic antimicrobial therapy and bioimaging. Biomaterials, 2017, 120: 185−194. https://doi.org/10.1016/j.biomaterials.2016.12.022

[64]

Y.L. Su, T.W. Yu, W.H. Chiang, et al. Hierarchically targeted and penetrated delivery of drugs to tumors by size-changeable graphene quantum dot nanoaircrafts for photolytic therapy. Advanced Functional Materials, 2017, 27(23): 1700056. https://doi.org/10.1002/adfm.201700056

[65]

H.J. Liu, C.W. Li, Y. Qian, et al. Magnetic-induced graphene quantum dots for imaging-guided photothermal therapy in the second near-infrared window. Biomaterials, 2020, 232: 119700. https://doi.org/10.1016/j.biomaterials.2019.119700

[66]

C.H. Wu, X.T. Guan, J.M. Xu, et al. Highly efficient cascading synergy of cancer photo-immunotherapy enabled by engineered graphene quantum dots/photosensitizer/CpG oligonucleotides hybrid nanotheranostics. Biomaterials, 2019, 205: 106−119. https://doi.org/10.1016/j.biomaterials.2019.03.020

[67]

R.Y. Li, Z.J. Li, X.L. Sun, et al. Graphene quantum dot-rare earth upconversion nanocages with extremely high efficiency of upconversion luminescence, stability and drug loading towards controlled delivery and cancer theranostics. Chemical Engineering Journal, 2020, 382: 122992. https://doi.org/10.1016/j.cej.2019.122992

[68]

F.I. Tung, L.J. Zheng, K.T. Hou, et al. One-stop radiotherapeutic targeting of primary and distant osteosarcoma to inhibit cancer progression and metastasis using 2DG-grafted graphene quantum dots. Nanoscale, 2020, 12(16): 8809−8818. https://doi.org/10.1039/c9nr10823h

[69]

T.A. Tabish, C.J. Scotton, D.C.J. Ferguson, et al. Biocompatibility and toxicity of graphene quantum dots for potential application in photodynamic therapy. Nanomedicine, 2018, 13(15): 1923−1937. https://doi.org/10.2217/nnm-2018-0018

[70]

F.J. Wo, R.J. Xu, Y.X. Shao, et al. A multimodal system with synergistic effects of magneto-mechanical, photothermal, photodynamic and chemo therapies of cancer in graphene-quantum dot-coated hollow magnetic nanospheres. Theranostics, 2016, 6(4): 485−500. https://doi.org/10.7150/thno.13411

[71]

D. Zhang, Z.F. Zhang, Y. Wu, et al. Systematic evaluation of graphene quantum dot toxicity to male mouse sexual behaviors, reproductive and offspring health. Biomaterials, 2019, 194: 215−232. https://doi.org/10.1016/j.biomaterials.2018.12.001

[72]

S. Fasbender, L. Zimmermann, R.P. Cadeddu, et al. The low toxicity of graphene quantum dots is reflected by marginal gene expression changes of primary human hematopoietic stem cells. Scientific Reports, 2019, 9: 12028. https://doi.org/10.1038/s41598-019-48567-6

[73]

T.H. Ku, W.T. Shen, C.T. Hsieh, et al. Specific forms of graphene quantum dots induce apoptosis and cell cycle arrest in breast cancer cells. International Journal of Molecular Sciences, 2023, 24(4): 4046. https://doi.org/10.3390/ijms24044046

Nano Biomedicine and Engineering
Cite this article:
Tade RS, More MP. Emerging Application of Graphene Quantum Dots in Photodynamic/Photothermal and Hyperthermia Therapies for Cancer Treatment. Nano Biomedicine and Engineering, 2024, https://doi.org/10.26599/NBE.2024.9290083

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Received: 14 January 2023
Revised: 23 February 2024
Accepted: 11 April 2024
Published: 10 May 2024
© The Author(s) 2024.

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