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Nano Biomedicine and Engineering 2024, 16(2): 152-187 https://doi.org/10.26599/NBE.2024.9290060
Review | Open Access | Issue | Published: 05 February 2024

Advances and Prospects in Integrated Nano-oncology

Show Author's Information Jinlei Jiang1,4,  Xinyuan Cui2,  Yixin Huang1,4,  Dongmei Yan3,  Bensong Wang1,  Ziyang Yang1,4,  Mingrui Chen1,  Junhao Wang1,  Yuna Zhang1,  Guan Liu1,  Cheng Zhou1,4,  Shengsheng Cui1,4,  Jian Ni1,4,  Fuhua Yang2( ),  Daxiang Cui1,4,5( )
Institute of Nano Biomedicine and Engineering, School of Sensing Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Lianyungang Maternal and Child Health Hospital, Lianyungang 222000, China
National Engineering Research Center for Nanotechnology, Shanghai 200241, China
School of Medicine, Henan University, Kaifeng 475004, China
Keywords:
nanomaterials, nanoprobes, molecular imaging, targeted therapy, nano drug delivery system, integrated nano-oncology, nano diagnosis
Cite this article:
Jiang J, Cui X, Huang Y, et al. Advances and Prospects in Integrated Nano-oncology. Nano Biomedicine and Engineering, 2024, 16(2): 152-187. https://doi.org/10.26599/NBE.2024.9290060
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Abstract Full text About this article

In recent years, the deep integration of basic research and clinical translational research of nanotechnology and oncology has led to the emergence of a new branch, namely integrated nano-oncology. This is an emerging and important interdisciplinary field, which plays an irreplaceable role in the diagnosis, treatment, early warning, monitoring and prevention of tumors, and has become a new interdisciplinary frontier. Here main advances of integrated nano-oncology was reviewed, mainly included controlled preparation of nanomaterials, ultra-sensitive detection of tumor biomarkers, multi-functional nanoimaging probes and integrated diagnosis and treatment technology, innovative nano drugs and nano drug delivery system, DNA nanotechnology, RNA nanotechnology, nano self-assembly technology, nanosensors, intelligent nanorobots, nanotherapeutic machines. The terms, concepts, trends and challenges are also discussed with the aim of promoting the application of nanotechnology in integrated oncology and solving the scientific and key technical problems in basic and clinical translational research of cancer.


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About this article

Advances and Prospects in Integrated Nano-oncology

Show Author's information Jinlei Jiang1,4, Xinyuan Cui2, Yixin Huang1,4, Dongmei Yan3, Bensong Wang1, Ziyang Yang1,4, Mingrui Chen1, Junhao Wang1, Yuna Zhang1, Guan Liu1, Cheng Zhou1,4, Shengsheng Cui1,4, Jian Ni1,4, Fuhua Yang2( ), Daxiang Cui1,4,5( )
Institute of Nano Biomedicine and Engineering, School of Sensing Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Lianyungang Maternal and Child Health Hospital, Lianyungang 222000, China
National Engineering Research Center for Nanotechnology, Shanghai 200241, China
School of Medicine, Henan University, Kaifeng 475004, China

Abstract

In recent years, the deep integration of basic research and clinical translational research of nanotechnology and oncology has led to the emergence of a new branch, namely integrated nano-oncology. This is an emerging and important interdisciplinary field, which plays an irreplaceable role in the diagnosis, treatment, early warning, monitoring and prevention of tumors, and has become a new interdisciplinary frontier. Here main advances of integrated nano-oncology was reviewed, mainly included controlled preparation of nanomaterials, ultra-sensitive detection of tumor biomarkers, multi-functional nanoimaging probes and integrated diagnosis and treatment technology, innovative nano drugs and nano drug delivery system, DNA nanotechnology, RNA nanotechnology, nano self-assembly technology, nanosensors, intelligent nanorobots, nanotherapeutic machines. The terms, concepts, trends and challenges are also discussed with the aim of promoting the application of nanotechnology in integrated oncology and solving the scientific and key technical problems in basic and clinical translational research of cancer.

Keywords: nanomaterials, nanoprobes, molecular imaging, targeted therapy, nano drug delivery system, integrated nano-oncology, nano diagnosis

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Publication history

Received: 29 July 2023
Revised: 30 October 2023
Accepted: 24 November 2023
Published: 05 February 2024
Issue date: June 2024

Copyright

© The Author(s) 2024.

Acknowledgements

Acknowledgements

This work was financially supported by International Cooperation Project of National Natural Science Foundation of China (No. 82020108017), Innovation Group Project of National Natural Science Foundation of China (No. 81921002), the National Key Research and Development Project of China (No. 2017YFA0205301), Standard project of Shanghai Science and Technology Commission (21DZ2203200), and Instrument Project of Shanghai Science and Technology Commission (20142201300), and China Postdoctoral Science Foundation (Grant No. 2020M671130).

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