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Research Article | Open Access

The Effects of Nano Magnetic Graphene Oxide on In Vivo Maturation of Oocyte

Mitra Rahimi1Tahereh Foroutan1( )Fatemeh Eini2
Department of Animal Sciences, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
Fertility and Infertility Reseach Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
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Graphical Abstract

Abstract

Graphene oxide (GO) and Fe3O4 super paramagnetic material are good candidate for some applications such as drug delivery. It has been shown that combining Fe3O4 with graphene oxide increases the biological efficiency of GO. The use of novel assisted reproductive technologies such as gonadotropins injection has been able to help the fertility of infertile people, but the side effects of these methods and high costs are still problems. The aim of the present study was to investigate the effect of magnetic graphene oxide (MGO) on the in vivo maturation of mouse oocytes. Thirty 6–8-week old female Naval Medical Research Institute (NMRI) mice were treated with intra peritoneal (I.P) injection of MGO mixed with hormones. 12 h after I.P. injection of MGO mixed with PMSG and HCG, the number of metaphase II (MII) oocytes obtained from the left fallopian tubes was counted in each group. Also, immuno-cytochemical staining of glutathione and morphometric analysis of ovaries were studied. The results of this study showed that the simultaneous use of MGO, pregnant mare serum gonadotropin (PMSG), and human chorionic gonadotrophin (HCG) increases the number of MII oocytes and helps to increase maturation of oocytes. It could be concluded that MGO can increase the efficiency of super ovulating hormones due to increase in adsorption of serum hormones and growth factors.

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Nano Biomedicine and Engineering
Pages 354-362
Cite this article:
Rahimi M, Foroutan T, Eini F. The Effects of Nano Magnetic Graphene Oxide on In Vivo Maturation of Oocyte. Nano Biomedicine and Engineering, 2023, 15(4): 354-362. https://doi.org/10.26599/NBE.2023.9290036

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Received: 04 June 2023
Revised: 10 July 2023
Accepted: 13 August 2023
Published: 01 November 2023
© The Author(s) 2023.

This is an open-access article distributed under  the  terms  of  the  Creative  Commons  Attribution  4.0 International  License (CC BY) (http://creativecommons.org/licenses/by/4.0/), which  permits  unrestricted  use,  distribution,  and reproduction in any medium, provided the original author and source are credited.

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