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Nano Biomedicine and Engineering 2023, 15(1): 1-13 https://doi.org/10.26599/NBE.2023.9290005
Research Article | Open Access | Issue | Published: 21 April 2023

Graphene Quantum Dots Incorporated UiO-66-NH2 Based Fluorescent Nanocomposite for Highly Sensitive Detection of Quercetin

Show Author's Information Sopan Nangare1,  Sayali Patil1,  Kalyani Chaudhari1,  Zamir Khan1,  Ashwini Patil2,  Pravin Patil1( )
Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, India
Department of Microbiology, R. C. Patel Arts, Science and Commerce College, Shirpur, India
Keywords:
fluorescence, nanoprobe, metal–organic framework, sensitivity, graphene quantum dots (GQDs), quercetin, GQDs@UiO-66 NH2
Cite this article:
Nangare S, Patil S, Chaudhari K, et al. Graphene Quantum Dots Incorporated UiO-66-NH2 Based Fluorescent Nanocomposite for Highly Sensitive Detection of Quercetin. Nano Biomedicine and Engineering, 2023, 15(1): 1-13. https://doi.org/10.26599/NBE.2023.9290005
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Abstract Full text About this article

Quercetin can help with a variety of health problems. Most methods for measuring quercetin in biological fluids are characterized by low sensitivity and selectivity. The employment of metal–organic frameworks in sensor applications with carbon-based materials ushers in a new era. In this study, blue fluorescent graphene quantum dots (GQDs) embedded in a UiO-66-NH2 metal–organic framework-based nanoprobe (GQDs@UiO-66-NH2) were constructed for quercetin sensing. Initially, maize husk was used to produce blue fluorescent GQDs, whereas zirconium tetrachloride and 2-aminoterephthalic acid were used to synthesize extremely luminous UiO-66-NH2. The addition of quercetin to GQDs@UiO-66-NH2 leads to fluorescence dampening due to the adsorption potential of UiO-66-NH2. The complexation of zirconium ions with the 3-OH and 4-C＝O functionalities of quercetin resulted in fluorescence quenching. The sensor has a linear concentration range and limit of detection for quercetin of 50–500 and 2.82 ng/mL, respectively. The nanoprobe’s usefulness for quercetin detection was then validated by a selectivity investigation in the presence of interfering chemicals. Furthermore, the percentage relative standard deviations were 4.20% and 2.90%, respectively, indicating great stability and repeatability. Fluorescence “Turn-On–Off” nanoprobes provide a simple, quick, sensitive, and selective method for monitoring quercetin.


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About this article

Graphene Quantum Dots Incorporated UiO-66-NH2 Based Fluorescent Nanocomposite for Highly Sensitive Detection of Quercetin

Show Author's information Sopan Nangare1, Sayali Patil1, Kalyani Chaudhari1, Zamir Khan1, Ashwini Patil2, Pravin Patil1( )
Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, India
Department of Microbiology, R. C. Patel Arts, Science and Commerce College, Shirpur, India

Abstract

Quercetin can help with a variety of health problems. Most methods for measuring quercetin in biological fluids are characterized by low sensitivity and selectivity. The employment of metal–organic frameworks in sensor applications with carbon-based materials ushers in a new era. In this study, blue fluorescent graphene quantum dots (GQDs) embedded in a UiO-66-NH2 metal–organic framework-based nanoprobe (GQDs@UiO-66-NH2) were constructed for quercetin sensing. Initially, maize husk was used to produce blue fluorescent GQDs, whereas zirconium tetrachloride and 2-aminoterephthalic acid were used to synthesize extremely luminous UiO-66-NH2. The addition of quercetin to GQDs@UiO-66-NH2 leads to fluorescence dampening due to the adsorption potential of UiO-66-NH2. The complexation of zirconium ions with the 3-OH and 4-C＝O functionalities of quercetin resulted in fluorescence quenching. The sensor has a linear concentration range and limit of detection for quercetin of 50–500 and 2.82 ng/mL, respectively. The nanoprobe’s usefulness for quercetin detection was then validated by a selectivity investigation in the presence of interfering chemicals. Furthermore, the percentage relative standard deviations were 4.20% and 2.90%, respectively, indicating great stability and repeatability. Fluorescence “Turn-On–Off” nanoprobes provide a simple, quick, sensitive, and selective method for monitoring quercetin.

Keywords: fluorescence, nanoprobe, metal–organic framework, sensitivity, graphene quantum dots (GQDs), quercetin, GQDs@UiO-66 NH2

References(42)

[1]

K. Ishii, T. Furuta, Y. Kasuya. High-performance liquid chromatographic determination of quercetin in human plasma and urine utilizing solid-phase extraction and ultraviolet detection. Journal of Chromatography B, 2003, 794: 49−56. https://doi.org/10.1016/s1570-0232(03)00398-2
DOI Google Scholar
[2]

L. Durai, C. Y. Kong, S. Badhulika. One-step solvothermal synthesis of nanoflake-nanorod WS2 hybrid for non-enzymatic detection of uric acid and quercetin in blood serum. Materials Science and Engineering:C, 2020, 107: 110217. https://doi.org/10.1016/j.msec.2019.110217
DOI Google Scholar
[3]

X. Kan, T. Zhang, M. Zhong, et al. CD/AuNPs/MWCNTs based electrochemical sensor for quercetin dual-signal detection. Biosensors and Bioelectronics, 2016, 77: 638−643. https://doi.org/10.1016/j.bios.2015.10.033
DOI Google Scholar
[4]

X. Chen, Q. Li, S. Yu, et al. Activated silica gel based carbon paste electrodes exhibit signal enhancement for quercetin. Electrochimica Acta, 2012, 81: 106−111. https://doi.org/10.1016/j.electacta.2012.07.063
DOI Google Scholar
[5]

H. Lian, Y. Kang, S. Bi, et al. Direct determination of trace aluminum with quercetin by reversed-phase high performance liquid chromatography. Talanta, 2004, 62: 43−50. https://doi.org/10.1016/S0039-9140(03)00405-3
DOI Google Scholar
[6]

J. Wittig, M. Herderich, E. U. Graefe, et al. Identification of quercetin glucuronides in human plasma by high-performance liquid chromatography–tandem mass spectrometry. Journal of Chromatography B:Biomedical Sciences and Applications, 2001, 753: 237−243. https://doi.org/10.1016/S0378-4347(00)00549-1
DOI Google Scholar
[7]

G.R. Xu, S. Kim. Selective determination of quercetin using carbon nanotube-modified electrodes. Electroanalysis:An International Journal Devoted to Fundamental and Practical Aspects of Electroanalysis, 2006, 18: 1786−1792. https://doi.org/10.1002/elan.200603587
DOI Google Scholar
[8]

G. Chen, H. Zhang, J. Ye. Determination of rutin and quercetin in plants by capillary electrophoresis with electrochemical detection. Analytica Chimica Acta, 2000, 423: 69−76. https://doi.org/10.1016/S0003-2670(00)01099-0
DOI Google Scholar
[9]

M. Veerapandian, Y.T. Seo, K. Yun, et al. Graphene oxide functionalized with silver@silica–polyethylene glycol hybrid nanoparticles for direct electrochemical detection of quercetin. Biosensors and Bioelectronics, 2014, 58: 200−204. https://doi.org/10.1016/j.bios.2014.02.062
DOI Google Scholar
[10]

N.H. Khand, A.R. Solangi, S. Ameen, et al. A new electrochemical method for the detection of quercetin in onion, honey and green tea using Co3O4 modified GCE. Journal of Food Measurement and Characterization, 2021, 15: 3720−3730. https://doi.org/10.1007/s11694-021-00956-0
DOI Google Scholar
[11]

M. Vinitha, K. Naveen, S.M. Chen, et al. Electrochemical determination of quercetin using glassy carbon electrode modified with WS2/GdCoO3 nanocomposite. Mikrochim Acta, 2022, 189: 118. https://doi.org/10.1007/s00604-022-05219-3
DOI Google Scholar
[12]

S.N. Nangare, P.O. Patil. Affinity-based nanoarchitectured biotransducer for sensitivity enhancement of surface plasmon resonance sensors for in vitro diagnosis: A review. ACS Biomaterials Science &Engineering, 2020, 7: 2−30. https://doi.org/10.1021/acsbiomaterials.0c01203
DOI Google Scholar
[13]

S. Kadian, G. Manik. Sulfur doped graphene quantum dots as a potential sensitive fluorescent probe for the detection of quercetin. Food Chemistry, 2020, 317: 126457. https://doi.org/10.1016/j.foodchem.2020.126457
DOI Google Scholar
[14]

J.H. Jin, C. Kwon, W. Park, et al. Electrochemical characterization of a glassy carbon electrode modified with microbial succinoglycan monomers and multi-wall carbon nanotubes for the detection of quercetin in an aqueous electrolyte. Journal of Electroanalytical Chemistry, 2008, 623: 142−146. https://doi.org/10.1016/j.jelechem.2008.07.002
DOI Google Scholar
[15]

S. Nangare, S. Baviskar, A. Patil, et al. Design of “Turn-Off” fluorescent nanoprobe for highly sensitive detection of uric acid using green synthesized nitrogen-doped graphene quantum dots. Acta Chimica Slovenica, 2022, 69: 437−447. https://doi.org/10.17344/acsi.2022.7333
DOI Google Scholar
[16]

R.S. Tade, S.N. Nangare, A.G. Patil, et al. Recent advancement in bio-precursor derived graphene quantum dots: Synthesis, characterization and toxicological perspective. Nanotechnology, 2020, 31: 292001. https://doi.org/10.1088/1361-6528/ab803e
DOI Google Scholar
[17]

Y.C. Chen, W.H. Chiang, D. Kurniawan, et al. Impregnation of graphene quantum dots into a metal–organic framework to render increased electrical conductivity and activity for electrochemical sensing. ACS Applied Materials &Interfaces, 2019, 11: 35319−35326. https://doi.org/10.1021/acsami.9b11447
DOI Google Scholar
[18]
J. Pantwalawalkar, S. Chandankar, R. Tade, et al. Graphene quantum dot based ultrasensitive probe for biosensing of prostate cancer biomarkers: Current updates and future challenges. Advances in Natural Sciences: Nanoscience and Nanotechnology, 2022, 13: 013001.
DOI
[19]

C. Stefanov, C.C. Negut, L.A.D. Gugoasa, et al. Gold nanoparticle-graphene quantum dots nanozyme for the wide range and sensitive electrochemical determination of quercetin in plasma droplets. Microchimica Acta, 2020, 187: 1−10. https://doi.org/10.1007/s00604-020-04587-y
DOI Google Scholar
[20]

P. Zhao, M. Ni, Y. Xu, et al. A novel ultrasensitive electrochemical quercetin sensor based on MoS2-carbon nanotube@graphene oxide nanoribbons/HS-cyclodextrin/graphene quantum dots composite film. Sensors and Actuators B:Chemical, 2019, 299: 126997. https://doi.org/10.1016/j.snb.2019.126997
DOI Google Scholar
[21]

S.N. Nangare, P.M. Sangale, A.G. Patil, et al. Surface architectured metal organic frameworks-based biosensor for ultrasensitive detection of uric acid: Recent advancement and future perspectives. Microchemical Journal, 2021, 169: 106567. https://doi.org/10.1016/j.microc.2021.106567
DOI Google Scholar
[22]

S.N. Nangare, S.R. Patil, A.G. Patil, et al. Structural design of nanosize-metal–organic framework-based sensors for detection of organophosphorus pesticides in food and water samples: Current challenges and future prospects. Journal of Nanostructure in Chemistry, 2022, 12: 729−764. https://doi.org/10.1007/s40097-021-00449-y
DOI Google Scholar
[23]

Z.G. Khan, M.R. Patil, S.N. Nangare, et al. Surface nanoarchitectured metal–organic frameworks-based sensor for reduced glutathione sensing: A review. Journal of Nanostructure in Chemistry, 2022, 12: 1053−1074. https://doi.org/10.1007/s40097-022-00480-7
DOI Google Scholar
[24]

D. Zhang, Z. Wu, X. Zong. Metal-organic frameworks-derived zinc oxide nanopolyhedra/S, N: graphene quantum dots/polyaniline ternary nanohybrid for high-performance acetone sensing. Sensors and Actuators B:Chemical, 2019, 288: 232−242. https://doi.org/10.1016/j.snb.2019.02.093
DOI Google Scholar
[25]

S.N. Nangare, A.G. Patil, S.M. Chandankar, et al. Nanostructured metal–organic framework-based luminescent sensor for chemical sensing: Current challenges and future prospects. Journal of Nanostructure in Chemistry, 2022, 13: 197−242. https://doi.org/10.1007/s40097-022-00479-0
DOI Google Scholar
[26]

S. Xie, X. Li, L. Wang, et al. High quantum-yield carbon dots embedded metal-organic frameworks for selective and sensitive detection of dopamine. Microchemical Journal, 2021, 160: 105718. https://doi.org/10.1016/j.microc.2020.105718
DOI Google Scholar
[27]

L. Lu, M. Ma, C. Gao, et al. Metal organic framework@polysilsesequioxane core/shell-structured nanoplatform for drug delivery. Pharmaceutics, 2020, 12: 98. https://doi.org/10.3390/pharmaceutics12020098
DOI Google Scholar
[28]

S. Nangare, S. Patil, A. Patil, et al. Bovine serum albumin-derived poly-L-glutamic acid-functionalized graphene quantum dots embedded UiO-66-NH2 MOFs as a fluorescence ‘On-Off-On’ magic gate for para-aminohippuric acid sensing. Journal of Photochemistry and Photobiology A:Chemistry, 2023, 438: 114532. https://doi.org/10.1016/j.jphotochem.2022.114532
DOI Google Scholar
[29]

H. Xu, S. Zhou, L. Xiao, et al. Fabrication of a nitrogen-doped graphene quantum dot from MOF-derived porous carbon and its application for highly selective fluorescence detection of Fe3+. Journal of Materials Chemistry C, 2015, 3: 291−297. https://doi.org/10.1039/C4TC01991A
DOI Google Scholar
[30]

H. Abdolmohammad-Zadeh, F. Ahmadian. A fluorescent biosensor based on graphene quantum dots/zirconium-based metal-organic framework nanocomposite as a peroxidase mimic for cholesterol monitoring in human serum. Microchemical Journal, 2021, 164: 106001. https://doi.org/10.1016/j.microc.2021.106001
DOI Google Scholar
[31]

S. Safa, M. Khajeh, A.R. Oveisi, et al. Graphene quantum dots incorporated UiO-66-NH2 as a promising photocatalyst for degradation of long-chain oleic acid. Chemical Physics Letters, 2021, 762: 138129. https://doi.org/10.1016/j.cplett.2020.138129
DOI Google Scholar
[32]

S. Ahirwar, S. Mallick, D. Bahadur. Electrochemical method to prepare graphene quantum dots and graphene oxide quantum dots. ACS Omega, 2017, 2: 8343−8353. https://doi.org/10.1021/acsomega.7b01539
DOI Google Scholar
[33]

Y. Hao, S. Chen, Y. Zhou, et al. Recent progress in metal–organic framework (MOF) based luminescent chemodosimeters. Nanomaterials, 2019, 9: 974. https://doi.org/10.3390/nano9070974
DOI Google Scholar
[34]

P. Zheng, N. Wu. Fluorescence and sensing applications of graphene oxide and graphene quantum dots: A review. Chemistry–An Asian Journal, 2017, 12: 2343−2353. https://doi.org/10.1002/asia.201700814
DOI Google Scholar
[35]

K. Saenwong, P. Nuengmatcha, P. Sricharoen, et al. GSH-doped GQDs using citric acid rich-lime oil extract for highly selective and sensitive determination and discrimination of Fe3+ and Fe2+ in the presence of H2O2 by a fluorescence “turn-off” sensor. RSC Advances, 2018, 8: 10148−10157. https://doi.org/10.1039/C7RA13432K
DOI Google Scholar
[36]

H. Lin, C. Huang, W. Li, et al. Size dependency of nanocrystalline TiO2 on its optical property and photocatalytic reactivity exemplified by 2-chlorophenol. Applied Catalysis B:Environmental, 2006, 68: 1−11. https://doi.org/10.1016/j.apcatb.2006.07.018
DOI Google Scholar
[37]
S. Samimi, N. Maghsoudnia, R. B. Eftekhari, et al. Chapter 3—Lipid-based nanoparticles for drug delivery systems. Characterization and biology of nanomaterials for drug delivery. Elsevier, 2019: 47–76.
DOI
[38]

L.N. Dinh, L.N. Ramana, V. Agarwal, et al. Miniemulsion polymerization of styrene using carboxylated graphene quantum dots as surfactant. Polymer Chemistry, 2020, 11: 3217−3224. https://doi.org/10.1039/D0PY00404A
DOI Google Scholar
[39]

A.H. Ibrahim, W.A. El-Mehalmey, R.R. Haikal, et al. Tuning the chemical environment within the UiO-66-NH2 nanocages for charge-dependent contaminant uptake and selectivity. Inorganic Chemistry, 2019, 58: 15078−15087. https://doi.org/10.1021/acs.inorgchem.9b01611
DOI Google Scholar
[40]

K. Tabatabaeian, M. Simayee, A. Fallah-Shojaie, et al. N-doped carbon nanodots@ UiO-66-NH2 as novel nanoparticles for releasing of the bioactive drug, rosmarinic acid and fluorescence imaging. DARU Journal of Pharmaceutical Sciences, 2019, 27: 307−315. https://doi.org/10.1007/s40199-019-00276-1
DOI Google Scholar
[41]

M. Bagherzadeh, A. Bayrami, M. Amini. Enhancing forward osmosis (FO) performance of polyethersulfone/polyamide (PES/PA) thin-film composite membrane via the incorporation of GQDs@UiO-66-NH2 particles. Journal of Water Process Engineering, 2020, 33: 101107. https://doi.org/10.1016/j.jwpe.2019.101107
DOI Google Scholar
[42]

M.K. Bera, L. Behera, S. Mohapatra. A fluorescence turn-down-up detection of Cu2+ and pesticide quinalphos using carbon quantum dot integrated UiO-66-NH2. Colloids and Surfaces A:Physicochemical and Engineering Aspects, 2021, 624: 126792. https://doi.org/10.1016/j.colsurfa.2021.126792
DOI Google Scholar
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Received: 08 December 2022
Revised: 30 January 2023
Accepted: 19 February 2023
Published: 21 April 2023
Issue date: March 2023

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