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Research Article | Open Access

Effects of lateral habenula and ventral medial prefrontal cortex deep brain stimulation in rats

Peking University The Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China
Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100871, China
National Engineering Laboratory for Neuromodulation, Tsinghua University School of Aerospace Engineering, Tsinghua University, Beijing 100084, China

§ These authors contributed equally to this work.

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Abstract

Objective:

Deep brain stimulation (DBS) has promising outcomes in treatment-resistant depression (TRD). Several regions, including the subcallosal cingulate gyrus (SCG), nucleus accumbens, ventral capsule/ ventral striatum, and lateral habenula (LHb), can be targeted for TRD treatment. However, which target provides the best results remains controversial.

Methods:

We evaluated the antidepressant and antianxiety effects of DBS of the ventral medial prefrontal cortex (vmPFC) and LHb in stressed rats using the forced swimming test (FST) and open field test (OFT).

Results:

Bilateral high-frequency DBS of the vmPFC and LHb induced a significant decrease of the immobility time compared with that of controls (p < 0.05) in the FST. In the OFT, rats receiving vmPFC and LHb DBS showed no difference in the number of entries and time spent in the center area compared with those of control rats. However, vmPFC DBS provoked a significant decrease of these parameters compared with those of rats receiving LHb DBS (p < 0.05).

Conclusion:

These results suggested that vmPFC and LHb DBS had similar antidepressant effects, whereas LHb DBS was more effective in reducing anxiety-like behaviors. The results provide a reference for high-frequency DSB of SCG and LHb in TRD.

Keywords

lateral habenulaventral medial prefrontal cortexdeep brain stimulationdepression

References

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Journal of Neurorestoratology
Volume 10 Issue 1,
March 2022
Pages 43-51
DOI: 10.26599/JNR.2022.9040006

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Cite this article:
Fan T, Zhang Y, Wang Z, et al. Effects of lateral habenula and ventral medial prefrontal cortex deep brain stimulation in rats. Journal of Neurorestoratology, 2022, 10(1): 43-51. https://doi.org/10.26599/JNR.2022.9040006

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Received: 10 January 2022
Revised: 22 February 2022
Accepted: 23 February 2022
Published: 01 April 2022
© The authors 2022.

This article is published with open access at www.sciopen.com/journal/2324-2426, distributed under the terms of Creative Commons Attribution 4.0 International License (CC BY).