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Research Article | Open Access

Therapeutic effects of subthalamic nucleus deep brain stimulation on anxiety and depression in Parkinson’s disease patients

Department of Neurosurgery, The First Hospital of Hebei Medical University, Shijiazhuang 050031, Hebei, China
Department of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang, China
Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, China
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China
Beijing Key Laboratory of Neurostimulation, Beijing 100070, China
Chinese Institute for Brain Research, Beijing 102206, China
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Abstract

Objective:

This study aimed to determine the effects of subthalamic nucleus deep brain stimulation (STN-DBS) on anxiety and depression in Parkinson’s disease (PD) patients.

Methods:

The clinical data of 57 patients with PD who underwent bilateral STN-DBS between March and December 2018, were retrospectively analyzed. Patient scores on the Unified Parkinson’s Disease Rating Scale-Part III (UPDRS-Ⅲ), the Hamilton Anxiety Rating Scale (HAM-A), the Hamilton Depression Rating Scale (HAM-D), and the Parkinson’s Disease Questionnaire (PDQ-39) were evaluated.

Results:

Patient evaluations took place preoperatively and at 1, 3, and 6-month follow-ups. The average patient improvement rates for HAM-A and HAM-D scores at the 6-month follow-up were 41.7% [interquartile range (IQR) 34.9%] and 37.5% (IQR 33.4%), respectively (both p < 0.001). There were positive correlations between both the rate of improvement in HAM-A scores and the rate of improvement in PDQ-39 scores (r = 0.538, p < 0.001), and between the rate of improvement in HAM-D scores and the rate of improvement in PDQ-39 scores (r = 0.404, p = 0.002) at the 6-month follow-up. HAM-A and HAM-D scores were positively correlated with the Parkinson’s Hoehn-Yahr disease stage (r = 0.296, p = 0.025; and r = 0.380, p = 0.004, respectively).

Conclusion:

Bilateral STN-DBS can improve symptoms of anxiety and depression in PD patients.

Keywords

Parkinson’s diseasedeep brain stimulationsubthalamic nucleusanxietydepressionquality of life

References

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Journal of Neurorestoratology
Volume 10 Issue 1,
March 2022
Pages 31-42
DOI: 10.26599/JNR.2022.9040004

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Cite this article:
Zhang F, Wang F, Li C-H, et al. Therapeutic effects of subthalamic nucleus deep brain stimulation on anxiety and depression in Parkinson’s disease patients. Journal of Neurorestoratology, 2022, 10(1): 31-42. https://doi.org/10.26599/JNR.2022.9040004

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Received: 11 November 2021
Revised: 25 January 2022
Accepted: 15 February 2022
Published: 05 March 2022
© The authors 2022.

This article is published with open access at www.sciopen.com/journal/2324-2426, distributed under the terms of Creative Commons Attribution 4.0 International License (CC BY).