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Journal of Neurorestoratology 2022, 10(1): 31-42 https://doi.org/10.26599/JNR.2022.9040004
Research Article | Open Access | Issue | Published: 05 March 2022

Therapeutic effects of subthalamic nucleus deep brain stimulation on anxiety and depression in Parkinson’s disease patients

Show Author's Information Feng Zhang1,  Feng Wang2,3,  Cong-Hui Li1,  Ji-Wei Wang1,  Chun-Lei Han4,  Shi-Ying Fan4,  Shan-Quan Jing1,  Hong-Bo Jin1,  Lei Du1,  Wei Liu1,  Zi-Feng Wang1,  Ze-Yu Yin1,  Dong-Mei Gao4,  Yu-Jing Xing1,  Chen Yang1,  Jian-Guo Zhang4,  Fan-Gang Meng4,5,6,7( )
Department of Neurosurgery, The First Hospital of Hebei Medical University, Shijiazhuang 050031, Hebei, China
Department of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang, China
Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, China
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China
Beijing Key Laboratory of Neurostimulation, Beijing 100070, China
Chinese Institute for Brain Research, Beijing 102206, China
Keywords:
Parkinson’s disease, deep brain stimulation, subthalamic nucleus, anxiety, depression, quality of life
Cite this article:
Zhang F, Wang F, Li C-H, et al. Therapeutic effects of subthalamic nucleus deep brain stimulation on anxiety and depression in Parkinson’s disease patients. Journal of Neurorestoratology, 2022, 10(1): 31-42. https://doi.org/10.26599/JNR.2022.9040004
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Abstract Full text About this article
Objective:

This study aimed to determine the effects of subthalamic nucleus deep brain stimulation (STN-DBS) on anxiety and depression in Parkinson’s disease (PD) patients.

Methods:

The clinical data of 57 patients with PD who underwent bilateral STN-DBS between March and December 2018, were retrospectively analyzed. Patient scores on the Unified Parkinson’s Disease Rating Scale-Part III (UPDRS-Ⅲ), the Hamilton Anxiety Rating Scale (HAM-A), the Hamilton Depression Rating Scale (HAM-D), and the Parkinson’s Disease Questionnaire (PDQ-39) were evaluated.

Results:

Patient evaluations took place preoperatively and at 1, 3, and 6-month follow-ups. The average patient improvement rates for HAM-A and HAM-D scores at the 6-month follow-up were 41.7% [interquartile range (IQR) 34.9%] and 37.5% (IQR 33.4%), respectively (both p < 0.001). There were positive correlations between both the rate of improvement in HAM-A scores and the rate of improvement in PDQ-39 scores (r = 0.538, p < 0.001), and between the rate of improvement in HAM-D scores and the rate of improvement in PDQ-39 scores (r = 0.404, p = 0.002) at the 6-month follow-up. HAM-A and HAM-D scores were positively correlated with the Parkinson’s Hoehn-Yahr disease stage (r = 0.296, p = 0.025; and r = 0.380, p = 0.004, respectively).

Conclusion:

Bilateral STN-DBS can improve symptoms of anxiety and depression in PD patients.


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Abstract
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About this article

Therapeutic effects of subthalamic nucleus deep brain stimulation on anxiety and depression in Parkinson’s disease patients

Show Author's information Feng Zhang1, Feng Wang2,3, Cong-Hui Li1, Ji-Wei Wang1, Chun-Lei Han4, Shi-Ying Fan4, Shan-Quan Jing1, Hong-Bo Jin1, Lei Du1, Wei Liu1, Zi-Feng Wang1, Ze-Yu Yin1, Dong-Mei Gao4, Yu-Jing Xing1, Chen Yang1, Jian-Guo Zhang4, Fan-Gang Meng4,5,6,7( )
Department of Neurosurgery, The First Hospital of Hebei Medical University, Shijiazhuang 050031, Hebei, China
Department of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang, China
Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, China
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China
Beijing Key Laboratory of Neurostimulation, Beijing 100070, China
Chinese Institute for Brain Research, Beijing 102206, China

Abstract

Objective:

This study aimed to determine the effects of subthalamic nucleus deep brain stimulation (STN-DBS) on anxiety and depression in Parkinson’s disease (PD) patients.

Methods:

The clinical data of 57 patients with PD who underwent bilateral STN-DBS between March and December 2018, were retrospectively analyzed. Patient scores on the Unified Parkinson’s Disease Rating Scale-Part III (UPDRS-Ⅲ), the Hamilton Anxiety Rating Scale (HAM-A), the Hamilton Depression Rating Scale (HAM-D), and the Parkinson’s Disease Questionnaire (PDQ-39) were evaluated.

Results:

Patient evaluations took place preoperatively and at 1, 3, and 6-month follow-ups. The average patient improvement rates for HAM-A and HAM-D scores at the 6-month follow-up were 41.7% [interquartile range (IQR) 34.9%] and 37.5% (IQR 33.4%), respectively (both p < 0.001). There were positive correlations between both the rate of improvement in HAM-A scores and the rate of improvement in PDQ-39 scores (r = 0.538, p < 0.001), and between the rate of improvement in HAM-D scores and the rate of improvement in PDQ-39 scores (r = 0.404, p = 0.002) at the 6-month follow-up. HAM-A and HAM-D scores were positively correlated with the Parkinson’s Hoehn-Yahr disease stage (r = 0.296, p = 0.025; and r = 0.380, p = 0.004, respectively).

Conclusion:

Bilateral STN-DBS can improve symptoms of anxiety and depression in PD patients.

Keywords: Parkinson’s disease, deep brain stimulation, subthalamic nucleus, anxiety, depression, quality of life

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Publication history
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Acknowledgements
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Publication history

Received: 11 November 2021
Revised: 25 January 2022
Accepted: 15 February 2022
Published: 05 March 2022
Issue date: March 2022

Copyright

© The authors 2022.

Acknowledgements

We are grateful to all the patients recruited for this study. We thank the medical ethics committee of the First Hospital of Hebei Medical University and the medical ethics committee of Beijing Tiantan Hospital Affiliated to Capital Medical University for the approval of our study.

Rights and permissions

This article is published with open access at www.sciopen.com/journal/2324-2426, distributed under the terms of Creative Commons Attribution 4.0 International License (CC BY).

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