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Nanobiotechnology is an emerging field that has recently been explored for peripheral neural regeneration (PNR). Being a public-health problem, peripheral nerve injuries (PNIs) should be treated by the therapiesthat ensure swift functional recovery. The autologous nerve grafts (standard treatment for PNIs) are rarely available and also cause morbidity and neuroma formation at the harvest site, hence an alternative approach with minimum complications is required for the treatment of serious PNIs. Although nerve guidance conduits (NGCs) provide microenvironment for axonal regeneration but they are as yet imperfect solutions. Nanoparticles (e.g., metallic and metallic oxide nanoparticles) have properties which are interesting to include in biomaterials developed for peripheral nervous system regeneration including potential theranostic function. It is important to get an insight into the fundamental mechanisms of reconstruction of peripheral nerves for clinical translation of pre-clinical outcomes of the use of nanoparticles in PNR. Moreover, the combination of nanotechnological strategies is expected to provide transition from bed to bench-side and beyond to the patients, clinicians, and researchers.


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Nanoparticles in peripheral nerve regeneration: A mini review

Show Author's information Rabia Javed1( )Qiang Ao1,2
Department of Tissue Engineering, China Medical University, Shenyang 110122, Liaoning, China
Institute of Regulatory Science for Medical Device, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China

Abstract

Nanobiotechnology is an emerging field that has recently been explored for peripheral neural regeneration (PNR). Being a public-health problem, peripheral nerve injuries (PNIs) should be treated by the therapiesthat ensure swift functional recovery. The autologous nerve grafts (standard treatment for PNIs) are rarely available and also cause morbidity and neuroma formation at the harvest site, hence an alternative approach with minimum complications is required for the treatment of serious PNIs. Although nerve guidance conduits (NGCs) provide microenvironment for axonal regeneration but they are as yet imperfect solutions. Nanoparticles (e.g., metallic and metallic oxide nanoparticles) have properties which are interesting to include in biomaterials developed for peripheral nervous system regeneration including potential theranostic function. It is important to get an insight into the fundamental mechanisms of reconstruction of peripheral nerves for clinical translation of pre-clinical outcomes of the use of nanoparticles in PNR. Moreover, the combination of nanotechnological strategies is expected to provide transition from bed to bench-side and beyond to the patients, clinicians, and researchers.

Keywords:

nanotechnology, regeneration, peripheral nerves, nanoparticles, nerve guided conduits
Received: 22 September 2021 Revised: 27 November 2021 Accepted: 24 December 2021 Published: 05 March 2022 Issue date: March 2022
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Publication history
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Acknowledgements
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Publication history

Received: 22 September 2021
Revised: 27 November 2021
Accepted: 24 December 2021
Published: 05 March 2022
Issue date: March 2022

Copyright

© The authors 2022.

Acknowledgements

Rabia Javed acknowledges the International Postdoctoral Exchange Fellowship by China Medical University.

Rights and permissions

This article is published with open access at www.sciopen.com/journal/2324-2426, distributed under the terms of Creative Commons Attribution 4.0 International License (CC BY).

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