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Journal of Neurorestoratology 2021, 9(2): 83-93 https://doi.org/10.26599/JNR.2021.9040012
Review Article | Open Access | Issue | Published: 05 June 2021

Research progress on the therapeutic effect of olfactory ensheathing cell transplantation on ischemic stroke

Show Author's Information Jin Wang1,  Jianhua Zhao1( ),  Shaomin Li2
Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, Department of Neurology, First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, Henan, China
Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston 02115, Massachusetts, United States
Keywords:
ischemic stroke, olfactory ensheathing cells, cell therapy, cerebrovascular disease
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Wang J, Zhao J, Li S. Research progress on the therapeutic effect of olfactory ensheathing cell transplantation on ischemic stroke. Journal of Neurorestoratology, 2021, 9(2): 83-93. https://doi.org/10.26599/JNR.2021.9040012
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Abstract Full text About this article

Olfactory ensheathing cells (OECs) are a special type of glial cell in the olfactory system, which exhibit neuroprotective, immunomodulatory, and angiogenic effects. Although many studies have focused on the reversal of demyelination and axonal degeneration (during spinal cord injury) by OECs, few reports have focused on the ability of OECs to repair ischemic nerve injury. This article reviews the protective effects of OEC transplantation in ischemic stroke and provides a theoretical basis and new strategy for OEC transplantation in the treatment of ischemic stroke.


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About this article

Research progress on the therapeutic effect of olfactory ensheathing cell transplantation on ischemic stroke

Show Author's information Jin Wang1, Jianhua Zhao1( ), Shaomin Li2
Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, Department of Neurology, First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, Henan, China
Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston 02115, Massachusetts, United States

Abstract

Olfactory ensheathing cells (OECs) are a special type of glial cell in the olfactory system, which exhibit neuroprotective, immunomodulatory, and angiogenic effects. Although many studies have focused on the reversal of demyelination and axonal degeneration (during spinal cord injury) by OECs, few reports have focused on the ability of OECs to repair ischemic nerve injury. This article reviews the protective effects of OEC transplantation in ischemic stroke and provides a theoretical basis and new strategy for OEC transplantation in the treatment of ischemic stroke.

Keywords: ischemic stroke, olfactory ensheathing cells, cell therapy, cerebrovascular disease

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Received: 15 May 2021
Revised: 16 June 2021
Accepted: 30 June 2021
Published: 05 June 2021
Issue date: June 2021

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