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Journal of Neurorestoratology 2021, 9(2): 94-105 https://doi.org/10.26599/JNR.2021.9040008
Research Article | Open Access | Issue | Published: 05 June 2021

Olfactory ensheathing cell transplantation for chronic spinal cord injury: A long-term follow-up study

Show Author's Information Naifeng Kuang1,§,  Xiaoyu Wang1,§,  Yuexia Chen1,  Guifeng Liu1,  Fan’e Kong2,  Nan Wang2,  Rui Feng2,  Yan Wang1,  Xiaojing Du1,  Zuncheng Zheng1( )
Department of Rehabilitation, Taian City Central Hospital, Taian 271000, Shandong, China
Shandong First Medical University & Shandong Academy of Medical Science, Taian 271016, Shandong, China

§ These authors contributed equally to this work.

Keywords:
safety, chronic spinal cord injury, olfactory ensheathing cell transplantation, efficacy
Cite this article:
Kuang N, Wang X, Chen Y, et al. Olfactory ensheathing cell transplantation for chronic spinal cord injury: A long-term follow-up study. Journal of Neurorestoratology, 2021, 9(2): 94-105. https://doi.org/10.26599/JNR.2021.9040008
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Abstract Full text About this article

Spinal cord injury is a serious disabling condition. Transplantation of olfactory ensheathing cells (OECs) is one of the most promising treatments for spinal cord injury (SCI). Thirty-nine patients with chronic SCI received OEC transplantation and completed long-term follow-up, with a minimum follow-up of 7 years. We assessed sensorimotor function with the American Spinal Injury Association (ASIA) Impairment Scale (AIS) and autonomic nervous function by the International Standards to document remaining Autonomic Function after Spinal Cord Injury (ISAFSCI), and sympathetic skin responses (SSR). The scores of each group were significantly higher after OECs transplantation than before treatment. SSR latencies were shorter and response amplitudes increased after treatment. Long-term follow-up showed further improvement only in motor function and autonomic function compared with 3 months postoperatively. No complications occurred in any patient during long-term follow-up. The results indicate that the transplantation of OECs in spinal cord restored function without serious side effects.


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About this article

Olfactory ensheathing cell transplantation for chronic spinal cord injury: A long-term follow-up study

Show Author's information Naifeng Kuang1,§, Xiaoyu Wang1,§, Yuexia Chen1, Guifeng Liu1, Fan’e Kong2, Nan Wang2, Rui Feng2, Yan Wang1, Xiaojing Du1, Zuncheng Zheng1( )
Department of Rehabilitation, Taian City Central Hospital, Taian 271000, Shandong, China
Shandong First Medical University & Shandong Academy of Medical Science, Taian 271016, Shandong, China

§ These authors contributed equally to this work.

Abstract

Spinal cord injury is a serious disabling condition. Transplantation of olfactory ensheathing cells (OECs) is one of the most promising treatments for spinal cord injury (SCI). Thirty-nine patients with chronic SCI received OEC transplantation and completed long-term follow-up, with a minimum follow-up of 7 years. We assessed sensorimotor function with the American Spinal Injury Association (ASIA) Impairment Scale (AIS) and autonomic nervous function by the International Standards to document remaining Autonomic Function after Spinal Cord Injury (ISAFSCI), and sympathetic skin responses (SSR). The scores of each group were significantly higher after OECs transplantation than before treatment. SSR latencies were shorter and response amplitudes increased after treatment. Long-term follow-up showed further improvement only in motor function and autonomic function compared with 3 months postoperatively. No complications occurred in any patient during long-term follow-up. The results indicate that the transplantation of OECs in spinal cord restored function without serious side effects.

Keywords: safety, chronic spinal cord injury, olfactory ensheathing cell transplantation, efficacy

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Publication history

Received: 28 April 2021
Revised: 26 May 2021
Accepted: 16 June 2021
Published: 05 June 2021
Issue date: June 2021

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© The authors 2021

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This article is published with open access at http://jnr.tsinghuajournals.com

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