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Review Article | Open Access

Cerebral small vessel disease and cognitive impairment

Lifang Meng1,2,3, Jianhua Zhao1,2,3( ), Junli Liu1,2,3, Shaomin Li4
First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, Henan, China
Henan Key Laboratory of Neurorestoratology, Xinxiang 453100, Henan,China
Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Xinxiang 453100, Henan, China
Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston 02115, Massachusetts, United States
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Abstract

Cerebral small vessel disease (CSVD) is a pathophysiological process involving small arteries such as cerebellar arteries, arterioles, capillaries, and veinlets. Imaging features vary; they are mainly composed of recent subcortical infarcts, lacunes of presumed vascular origin, white matter hyperintensities (WMHs) of presumed vascular origin, cerebral microbleeds, enlarged perivascular spaces, and global and regional brain atrophy. CSVD is a common cause of vascular cognitive dysfunction, and in its end stage, dementia often develops. CSVD has been a major research hotspot; however, its causes are poorly understood. Neuroimaging markers of CSVD can be used as the basis for etiological analysis. This review highlights the relevance of neuroimaging markers and cognitive impairment, providing a new direction for the early recognition, treatment, and prevention of cognitive dysfunction in small cerebral angiopathy.

Keywords

cerebral small vascular diseasecognitive impairmentneuroimaging markers

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Journal of Neurorestoratology
Volume 7 Issue 4,
December 2019
Pages 184-195
DOI: 10.26599/JNR.2019.9040023
Cite this article:
Meng L, Zhao J, Liu J, et al. Cerebral small vessel disease and cognitive impairment. Journal of Neurorestoratology, 2019, 7(4): 184-195. https://doi.org/10.26599/JNR.2019.9040023

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Received: 28 July 2019
Revised: 14 August 2019
Accepted: 06 December 2019
Published: 29 November 2019
© The authors 2019

This article is published with open access at http://jnr.tsinghuajournals.com
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