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Journal of Neurorestoratology 2019, 7(1): 18-25 https://doi.org/10.26599/JNR.2019.9040005
Review Article | Open Access | Issue | Published: 22 March 2019

Muse cells and Neurorestoratology

Show Author's Information Zikuan Leng1,  Nikhit Kethidi2,  Allen J. Chang2,  Lijun Sun1,  Jingjing Zhai1,  Yiting Yang1,  Jianzhong Xu3,  Xijing He1( )
Department of Orthopaedics, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
W. M. Keck Center for Collaborative Neuroscience, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08901-8554, USA
Department of Orthopaedics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Keywords:
Neurorestoratology, Muse cells, central nervous system, regeneration, mesenchymal stromal cells (MSCs)
Cite this article:
Leng Z, Kethidi N, Chang AJ, et al. Muse cells and Neurorestoratology. Journal of Neurorestoratology, 2019, 7(1): 18-25. https://doi.org/10.26599/JNR.2019.9040005
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Abstract Full text About this article

Multilineage-differentiating stress-enduring (Muse) cells were discovered in 2010 as a subpopulation of mesenchymal stroma cells (MSCs). Muse cells can self-renew and tolerate severe culturing conditions. These cells can differentiate into three lineage cells spontaneously or in induced medium but do not form teratoma in vitro or in vivo. Central nervous system (CNS) diseases, such as intracerebral hemorrhage (ICH), cerebral infarction, and spinal cord injury are normally disastrous. Despite numerous therapy strategies, CNS diseases are difficult to recover. As a novel kind of pluripotent stem cells, Muse cells have shown great regeneration capacity in many animal models, including acute myocardial infarction, hepatectomy, and acute cerebral ischemia (ACI). After injection into injury sites, Muse cells survived, migrated, and differentiated into functional neurons with synaptic junctions to local neurons and contributed to recovery of function. Furthermore, Muse cell differentiation did not need to be induced pre-transplantation and no tumors were observed post- transplantation. The Muse cell population is promising and may lead to a revolution in regenerative medicine. This review focuses on recent advances regarding the Muse cells therapies in Neurorestoratology and discusses future perspectives in this field.


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About this article

Muse cells and Neurorestoratology

Show Author's information Zikuan Leng1, Nikhit Kethidi2, Allen J. Chang2, Lijun Sun1, Jingjing Zhai1, Yiting Yang1, Jianzhong Xu3, Xijing He1( )
Department of Orthopaedics, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
W. M. Keck Center for Collaborative Neuroscience, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08901-8554, USA
Department of Orthopaedics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

Abstract

Multilineage-differentiating stress-enduring (Muse) cells were discovered in 2010 as a subpopulation of mesenchymal stroma cells (MSCs). Muse cells can self-renew and tolerate severe culturing conditions. These cells can differentiate into three lineage cells spontaneously or in induced medium but do not form teratoma in vitro or in vivo. Central nervous system (CNS) diseases, such as intracerebral hemorrhage (ICH), cerebral infarction, and spinal cord injury are normally disastrous. Despite numerous therapy strategies, CNS diseases are difficult to recover. As a novel kind of pluripotent stem cells, Muse cells have shown great regeneration capacity in many animal models, including acute myocardial infarction, hepatectomy, and acute cerebral ischemia (ACI). After injection into injury sites, Muse cells survived, migrated, and differentiated into functional neurons with synaptic junctions to local neurons and contributed to recovery of function. Furthermore, Muse cell differentiation did not need to be induced pre-transplantation and no tumors were observed post- transplantation. The Muse cell population is promising and may lead to a revolution in regenerative medicine. This review focuses on recent advances regarding the Muse cells therapies in Neurorestoratology and discusses future perspectives in this field.

Keywords: Neurorestoratology, Muse cells, central nervous system, regeneration, mesenchymal stromal cells (MSCs)

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Publication history
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Publication history

Received: 11 December 2018
Revised: 24 January 2019
Accepted: 28 January 2019
Published: 22 March 2019
Issue date: March 2019

Copyright

© The authors 2019

Acknowledgements

This paper was funded by China Scholarship Council (CSC No. 201506280109) and Natural Science Foundation of China (No. 81771349).

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This article is published with open access at http://jnr.tsinghuajournals.com

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