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Research Article | Open Access

Differential effects of zinc and tellurium on epigenetic changes of coping behaviour in maturing rats

Laboratorio de Neuropsicofarmacología Experimental, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina
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Abstract

Trace element and its probable role in biological systems have attracted the attention of many researchers in recent years. Previous work has shown that ZnTe administered in drinking water to pregnant rats during pregnancy, delivery, lactation and offspring maturation up to prepuberal stage is able to modify several parameters of spontaneous behaviours related to cognition in offspring rats. Since Zn and Te have many biological properties, it’s not possible to conclude if behavioural changes are due to Zn, Te or both trace elements activity. In the present work, K2TeO3 and ZnCl2 were used alone in order to evaluate single actions of trace elements. Four experimental groups were formed: Control (water), Zn-treated group, Te-treated groups, and Zn+Te group. At the end of the experiments at 30 days of age offspring of each group were tested individually in a Double-Hole Board Labyrinth to evaluate lateralized exploration. Open field enriched with a rack and hole-board to evaluate motivated exploration; single cage in an intruder-host test to evaluate social interaction, and forced swimming cylinder to evaluate the survival responses. Results showed selective changes in rearing for Te (first Test); blocking of the natural left-biased exploration (second Test) increased time to confront the intruder with decreased time to interact with the intruder (third Test), and decreased time to active swimming (fourth Test).

With the exception of duration of the social interaction, Zn has no effect. Results suggest that most of the behavioural changes found with ZnTe in previous studies are due to Te.

References

[1]
SH Li, TF Xiao, BS Zheng. Medical geology of arsenic, selenium and thalium in China. Sci Total Environ. 2012, 421–422: 31-40.
[2]
E Steinnes. Soils and geomedicine. Environ Geochem Health. 2009, 31(5): 523-535.
[3]
C Ekmekcioglu. The role of trace elements for the health of elderly individuals. Mol Nutr Food Res. 2001, 45(5): 309-316.
[4]
H El Refaey, HS Al Amri, AE Ashour, et al. Administration of zinc with paroxetine improved the forced swim test behavioral pattern of treated mice in acute and sub-acute study. J Behav Brain Sci. 2015, 5: 213-220.
[5]
AS Prasad, JT Fitzgerald, JW Hess, et al. Zinc deficiency in elderly patients. Nutrition. 1993, 9(3): 218-224.
[6]
A Takeda. Zinc homeostasis and functions of zinc in the brain. Biometals. 2001, 14(3–4): 343-351.
[7]
RL Cunha, IE Gouvea, L Juliano,. A glimpse on biological activities of tellurium compounds. Annais da Academia Brasileira de Ciȇncias. 2009, 81(3): 393-407.
[8]
RH De Meio, FC Henriques. Tellurium IV. excretion and distribution in tissues studied with a radioactive isotope. J Biol Chem. 1947, 169: 609-623.
[9]
TG Chasteen, R Bentley. Biomethylation of selenium and tellurium: Microorganisms and plants. Chem Rev. 2003, 103(1): 1-26.
[10]
HA Schoeder, J Buckman, JJ Balassa. Abnormal trace elements in man: Tellurium. J Chron Dis. 1967, 20(3): 147-161.
[11]
ZH Siddick, RA Newman. Use of platinum as a modifier in the sensitive detection of tellurium in biological samples. Analytical Biochem. 1988, 172(1): 190-196.
[12]
RA Newman, S Osborn, ZH Siddick. Determination of tellurium in biological fluids by means of electrothermal vaporization-inductively coupled to plasma mass spectrometry (ETV-ICP-MS). Clin Chim Acta. 1989, 179(2): 191-196.
[13]
JO Boles, L Lebioda, RB Dunlap, et al. Telluromethionine in structural biochemistry. SAAS Bul Biochem Biotechno. 1995, 8: 29-34.
[14]
N Budisa, B Steipe, P Demange, et al. High level biosynthetic substitution of methionine in proteins by its analogues 2-aminohexanoic acid, selenomethionine, telluromethionine and ethionine in Escherichia coli. Eur J Biochem. 1995, 230(2): 788-796.
[15]
LY Yu, KM He, DR Chai, et al. Evidence for telluroaminoacid in biological materials and some rules for assimilation of inorganic tellurium by yeast. Ann Biochem. 1993, 209(2): 318-322.
[16]
SE Ramadan, AA Razak, AM Ragab, et al. Incorporation of tellurium into amino acids and proteins in a tellurium- tolerant fungi. Biol Trace Elem Res. 1989, 20: 225-232.
[17]
B Sredni, R Gal, IJ Cohen, et al. Hair growth induction by the Tellurium immunomodulator AS101: Association with delayed terminal differentiation of follicular keratinocytes and ras-dependent up-regulation of KGF expression. The FASEB J. 2004, 18(2): 400-402.
[18]
B Sredni, R Geffen-Aricha, W Duan, et al. Multifunctional tellurium molecule protects and restores dopaminergic neurons in Parkinson’s disease models. FASEB J. 2007, 21(8): 1870-1883.
[19]
J Anastassopoulou. Metal-DNA interactions. J Mol Struct. 2003, 651–653: 19-26.
[20]
HB Chen, QD Ke, T Kluz, et al. Nichel ions increase histone H3 lysine 9 dimethylation and induce trasgene silencing. Mol Cell Biol. 2006, 26(10): 3728-3737.
[21]
SG Ratti, M Cioccale, C Carignano, EO Alvarez. Bioinorganic chemistry of trace elements: Possible role in the epigenetic modulation of homeostatic processes in complex organisms. Am J Neuroprotec Neuroregen. 2013, 5(1): 17-24.
[22]
SG Ratti, NM Vizioli, E Gaglio, et al. Biological effects of trace elements on lateralized exploratory activity, defensive behaviour, and epigenetic DNA molecular changes in maturing rats. Am Neuroprotec Neuroregen. 2012, 4(2): 167-175.
[23]
M Szyf. The implications of DNA methylation for toxicology: Toward toxicomethylomics, the toxicology of DNA methylation. Toxicol Sci. 2011, 120(2): 235-255.
[24]
DC Dolinoy, RL Jirtle. Environmental epigenomics in human health and disease. Environmental Molecular Mutagen. 2008, 49(1): 4-8.
[25]
P Cordero, FI Milagro-Yoldi, J J. Campión-Zabalza, et al. Epigenética nutricional: Una pieza clave en el rompecabezas de la obesidad. Revista Española de Obesidad. 2010, 8(1): 10-20.
[26]
JL Fernández-Turiel, AM López-Soler, JF Llorens, et al. Environmental monitoring using surface water, river sediments, and vegetation: A case study in the Famatina range, La Rioja, NW Argentina. Environ Int. 1995, 21(6): 807-820.
[27]
SG Ratti, P Cordoba, S Rearte, et al. Differential expression of handedness, scalp hair-whorl direction, and cognitive abilities in primary school children. Int J Neuroprot Neuroregen. 2007, 4(1): 52-60.
[28]
C Francks, S Maegawa, EZ McAuley, et al. A novel imprinted locus on chromosome 2p12 associated with relative hand skill in humans. XIIth World Congress of Psychiatric Genetics. 2004, 130B(1): 14.
[29]
SG Ratti, NM Vizioli, EO Alvarez. Epigenetic modulation expressed as methylation changes in DNA from primary school children of two different geographical environments II. Am J Neuroprotec Neuroregen. 2010, 2(1): 65-70.
[30]
SG Ratti, EO Alvarez. The behavioural responses displayed by litter rats after chronic administration of non-toxic concentrations of ZnTe to parent rats are mediated primarily by Te. Am J Neuroprotec Neuroregen. 2014, 6(1): 33-42.
[31]
VA Abrego, SG Ratti, EO Alvarez. Motivated lateralized behaviour in the rat: role of the ventral hippocampus. Am J Neuroprotec Neuroregen. 2013, 5(1): 92-100.
[32]
WJ Conover. Practical nonparametric statistics (3rd edition). Wiley Series in Probability and Statistics. John Wiley & Sons, New York, 1999.
[33]
EO Alvarez. Conceptos estadísticos para las ciencias de la salud. Editorial Universitaria Universidad Católica de Cuyo. San Luis, Argentina, 2017.
[34]
NIH Research Council. Guide for the care and use of laboratory animals (8th edition). Washington, D. C.: The National Academies Press, 2011:123-131.
[35]
CJ Foltz, DVM. Ullman-Cullere Guidelines for assessing the health and condition of mice. Lab Anim. 1999, 28(4): 28-32.
[36]
U Zabel, R Schreck, PA Baeuerle. DNA binding of purified transcription factor NF-κB. J BiolChem. 1991, 266: 252-260.
[37]
AV Kudrin. Trace elements in regulation of NF-κB activity. J Trace Elem Med Bio. 2000, 14(3): 129-142.
[38]
F Okumura, Y Li, N Itoh, et al. The zinc-sensing transcription factor MTF-1 mediates zinc-induced epigenetic changes in chromatin of the mouse metallothionein-l promoter. Biochim Biophys Acta. 2011, 1809(1): 56-62.
[39]
EO Alvarez, AM Banzan. Neurochemistry of exploratory behaviour in the rat: Role of histamine and glutamic acid neuronal circuits. Int J Neuroprot Neuroregen. 2008, 4(2): 130-144.
[40]
EO Alvarez and PA Alvarez. Motivated exploratory behaviour in the rat: the role of hippocampus and the histaminergic neurotransmission. Behav Brain Res. 2008, 186(1): 118-125.
[41]
SG Ratti, AB Orozco, EO Alvarez. Lateralized exploratory behaviour, and exploration motivated by novelty after localized microinjections of ZnTe into the basolateral amygdala in the rat. Am J Neuroprotec Neuroregen. 2016, 8(1): 79-85.
[42]
B Sredni. Immunomodulating tellurium compounds as anti- cancer agents. Semin Cancer Biol. 2012, 22(1): 60-69.
[43]
TG Chasteen, DE Fuentes, JC Tantaleán, et al. Tellurite: History, oxidative stress, and molecular mechanisms of resistance. FEMS Microbiol Rev. 2009, 33(4): 820-832.
[44]
M Wagner-Recio, AD Toews, P Morell. Tellurium blocks cholesterol synthesis by inhibiting squalene metabolism: Preferential vulnerability to this metabolic block leads to peripheral nervous system demyelination. J Neurochem. 1991, 57(6): 1891-1901.
[45]
AD Toews, EB Roe, JF Goodrum, et al. Tellurium causes dose-dependent coordinate down-regulation of myolin gene expression. Mol Brain Res. 1997, 49(1–2): 113-119.
[46]
M Wagner, AD Toews, P Morell. Tellurite specifically affects squalene epoxidase: Investigations examining the mechanism of tellurium-induced neuropathy. J Neurochem. 1995, 64(5): 2169-2176.
[47]
S Roy, D Hardej. Tellurium tetrachloride and diphenyl ditelluride cause cytotoxicity in rat hippocampal astrocytes. Food Chem Toxicol. 2011, 49(10): 2564-2574.
[48]
M Smialek, B Gajkowska, D Otrebska. Electron microscopy studies on the neurotoxic effect of sodium tellurite in the central nervous system of the adult rat. J Brain Res. 1994, 35(2): 223-232.
[49]
E Widy-Tyszkiewicz, A Piechal, B Gajkowska, et al. Tellurium-induced cognitive deficits in rats are related to neuropathological changes in the central nervous system. Toxicol Lett. 2002, 131(3): 203-214.
[50]
AM Favero, SN Weis, EC Stangherlin, et al. Sub-chronic exposure of adult male rats to diphenyl ditelluride did not aaffect the development of their progeny. Food Chem Toxicol. 2007, 45(5): 859-862.
[51]
EC Stanghlerlin, AM Favero, G Zeni, et al. Exposure of mothers to diphenyl ditelluride during the suckling period changes behavioral tendencies in their offspring. Brain Res Bull. 2006, 69(3): 311-317.
[52]
KS Crider, TP Yang, RJ Berry, et al. Folate and DNA methylation: A review of molecular mechanisms and the evidence for folate’s role. Adv Nutr. 2012, 3(1): 21-38.
[53]
PJ Stover. One-carbon metabolism-genome interactions folate- associated pathologies. J Nutr. 2009, 139(12): 2402-2405.
[54]
SG Ratti, EO Alvarez. The altered behavioural responses displayed by litter rats after chronic administration of non-toxic concentrations of ZnTe to parent rats are reversed by simultaneous folic acid treatment. Am J Neuroprotec Neuroregen. 2015, 7(1): 56-64.
[55]
SG Ratti, EO Alvarez. Selenium treatment modifies the epigenetic behavioural changes induced by chronic non-toxic administration of ZnTe to prepuberal rats. Am J Neuroprotec Neuroregen. 2016, 8(1): 66-74.
Journal of Neurorestoratology
Pages 37-46
Cite this article:
Ratti SG, Alvarez EO. Differential effects of zinc and tellurium on epigenetic changes of coping behaviour in maturing rats. Journal of Neurorestoratology, 2019, 7(1): 37-46. https://doi.org/10.26599/JNR.2019.9040001

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Received: 24 August 2018
Revised: 25 November 2018
Accepted: 14 January 2019
Published: 22 March 2019
© The authors 2019

This article is published with open access at http://jnr.tsinghuajournals.com

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