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Clinical neurorestorative therapies recently made great progress for patients with spinal cord injury (SCI). This paper systemically reviews historical perspectives, recent advancements and achievements in SCI through key neurorestorative strategies. In this study, a search was performed in the PubMed, Scopus, and Scholar Google search engines using the keywords “neurorestorative strategies”, “spinal cord injury”, “cell therapy”, “neuromodulation”, and “nerve bridges”. Clinical studies published in the English language were included. It is paramount for academic community involved in this field to take the initiative of a multicenter randomized, double-blind, and placebo-control clinical study with high level of evidence-based treatments for most SCI neurorestorative strategies in patient management. It is of utmost need to establish standard therapeutic methods for patients with SCI as early as possible.


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Review of clinical neurorestorative strategies for spinal cord injury: Exploring history and latest progresses

Show Author's information Hongyun Huang1,2Hari Shanker Sharma3Lin Chen4Ali Otom5Ziad M. Al Zoubi6Hooshang Saberi7Dafin F. Muresanu8Xijing He9
Institute of Neurorestoratology, Third Medical Center of PLA General Hospital, Beijing, China
Hongtianji Neuroscience Academy, Lingxiu building, Beijing, China
Intensive Experimental CNS Injury and Repair, University Hospital, UppsalaUniversity, Uppsala, Sweden
Department of Neurorestoratology, Tsinghua University Yuquan Hospital, Beijing, China
Royal Specialty Center for Spine and Musculoskeletal Disorders Amman, Jordan
Jordan Ortho and Spinal Centre, Al-Saif Medical Center, Amman, Jordan
Department of Neurosurgery, Brain and Spinal cord Injury Research center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
Department of Neurosciences “Iuliu Hatieganu,” University of Medicine and Pharmacy, Cluj-Napoca, Romania
Department of Orthopaedics, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

Abstract

Clinical neurorestorative therapies recently made great progress for patients with spinal cord injury (SCI). This paper systemically reviews historical perspectives, recent advancements and achievements in SCI through key neurorestorative strategies. In this study, a search was performed in the PubMed, Scopus, and Scholar Google search engines using the keywords “neurorestorative strategies”, “spinal cord injury”, “cell therapy”, “neuromodulation”, and “nerve bridges”. Clinical studies published in the English language were included. It is paramount for academic community involved in this field to take the initiative of a multicenter randomized, double-blind, and placebo-control clinical study with high level of evidence-based treatments for most SCI neurorestorative strategies in patient management. It is of utmost need to establish standard therapeutic methods for patients with SCI as early as possible.

Keywords:

neurorestorative strategies, spinal cord injury, cell therapy, neuromodulation, nerve bridges
Received: 01 December 2018 Accepted: 17 December 2018 Published: 30 December 2018 Issue date: December 2018
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Publication history

Received: 01 December 2018
Accepted: 17 December 2018
Published: 30 December 2018
Issue date: December 2018

Copyright

© The author(s) 2018

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© The authors 2018. This article is published with open access at http://jnr.tsinghuajournals.com

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